FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027556502> ?p ?o ?g. }

• W2027556502 endingPage "337" @default.
• W2027556502 startingPage "311" @default.
• W2027556502 abstract "Protein–carbohydrate recognition plays a crucial role in a wide range of biological processes, required both for normal physiological functions and the onset of disease. Nature uses multivalency in carbohydrate–protein interactions as a strategy to overcome the low affinity found for singular binding of an individual saccharide epitope to a single carbohydrate recognition domain of a lectin. To mimic the complex multi-branched oligosaccharides found in glycoconjugates, which form the structural basis of multivalent carbohydrate–protein interactions, so-called glycoclusters and glycodendrimers have been designed to serve as high-affinity ligands of the respective receptor proteins. To allow a rational design of glycodendrimer-type molecules with regard to the receptor structures involved in carbohydrate recognition, a deeper knowledge of the dynamics of such molecules is desirable. Most glycodendrimers have to be considered highly flexible molecules with their conformational preferences most difficult to elucidate by experimental methods. Longtime molecular dynamics (MD) simulations with inclusion of explicit solvent molecules are suited to explore the conformational space accessible to glycodendrimers. Here, a detailed geometric and conformational analysis of 15 glycodendrimers and glycoclusters has been accomplished, which differ with regard to their core moieties, spacer characteristics and the type of terminal carbohydrate units. It is shown that the accessible conformational space depends strongly on the structural features of the core and spacer moieties and even on the type of terminating sugars. The obtained knowledge about possible spatial distributions of the sugar epitopes exposed on the investigated hyperbranched neoglycoconjugates is detailed for all examples and forms important information for the interpretation and prediction of affinity data, which can be deduced from biological testing of these multivalent neoglycoconjugates." @default.
• W2027556502 created "2016-06-24" @default.
• W2027556502 creator A5013580762 @default.
• W2027556502 creator A5041393374 @default.
• W2027556502 creator A5090674574 @default.
• W2027556502 date "2002-05-01" @default.
• W2027556502 modified "2023-10-16" @default.
• W2027556502 title "Molecular dynamics simulations of glycoclusters and glycodendrimers" @default.
• W2027556502 cites W1519383911 @default.
• W2027556502 cites W1691646448 @default.
• W2027556502 cites W1976167432 @default.
• W2027556502 cites W1976218923 @default.
• W2027556502 cites W1979438209 @default.
• W2027556502 cites W1979702180 @default.
• W2027556502 cites W1984076871 @default.
• W2027556502 cites W1985726900 @default.
• W2027556502 cites W1987409617 @default.
• W2027556502 cites W1989526854 @default.
• W2027556502 cites W1992034958 @default.
• W2027556502 cites W1992886596 @default.
• W2027556502 cites W1992888087 @default.
• W2027556502 cites W1995673129 @default.
• W2027556502 cites W1996900288 @default.
• W2027556502 cites W1999421045 @default.
• W2027556502 cites W2002749561 @default.
• W2027556502 cites W2002772847 @default.
• W2027556502 cites W2006010758 @default.
• W2027556502 cites W2016309934 @default.
• W2027556502 cites W2016420043 @default.
• W2027556502 cites W2020152760 @default.
• W2027556502 cites W2020811658 @default.
• W2027556502 cites W2020853062 @default.
• W2027556502 cites W2021206609 @default.
• W2027556502 cites W2021989115 @default.
• W2027556502 cites W2023945970 @default.
• W2027556502 cites W2026258231 @default.
• W2027556502 cites W2028062152 @default.
• W2027556502 cites W2037149817 @default.
• W2027556502 cites W2039888163 @default.
• W2027556502 cites W2040873935 @default.
• W2027556502 cites W2049653972 @default.
• W2027556502 cites W2054089869 @default.
• W2027556502 cites W2055471472 @default.
• W2027556502 cites W2055800251 @default.
• W2027556502 cites W2057074707 @default.
• W2027556502 cites W2058989696 @default.
• W2027556502 cites W2059375062 @default.
• W2027556502 cites W2060130346 @default.
• W2027556502 cites W2070892071 @default.
• W2027556502 cites W2070930244 @default.
• W2027556502 cites W2071524503 @default.
• W2027556502 cites W2074805315 @default.
• W2027556502 cites W2077946227 @default.
• W2027556502 cites W2085480844 @default.
• W2027556502 cites W2085635195 @default.
• W2027556502 cites W2085677500 @default.
• W2027556502 cites W2088065757 @default.
• W2027556502 cites W2093858965 @default.
• W2027556502 cites W2100063754 @default.
• W2027556502 cites W2100630873 @default.
• W2027556502 cites W2106038218 @default.
• W2027556502 cites W2109368310 @default.
• W2027556502 cites W2111629830 @default.
• W2027556502 cites W2125782486 @default.
• W2027556502 cites W2126818937 @default.
• W2027556502 cites W2129232972 @default.
• W2027556502 cites W2145061993 @default.
• W2027556502 cites W2146786384 @default.
• W2027556502 cites W2149230719 @default.
• W2027556502 cites W2168206768 @default.
• W2027556502 cites W2171330710 @default.
• W2027556502 cites W2289487130 @default.
• W2027556502 cites W350348423 @default.
• W2027556502 cites W4211067069 @default.
• W2027556502 cites W4250677743 @default.
• W2027556502 cites W4251775387 @default.
• W2027556502 cites W4323285037 @default.
• W2027556502 cites W85376228 @default.
• W2027556502 doi "https://doi.org/10.1016/s1389-0352(01)00072-1" @default.
• W2027556502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12071231" @default.
• W2027556502 hasPublicationYear "2002" @default.
• W2027556502 type Work @default.
• W2027556502 sameAs 2027556502 @default.
• W2027556502 citedByCount "26" @default.
• W2027556502 countsByYear W20275565022012 @default.
• W2027556502 countsByYear W20275565022013 @default.
• W2027556502 countsByYear W20275565022015 @default.
• W2027556502 countsByYear W20275565022016 @default.
• W2027556502 countsByYear W20275565022018 @default.
• W2027556502 countsByYear W20275565022019 @default.
• W2027556502 countsByYear W20275565022020 @default.
• W2027556502 crossrefType "journal-article" @default.
• W2027556502 hasAuthorship W2027556502A5013580762 @default.
• W2027556502 hasAuthorship W2027556502A5041393374 @default.
• W2027556502 hasAuthorship W2027556502A5090674574 @default.
• W2027556502 hasConcept C119599485 @default.
• W2027556502 hasConcept C127413603 @default.
• W2027556502 hasConcept C13426554 @default.

• next