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• W2027561111 abstract "The compound m-chlorophenylpiperazine (mCPP), which is known to trigger migraine-like head pain in some subjects, was evaluated for its ability to induce dural plasma protein extravasation (PPE) in guinea pigs. Intravenous mCPP dose-dependently increased PPE. This effect was inhibited by non-selective 5-HT 2 receptor antagonists (methysergide, LY53857, LY215840), by a peripherally restricted 5-HT 2 receptor antagonist (xylamidine) and by a 5-HT 2B selective receptor antagonist (LY202146). These data suggests that peripheral 5-HT 2B receptors mediate mCPP-induced PPE. The nitric oxide synthase inhibitor L-NAME and 5-HT 1 agonist sumatriptan also blocked mCPP-induced PPE, suggesting a role for nitric oxide (NO) and the trigeminal system, respectively. NO release has been linked to activation of the 5-HT 2B receptor on the vascular endothelium. However, LY202146 did not block PPE induced by electrical stimulation of the trigeminal ganglion. These data are consistent with activation of peripheral 5-HT 2B receptors initiating PPE and the theory that selective 5-HT 2B antagonists might be effective prophylactic therapies for migraine." @default.
• W2027561111 created "2016-06-24" @default.
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• W2027561111 date "2003-03-01" @default.
• W2027561111 modified "2023-09-27" @default.
• W2027561111 title "Neurogenic Dural Protein Extravasation Induced by Meta-Chlorophenylpiperazine (Mcpp) Involves Nitric Oxide and 5-HT_2B Receptor Activation" @default.
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• W2027561111 doi "https://doi.org/10.1046/j.1468-2982.2003.00464.x" @default.
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