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• W2027520391 abstract "Accurate mitotic chromosome segregation depends on the formation of a microtubule-based bipolar spindle apparatus. We report that the cohesin subunit structural maintenance of chromosomes subunit 1 (SMC1) is recruited to microtubule-bound RNA export factor 1 (Rae1) at the mitotic spindle pole. We locate the Rae1-binding site to a 21-residue-long region, SMC1 947-967 and provide several lines of evidence that phosphorylation of Ser 957 and Ser 966 of SMC1 stimulates binding to Rae1. Imbalances in these assembly pathways caused formation of multipolar spindles. Our data suggest that cohesin's known bundling function for chromatids in mitotic and interphase cells extends to microtubules at the spindle pole." @default.
• W2027520391 created "2016-06-24" @default.
• W2027520391 creator A5029659594 @default.
• W2027520391 creator A5081060821 @default.
• W2027520391 date "2008-10-07" @default.
• W2027520391 modified "2023-09-25" @default.
• W2027520391 title "Cohesin subunit SMC1 associates with mitotic microtubules at the spindle pole" @default.
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• W2027520391 doi "https://doi.org/10.1073/pnas.0807660105" @default.
• W2027520391 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2557025" @default.
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