FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027569065> ?p ?o ?g. }

• W2027569065 endingPage "282" @default.
• W2027569065 startingPage "277" @default.
• W2027569065 abstract "Kinin B1 receptors on rabbit aorta smooth muscle cells in culture were investigated. [3H]Des-Arg10-kallidin labeled a single site in cells at early passage with an equilibrium dissociation constant of 258 pM and a maximal binding density of approximately 680 sites/cell. Treatment of the same cells for 18 h with epidermal growth factor increased the binding density over 6-fold without affecting the ligand's affinity. At latter passages, the density of binding sites was found to increase and the growth factor had a much less pronounced effect. The rank order of potencies for agonist inhibition of binding (des-Arg10-kallidin > des-Arg9-BK = kallidin > bradykinin) was consistent with the specific labeling of a B1 receptor. Also, [3H]des-Arg10-kallidin binding was potently inhibited by the B1 receptor antagonist des-Arg9[Leu8]bradykinin but not by the B2 receptor antagonist Hoe 140. The agonists were found to stimulate phosphoinositide hydrolysis in the smooth muscle cells with an order of potencies that reflected their binding assay activities. Des-Arg9[Leu8] BK blocked the des-Arg10-kallidin response with a potency consistent with its known B1 receptor activity while Hoe 140 was inactive. These results demonstrate the presence of inducible B1 receptors on rabbit aorta smooth muscle cells in culture that couple to phospholipase C activation. These cells should be useful in future studies of the mechanisms and factors involved in the regulation of expression of the B1 receptor." @default.
• W2027569065 created "2016-06-24" @default.
• W2027569065 creator A5000609624 @default.
• W2027569065 creator A5017397064 @default.
• W2027569065 creator A5051118162 @default.
• W2027569065 creator A5073709377 @default.
• W2027569065 date "1994-02-01" @default.
• W2027569065 modified "2023-10-18" @default.
• W2027569065 title "Bradykinin B1 receptors in rabbit aorta smooth muscle cells in culture" @default.
• W2027569065 cites W1535884808 @default.
• W2027569065 cites W159198934 @default.
• W2027569065 cites W1889236699 @default.
• W2027569065 cites W1968222598 @default.
• W2027569065 cites W1971501265 @default.
• W2027569065 cites W1979316500 @default.
• W2027569065 cites W1988659390 @default.
• W2027569065 cites W1990045434 @default.
• W2027569065 cites W1991983815 @default.
• W2027569065 cites W1999193590 @default.
• W2027569065 cites W2000975493 @default.
• W2027569065 cites W2010464930 @default.
• W2027569065 cites W2035363849 @default.
• W2027569065 cites W2046029794 @default.
• W2027569065 cites W2050517158 @default.
• W2027569065 cites W2054039543 @default.
• W2027569065 cites W2059596663 @default.
• W2027569065 cites W2074631079 @default.
• W2027569065 cites W2080913361 @default.
• W2027569065 cites W2094445867 @default.
• W2027569065 cites W2105429058 @default.
• W2027569065 doi "https://doi.org/10.1016/0922-4106(94)90137-6" @default.
• W2027569065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8174610" @default.
• W2027569065 hasPublicationYear "1994" @default.
• W2027569065 type Work @default.
• W2027569065 sameAs 2027569065 @default.
• W2027569065 citedByCount "70" @default.
• W2027569065 countsByYear W20275690652012 @default.
• W2027569065 countsByYear W20275690652014 @default.
• W2027569065 countsByYear W20275690652015 @default.
• W2027569065 countsByYear W20275690652016 @default.
• W2027569065 crossrefType "journal-article" @default.
• W2027569065 hasAuthorship W2027569065A5000609624 @default.
• W2027569065 hasAuthorship W2027569065A5017397064 @default.
• W2027569065 hasAuthorship W2027569065A5051118162 @default.
• W2027569065 hasAuthorship W2027569065A5073709377 @default.
• W2027569065 hasConcept C126322002 @default.
• W2027569065 hasConcept C134018914 @default.
• W2027569065 hasConcept C153939273 @default.
• W2027569065 hasConcept C170493617 @default.
• W2027569065 hasConcept C185592680 @default.
• W2027569065 hasConcept C2776246183 @default.
• W2027569065 hasConcept C2776885963 @default.
• W2027569065 hasConcept C2777427919 @default.
• W2027569065 hasConcept C2778122271 @default.
• W2027569065 hasConcept C2778618036 @default.
• W2027569065 hasConcept C2778938600 @default.
• W2027569065 hasConcept C2779395532 @default.
• W2027569065 hasConcept C2779591629 @default.
• W2027569065 hasConcept C2779730486 @default.
• W2027569065 hasConcept C2992686903 @default.
• W2027569065 hasConcept C55493867 @default.
• W2027569065 hasConcept C71924100 @default.
• W2027569065 hasConcept C86803240 @default.
• W2027569065 hasConcept C86811712 @default.
• W2027569065 hasConcept C95444343 @default.
• W2027569065 hasConceptScore W2027569065C126322002 @default.
• W2027569065 hasConceptScore W2027569065C134018914 @default.
• W2027569065 hasConceptScore W2027569065C153939273 @default.
• W2027569065 hasConceptScore W2027569065C170493617 @default.
• W2027569065 hasConceptScore W2027569065C185592680 @default.
• W2027569065 hasConceptScore W2027569065C2776246183 @default.
• W2027569065 hasConceptScore W2027569065C2776885963 @default.
• W2027569065 hasConceptScore W2027569065C2777427919 @default.
• W2027569065 hasConceptScore W2027569065C2778122271 @default.
• W2027569065 hasConceptScore W2027569065C2778618036 @default.
• W2027569065 hasConceptScore W2027569065C2778938600 @default.
• W2027569065 hasConceptScore W2027569065C2779395532 @default.
• W2027569065 hasConceptScore W2027569065C2779591629 @default.
• W2027569065 hasConceptScore W2027569065C2779730486 @default.
• W2027569065 hasConceptScore W2027569065C2992686903 @default.
• W2027569065 hasConceptScore W2027569065C55493867 @default.
• W2027569065 hasConceptScore W2027569065C71924100 @default.
• W2027569065 hasConceptScore W2027569065C86803240 @default.
• W2027569065 hasConceptScore W2027569065C86811712 @default.
• W2027569065 hasConceptScore W2027569065C95444343 @default.
• W2027569065 hasIssue "3" @default.
• W2027569065 hasLocation W20275690651 @default.
• W2027569065 hasLocation W20275690652 @default.
• W2027569065 hasOpenAccess W2027569065 @default.
• W2027569065 hasPrimaryLocation W20275690651 @default.
• W2027569065 hasRelatedWork W1565137730 @default.
• W2027569065 hasRelatedWork W2008107223 @default.
• W2027569065 hasRelatedWork W2009711718 @default.
• W2027569065 hasRelatedWork W2015489274 @default.
• W2027569065 hasRelatedWork W2031892072 @default.
• W2027569065 hasRelatedWork W2043077654 @default.
• W2027569065 hasRelatedWork W2081358424 @default.
• W2027569065 hasRelatedWork W2973655474 @default.

• next