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• W2027559237 abstract "A series of novel biphenyl piperazines was discovered as highly potent muscarinic acetylcholine receptor antagonists via high throughput screening and subsequent optimization. Compound 5c with respective 500- and 20-fold subtype selectivity for M3 over M2 and M1 exhibited excellent inhibitory activity and long duration of action in a bronchoconstriction in vivo model in mice via intranasal administration. The novel inhaled mAChR antagonists are potentially useful therapeutic agents for the treatment of chronic obstructive pulmonary disease." @default.
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• W2027559237 date "2008-09-18" @default.
• W2027559237 modified "2023-10-03" @default.
• W2027559237 title "Discovery of Biphenyl Piperazines as Novel and Long Acting Muscarinic Acetylcholine Receptor Antagonists" @default.
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• W2027559237 doi "https://doi.org/10.1021/jm800935u" @default.
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