FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027548509> ?p ?o ?g. }

• W2027548509 endingPage "188" @default.
• W2027548509 startingPage "179" @default.
• W2027548509 abstract "The exact mechanisms of iron transport from endosomes to the target iron containing cellular proteins are currently unknown. To investigate this problem, we used the gradient gel electrophoresis and the sensitive detection of 59Fe by autoradiography to detect separate cellular iron compounds and their iron kinetics. Cells of human leukemic line K562 were labeled with [59Fe]transferrin for 30–600 s and cellular iron compounds in cell lysates were analyzed by native electrophoretic separation followed by 59Fe autoradiography. Starting with the first 30 s of iron uptake, iron was detectable in a large membrane bound protein complex (Band I) and in ferritin. Significant amounts of iron were also found in labile iron compound(s) with the molecular weight larger than 5000 as judged by ultrafiltration. Iron kinetics in these compartments was studied. Band I was the only compound with the kinetic properties of an intermediate. Transferrin, transferrin receptor and additional proteins of the approximate molecular weights of 130 000, 66 000 and 49 000 were found to be present in Band I. The labile iron compounds and ferritin behaved kinetically as end products. No evidence for low molecular weight transport intermediates was found. These results suggest that intracellular iron transport is highly compartmentalized, that iron released from endosomal transferrin passes to its cellular targets in a direct contact with the endosomal membrane complex assigned as Band I. The nature of the labile iron pool and its susceptibility to iron chelation is discussed." @default.
• W2027548509 created "2016-06-24" @default.
• W2027548509 creator A5056395546 @default.
• W2027548509 creator A5077703495 @default.
• W2027548509 date "1998-06-01" @default.
• W2027548509 modified "2023-10-18" @default.
• W2027548509 title "Iron transport in K562 cells: a kinetic study using native gel electrophoresis and 59Fe autoradiography" @default.
• W2027548509 cites W1480159764 @default.
• W2027548509 cites W1487654384 @default.
• W2027548509 cites W1497554006 @default.
• W2027548509 cites W1510505825 @default.
• W2027548509 cites W1525976258 @default.
• W2027548509 cites W1526693931 @default.
• W2027548509 cites W1527704924 @default.
• W2027548509 cites W1536598476 @default.
• W2027548509 cites W1544483469 @default.
• W2027548509 cites W1568628619 @default.
• W2027548509 cites W157133164 @default.
• W2027548509 cites W1590684642 @default.
• W2027548509 cites W1965780768 @default.
• W2027548509 cites W1982660671 @default.
• W2027548509 cites W2000156667 @default.
• W2027548509 cites W2005990206 @default.
• W2027548509 cites W2014496233 @default.
• W2027548509 cites W2018801266 @default.
• W2027548509 cites W2058409066 @default.
• W2027548509 cites W2060033458 @default.
• W2027548509 cites W2069006711 @default.
• W2027548509 cites W2073268419 @default.
• W2027548509 cites W2078319346 @default.
• W2027548509 cites W2079553299 @default.
• W2027548509 cites W2084797262 @default.
• W2027548509 cites W2086567353 @default.
• W2027548509 cites W2089770392 @default.
• W2027548509 cites W2094433137 @default.
• W2027548509 cites W2099819774 @default.
• W2027548509 cites W2102967627 @default.
• W2027548509 cites W2147487590 @default.
• W2027548509 cites W2150689174 @default.
• W2027548509 cites W77625167 @default.
• W2027548509 doi "https://doi.org/10.1016/s0167-4889(98)00039-1" @default.
• W2027548509 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9630620" @default.
• W2027548509 hasPublicationYear "1998" @default.
• W2027548509 type Work @default.
• W2027548509 sameAs 2027548509 @default.
• W2027548509 citedByCount "28" @default.
• W2027548509 countsByYear W20275485092013 @default.
• W2027548509 countsByYear W20275485092014 @default.
• W2027548509 countsByYear W20275485092015 @default.
• W2027548509 countsByYear W20275485092017 @default.
• W2027548509 countsByYear W20275485092018 @default.
• W2027548509 countsByYear W20275485092019 @default.
• W2027548509 countsByYear W20275485092020 @default.
• W2027548509 countsByYear W20275485092021 @default.
• W2027548509 crossrefType "journal-article" @default.
• W2027548509 hasAuthorship W2027548509A5056395546 @default.
• W2027548509 hasAuthorship W2027548509A5077703495 @default.
• W2027548509 hasBestOaLocation W20275485091 @default.
• W2027548509 hasConcept C102747710 @default.
• W2027548509 hasConcept C116084860 @default.
• W2027548509 hasConcept C121332964 @default.
• W2027548509 hasConcept C12554922 @default.
• W2027548509 hasConcept C148898269 @default.
• W2027548509 hasConcept C179104552 @default.
• W2027548509 hasConcept C185592680 @default.
• W2027548509 hasConcept C197404232 @default.
• W2027548509 hasConcept C22814914 @default.
• W2027548509 hasConcept C2778319317 @default.
• W2027548509 hasConcept C32264632 @default.
• W2027548509 hasConcept C40250595 @default.
• W2027548509 hasConcept C50817676 @default.
• W2027548509 hasConcept C55493867 @default.
• W2027548509 hasConcept C62520636 @default.
• W2027548509 hasConcept C79879829 @default.
• W2027548509 hasConcept C86803240 @default.
• W2027548509 hasConceptScore W2027548509C102747710 @default.
• W2027548509 hasConceptScore W2027548509C116084860 @default.
• W2027548509 hasConceptScore W2027548509C121332964 @default.
• W2027548509 hasConceptScore W2027548509C12554922 @default.
• W2027548509 hasConceptScore W2027548509C148898269 @default.
• W2027548509 hasConceptScore W2027548509C179104552 @default.
• W2027548509 hasConceptScore W2027548509C185592680 @default.
• W2027548509 hasConceptScore W2027548509C197404232 @default.
• W2027548509 hasConceptScore W2027548509C22814914 @default.
• W2027548509 hasConceptScore W2027548509C2778319317 @default.
• W2027548509 hasConceptScore W2027548509C32264632 @default.
• W2027548509 hasConceptScore W2027548509C40250595 @default.
• W2027548509 hasConceptScore W2027548509C50817676 @default.
• W2027548509 hasConceptScore W2027548509C55493867 @default.
• W2027548509 hasConceptScore W2027548509C62520636 @default.
• W2027548509 hasConceptScore W2027548509C79879829 @default.
• W2027548509 hasConceptScore W2027548509C86803240 @default.
• W2027548509 hasIssue "2" @default.
• W2027548509 hasLocation W20275485091 @default.
• W2027548509 hasLocation W20275485092 @default.
• W2027548509 hasOpenAccess W2027548509 @default.
• W2027548509 hasPrimaryLocation W20275485091 @default.
• W2027548509 hasRelatedWork W122543035 @default.

• next