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• W2027605433 endingPage "1946" @default.
• W2027605433 startingPage "1939" @default.
• W2027605433 abstract "Chagas’ disease is an important parasitic illness caused by the flagellated protozoan Trypanosoma cruzi. The disease affects nearly 17 million individuals in endemic areas of Latin America and the current chemotherapy is quite unsatisfactory based on nitroheterocyclic agents (nifurtimox and benznidazol). The need for new compounds with different modes of action is clear. Due to the broad-spectrum antimicrobial activity of the aromatic dicationic compounds, this study focused on the activity of four such diamidines (DB811, DB889, DB786, DB702) and a closely related diguanidine (DB711) against bloodstream trypomastigotes as well as intracellular amastigotes of T. cruzi in vitro. Additional studies were also conducted to access the toxicity of the compounds against mammalian cells in vitro. Our data show that the four diamidines compounds presented early and high anti-parasitic activity (IC50 in low-micromolecular range) exhibiting trypanocidal dose-dependent effects against both trypomastigote and amastigote forms of T. cruzi 2 h after drug treatment. Most of the diamidines compounds (except the DB702) exerted high anti-parasitic activity and low toxicity to the mammalian cells. Our results show the activity of reversed diamidines against T. cruzi and suggested that the compounds merit in vivo studies." @default.
• W2027605433 created "2016-06-24" @default.
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• W2027605433 date "2007-06-01" @default.
• W2027605433 modified "2023-09-23" @default.
• W2027605433 title "Activity of “reversed” diamidines against Trypanosoma cruzi “in vitro”" @default.
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• W2027605433 doi "https://doi.org/10.1016/j.bcp.2007.03.020" @default.
• W2027605433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17462605" @default.
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