Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027557353> ?p ?o ?g. }
- W2027557353 endingPage "448" @default.
- W2027557353 startingPage "436" @default.
- W2027557353 abstract "Unrestrained cell division in cancer cells is dependent upon mitosis and its related processes. Therefore, a proven effective strategy in cancer treatment has been to interfere with the function of the mitotic spindle. Despite the success of these anti-mitotic agents, tubulin itself remains the only spindle-associated protein targeted by clinically approved agents. However, in recent years major advances have been achieved in targeting proteins that associate with tubulin and the mitotic spindle. Mitotic kinases such as the Aurora and Polo families are receiving significant attention due to their vital roles in assuring proper centrosome separation and chromosome segregation. Indeed, potent and selective inhibitors of these kinases have entered clinical trials. Similarly, the kinesins, particularly kinesin spindle protein (KSP), have emerged as potential therapeutic targets and inhibitors of KSP are currently under evaluation in the clinic. Although inhibitors have not been reported, mitotic checkpoint kinases (Mad2) and separase are additional potential targets for therapeutic intervention. Continued investigation of mechanisms regulating mitotic events will likely reveal additional proteins and pathways that could be potentially targeted and thereby provide more effective therapeutic options for cancer patients." @default.
- W2027557353 created "2016-06-24" @default.
- W2027557353 creator A5055924314 @default.
- W2027557353 creator A5080900202 @default.
- W2027557353 creator A5085626001 @default.
- W2027557353 date "2006-08-01" @default.
- W2027557353 modified "2023-10-16" @default.
- W2027557353 title "Tubulin-Associated Drug Targets: Aurora Kinases, Polo-like Kinases, and Others" @default.
- W2027557353 cites W114219100 @default.
- W2027557353 cites W1516624356 @default.
- W2027557353 cites W1537737236 @default.
- W2027557353 cites W1544851750 @default.
- W2027557353 cites W1657157395 @default.
- W2027557353 cites W1823624119 @default.
- W2027557353 cites W1864382350 @default.
- W2027557353 cites W1958294525 @default.
- W2027557353 cites W1964212058 @default.
- W2027557353 cites W1967886589 @default.
- W2027557353 cites W1971901845 @default.
- W2027557353 cites W1972161591 @default.
- W2027557353 cites W1972644607 @default.
- W2027557353 cites W1972910961 @default.
- W2027557353 cites W1975957264 @default.
- W2027557353 cites W1976023782 @default.
- W2027557353 cites W1977409409 @default.
- W2027557353 cites W1979773817 @default.
- W2027557353 cites W1980577287 @default.
- W2027557353 cites W1982304115 @default.
- W2027557353 cites W1985499212 @default.
- W2027557353 cites W1987353686 @default.
- W2027557353 cites W1988678729 @default.
- W2027557353 cites W1989394815 @default.
- W2027557353 cites W1990317973 @default.
- W2027557353 cites W1998406437 @default.
- W2027557353 cites W2004828162 @default.
- W2027557353 cites W2004981153 @default.
- W2027557353 cites W2007767755 @default.
- W2027557353 cites W2008609502 @default.
- W2027557353 cites W2013720953 @default.
- W2027557353 cites W2014089858 @default.
- W2027557353 cites W2017338430 @default.
- W2027557353 cites W2021020196 @default.
- W2027557353 cites W2021246859 @default.
- W2027557353 cites W2027042262 @default.
- W2027557353 cites W2027516869 @default.
- W2027557353 cites W2027532431 @default.
- W2027557353 cites W2029178312 @default.
- W2027557353 cites W2031949048 @default.
- W2027557353 cites W2033923680 @default.
- W2027557353 cites W2038951216 @default.
- W2027557353 cites W2040120706 @default.
- W2027557353 cites W2040235495 @default.
- W2027557353 cites W2046089519 @default.
- W2027557353 cites W2050537958 @default.
- W2027557353 cites W2051163818 @default.
- W2027557353 cites W2051603299 @default.
- W2027557353 cites W2055342169 @default.
- W2027557353 cites W2058565204 @default.
- W2027557353 cites W2059676290 @default.
- W2027557353 cites W2060619702 @default.
- W2027557353 cites W2063619106 @default.
- W2027557353 cites W2064337685 @default.
- W2027557353 cites W2064469550 @default.
- W2027557353 cites W2068384749 @default.
- W2027557353 cites W2069643337 @default.
- W2027557353 cites W2069910776 @default.
- W2027557353 cites W2070239961 @default.
- W2027557353 cites W2071156666 @default.
- W2027557353 cites W2071450690 @default.
- W2027557353 cites W2076306878 @default.
- W2027557353 cites W2077007774 @default.
- W2027557353 cites W2078358000 @default.
- W2027557353 cites W2080149096 @default.
- W2027557353 cites W2080308138 @default.
- W2027557353 cites W2082087067 @default.
- W2027557353 cites W2084314276 @default.
- W2027557353 cites W2088309079 @default.
- W2027557353 cites W2091312754 @default.
- W2027557353 cites W2092307522 @default.
- W2027557353 cites W2092401565 @default.
- W2027557353 cites W2094718046 @default.
- W2027557353 cites W2095461683 @default.
- W2027557353 cites W2095486134 @default.
- W2027557353 cites W2100813299 @default.
- W2027557353 cites W2101679514 @default.
- W2027557353 cites W2102317602 @default.
- W2027557353 cites W2103835700 @default.
- W2027557353 cites W2104643398 @default.
- W2027557353 cites W2106285650 @default.
- W2027557353 cites W2106942695 @default.
- W2027557353 cites W2108231260 @default.
- W2027557353 cites W2109903344 @default.
- W2027557353 cites W2109935462 @default.
- W2027557353 cites W2111295861 @default.
- W2027557353 cites W2114220172 @default.
- W2027557353 cites W2120863112 @default.
- W2027557353 cites W2128553601 @default.
- W2027557353 cites W2130478624 @default.