FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027587310> ?p ?o ?g. }

• W2027587310 abstract "Leukocytes from individuals with warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome, a rare immunodeficiency, and bearing a wild-type CXCR4 ORF (WHIMWT) display impaired CXCR4 internalization and desensitization upon exposure to CXCL12. The resulting enhanced CXCR4-dependent responses, including chemotaxis, probably impair leukocyte trafficking and account for the immunohematologic clinical manifestations of WHIM syndrome. We provided here evidence that GPCR kinase-3 (GRK3) specifically regulates CXCL12-promoted internalization and desensitization of CXCR4. GRK3-silenced control cells displayed altered CXCR4 attenuation and enhanced chemotaxis, as did WHIMWT cells. These findings identified GRK3 as a negative regulator of CXCL12-induced chemotaxis and as a candidate responsible for CXCR4 dysfunction in WHIMWT leukocytes. Consistent with this, we showed that GRK3 overexpression in both leukocytes and skin fibroblasts from 2 unrelated WHIMWT patients restored CXCL12-induced internalization and desensitization of CXCR4 and normalized chemotaxis. Moreover, we found in cells derived from one patient a profound and selective decrease in GRK3 products that probably resulted from defective mRNA synthesis. Taken together, these results have revealed a pivotal role for GRK3 in regulating CXCR4 attenuation and have provided a mechanistic link between the GRK3 pathway and the CXCR4-related WHIMWT disorder." @default.
• W2027587310 created "2016-06-24" @default.
• W2027587310 creator A5002217794 @default.
• W2027587310 creator A5005937334 @default.
• W2027587310 creator A5017305689 @default.
• W2027587310 creator A5038428272 @default.
• W2027587310 creator A5040644322 @default.
• W2027587310 creator A5060157984 @default.
• W2027587310 creator A5067748416 @default.
• W2027587310 creator A5069813095 @default.
• W2027587310 creator A5088509972 @default.
• W2027587310 date "2008-02-01" @default.
• W2027587310 modified "2023-10-09" @default.
• W2027587310 title "Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling" @default.
• W2027587310 cites W1551542801 @default.
• W2027587310 cites W1652605626 @default.
• W2027587310 cites W1853587966 @default.
• W2027587310 cites W1862601554 @default.
• W2027587310 cites W1917182292 @default.
• W2027587310 cites W1968924261 @default.
• W2027587310 cites W1979103781 @default.
• W2027587310 cites W1981149366 @default.
• W2027587310 cites W1981267775 @default.
• W2027587310 cites W1989707466 @default.
• W2027587310 cites W1994161105 @default.
• W2027587310 cites W1999983353 @default.
• W2027587310 cites W2000441944 @default.
• W2027587310 cites W2003476666 @default.
• W2027587310 cites W2006268283 @default.
• W2027587310 cites W2009537829 @default.
• W2027587310 cites W2009694933 @default.
• W2027587310 cites W2013581305 @default.
• W2027587310 cites W2039146726 @default.
• W2027587310 cites W2046844598 @default.
• W2027587310 cites W2049308539 @default.
• W2027587310 cites W2053789319 @default.
• W2027587310 cites W2058334083 @default.
• W2027587310 cites W2062655974 @default.
• W2027587310 cites W2063556228 @default.
• W2027587310 cites W2066627186 @default.
• W2027587310 cites W2079317830 @default.
• W2027587310 cites W2094619489 @default.
• W2027587310 cites W2102300714 @default.
• W2027587310 cites W2118579624 @default.
• W2027587310 cites W2119398013 @default.
• W2027587310 cites W2132390808 @default.
• W2027587310 cites W2135319033 @default.
• W2027587310 cites W2137154584 @default.
• W2027587310 cites W2139919527 @default.
• W2027587310 cites W2141030777 @default.
• W2027587310 cites W2141528503 @default.
• W2027587310 cites W2147229999 @default.
• W2027587310 cites W2150769574 @default.
• W2027587310 cites W2153091412 @default.
• W2027587310 cites W2154229564 @default.
• W2027587310 cites W2158049812 @default.
• W2027587310 cites W2158294445 @default.
• W2027587310 cites W2165244186 @default.
• W2027587310 cites W2167070743 @default.
• W2027587310 cites W2169101659 @default.
• W2027587310 cites W2186222074 @default.
• W2027587310 cites W2215655815 @default.
• W2027587310 doi "https://doi.org/10.1172/jci33187" @default.
• W2027587310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2242619" @default.
• W2027587310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18274673" @default.
• W2027587310 hasPublicationYear "2008" @default.
• W2027587310 type Work @default.
• W2027587310 sameAs 2027587310 @default.
• W2027587310 citedByCount "57" @default.
• W2027587310 countsByYear W20275873102012 @default.
• W2027587310 countsByYear W20275873102013 @default.
• W2027587310 countsByYear W20275873102014 @default.
• W2027587310 countsByYear W20275873102015 @default.
• W2027587310 countsByYear W20275873102016 @default.
• W2027587310 countsByYear W20275873102017 @default.
• W2027587310 countsByYear W20275873102018 @default.
• W2027587310 countsByYear W20275873102019 @default.
• W2027587310 countsByYear W20275873102020 @default.
• W2027587310 countsByYear W20275873102021 @default.
• W2027587310 countsByYear W20275873102022 @default.
• W2027587310 countsByYear W20275873102023 @default.
• W2027587310 crossrefType "journal-article" @default.
• W2027587310 hasAuthorship W2027587310A5002217794 @default.
• W2027587310 hasAuthorship W2027587310A5005937334 @default.
• W2027587310 hasAuthorship W2027587310A5017305689 @default.
• W2027587310 hasAuthorship W2027587310A5038428272 @default.
• W2027587310 hasAuthorship W2027587310A5040644322 @default.
• W2027587310 hasAuthorship W2027587310A5060157984 @default.
• W2027587310 hasAuthorship W2027587310A5067748416 @default.
• W2027587310 hasAuthorship W2027587310A5069813095 @default.
• W2027587310 hasAuthorship W2027587310A5088509972 @default.
• W2027587310 hasBestOaLocation W20275873101 @default.
• W2027587310 hasConcept C126322002 @default.
• W2027587310 hasConcept C129470790 @default.
• W2027587310 hasConcept C13373296 @default.
• W2027587310 hasConcept C139770010 @default.
• W2027587310 hasConcept C170493617 @default.
• W2027587310 hasConcept C203014093 @default.
• W2027587310 hasConcept C2776914184 @default.
• W2027587310 hasConcept C2779779143 @default.

• next