FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027608806> ?p ?o ?g. }

• W2027608806 endingPage "216" @default.
• W2027608806 startingPage "209" @default.
• W2027608806 abstract "Selective application of metal chelators to homogenates of human Alzheimer's disease (AD) brain has led us to propose that the architecture of aggregated β-amyloid peptide, whether in the form of plaques or soluble oligomers, is determined at least in part by high-affinity binding of transition metals, especially copper and zinc. Of the two metals, copper is implicated in reactive oxygen species generating reactions, while zinc appears to be associated with conformational and antioxidant activity. We tested the copper chelators trientine, penicillamine, and bathophenanthroline for their ability to mobilize brain Aβ as measured against our benchmark compound bathocuproine (BC). All of these agents were effective in solubilizing brain Aβ, although BC was the most consistent across the range of AD brain tissue samples tested. Similarly, all of the copper chelators depleted copper in the high-speed supernatants. BC alone had no significant effect upon zinc levels in the soluble fraction. BC extraction of brain tissue from C100 transgenic mice (which express human Aβ but do not develop amyloid) revealed SDS-resistant dimers as Aβ was mobilized from the sedimentable to the soluble fraction. NMR analysis showed that, in addition to its copper chelating properties, BC interacts with Aβ to form a complex independent of the presence of copper. Such hybrid copper chelating and “chain breaking” properties may form the basis of a rational design for a therapy for Alzheimer's disease." @default.
• W2027608806 created "2016-06-24" @default.
• W2027608806 creator A5000808429 @default.
• W2027608806 creator A5005681347 @default.
• W2027608806 creator A5006373060 @default.
• W2027608806 creator A5033772486 @default.
• W2027608806 creator A5034130805 @default.
• W2027608806 creator A5038374630 @default.
• W2027608806 creator A5047385288 @default.
• W2027608806 creator A5050004777 @default.
• W2027608806 creator A5054461576 @default.
• W2027608806 creator A5064378943 @default.
• W2027608806 creator A5084089720 @default.
• W2027608806 date "2000-06-01" @default.
• W2027608806 modified "2023-10-18" @default.
• W2027608806 title "Chelation and Intercalation: Complementary Properties in a Compound for the Treatment of Alzheimer's Disease" @default.
• W2027608806 cites W157666778 @default.
• W2027608806 cites W1879184430 @default.
• W2027608806 cites W1971966571 @default.
• W2027608806 cites W1986091822 @default.
• W2027608806 cites W1993710449 @default.
• W2027608806 cites W1996579240 @default.
• W2027608806 cites W2017550829 @default.
• W2027608806 cites W2036620431 @default.
• W2027608806 cites W2056745213 @default.
• W2027608806 cites W2063236931 @default.
• W2027608806 cites W2069787626 @default.
• W2027608806 cites W2070045579 @default.
• W2027608806 cites W2071310220 @default.
• W2027608806 cites W2083500052 @default.
• W2027608806 cites W2083951306 @default.
• W2027608806 cites W2088151512 @default.
• W2027608806 cites W2091124986 @default.
• W2027608806 cites W2093700493 @default.
• W2027608806 cites W2100610042 @default.
• W2027608806 cites W2111658457 @default.
• W2027608806 cites W2131633241 @default.
• W2027608806 cites W2143643970 @default.
• W2027608806 cites W2146729934 @default.
• W2027608806 doi "https://doi.org/10.1006/jsbi.2000.4285" @default.
• W2027608806 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10940226" @default.
• W2027608806 hasPublicationYear "2000" @default.
• W2027608806 type Work @default.
• W2027608806 sameAs 2027608806 @default.
• W2027608806 citedByCount "77" @default.
• W2027608806 countsByYear W20276088062012 @default.
• W2027608806 countsByYear W20276088062013 @default.
• W2027608806 countsByYear W20276088062014 @default.
• W2027608806 countsByYear W20276088062015 @default.
• W2027608806 countsByYear W20276088062016 @default.
• W2027608806 countsByYear W20276088062017 @default.
• W2027608806 countsByYear W20276088062018 @default.
• W2027608806 countsByYear W20276088062019 @default.
• W2027608806 countsByYear W20276088062021 @default.
• W2027608806 countsByYear W20276088062022 @default.
• W2027608806 countsByYear W20276088062023 @default.
• W2027608806 crossrefType "journal-article" @default.
• W2027608806 hasAuthorship W2027608806A5000808429 @default.
• W2027608806 hasAuthorship W2027608806A5005681347 @default.
• W2027608806 hasAuthorship W2027608806A5006373060 @default.
• W2027608806 hasAuthorship W2027608806A5033772486 @default.
• W2027608806 hasAuthorship W2027608806A5034130805 @default.
• W2027608806 hasAuthorship W2027608806A5038374630 @default.
• W2027608806 hasAuthorship W2027608806A5047385288 @default.
• W2027608806 hasAuthorship W2027608806A5050004777 @default.
• W2027608806 hasAuthorship W2027608806A5054461576 @default.
• W2027608806 hasAuthorship W2027608806A5064378943 @default.
• W2027608806 hasAuthorship W2027608806A5084089720 @default.
• W2027608806 hasConcept C12554922 @default.
• W2027608806 hasConcept C178790620 @default.
• W2027608806 hasConcept C179104552 @default.
• W2027608806 hasConcept C185592680 @default.
• W2027608806 hasConcept C197404232 @default.
• W2027608806 hasConcept C2778004101 @default.
• W2027608806 hasConcept C2779281246 @default.
• W2027608806 hasConcept C2779348387 @default.
• W2027608806 hasConcept C535196362 @default.
• W2027608806 hasConcept C544778455 @default.
• W2027608806 hasConcept C55493867 @default.
• W2027608806 hasConcept C71240020 @default.
• W2027608806 hasConcept C86803240 @default.
• W2027608806 hasConceptScore W2027608806C12554922 @default.
• W2027608806 hasConceptScore W2027608806C178790620 @default.
• W2027608806 hasConceptScore W2027608806C179104552 @default.
• W2027608806 hasConceptScore W2027608806C185592680 @default.
• W2027608806 hasConceptScore W2027608806C197404232 @default.
• W2027608806 hasConceptScore W2027608806C2778004101 @default.
• W2027608806 hasConceptScore W2027608806C2779281246 @default.
• W2027608806 hasConceptScore W2027608806C2779348387 @default.
• W2027608806 hasConceptScore W2027608806C535196362 @default.
• W2027608806 hasConceptScore W2027608806C544778455 @default.
• W2027608806 hasConceptScore W2027608806C55493867 @default.
• W2027608806 hasConceptScore W2027608806C71240020 @default.
• W2027608806 hasConceptScore W2027608806C86803240 @default.
• W2027608806 hasIssue "2-3" @default.
• W2027608806 hasLocation W20276088061 @default.
• W2027608806 hasLocation W20276088062 @default.
• W2027608806 hasOpenAccess W2027608806 @default.

• next