Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027624313> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2027624313 endingPage "123" @default.
- W2027624313 startingPage "119" @default.
- W2027624313 abstract "The growth of the cultured human breast carcinoma cell line NUB 1 as well as that of other cultured malignant cells has been shown to be inhibited by addition of gamma-linolenic acid (GLA) to the culture medium. It has previously been suggested that these findings may be attributed to correction of a GLA deficiency in malignant cells, with supplementation of this fatty acid leading to increased prostaglandin (PG) production and consequent growth inhibition. To test this hypothesis the effect of 50 micrograms/ml concentrations of GLA and its sequential metabolite dihomo-gamma-linolenic acid (DGLA) and cell growth, morphology and prostaglandin (PGE and PGF) production by NUB 1 cells was investigated. GLA increased PGE and PGF production, inhibited cell growth and caused accumulation of lipid containing cytoplasmic granules. While treatment with DGLA increased PG production to a significantly greater extent than GLA administration it had no apparent effect on cell growth of morphology and did not inhibit cell growth. These findings suggest that some action other than the ability to increase PG production may be responsible for the inhibitory effects produced by GLA in malignant cells." @default.
- W2027624313 created "2016-06-24" @default.
- W2027624313 creator A5031195173 @default.
- W2027624313 creator A5042578537 @default.
- W2027624313 creator A5047480968 @default.
- W2027624313 creator A5070544441 @default.
- W2027624313 date "1989-02-01" @default.
- W2027624313 modified "2023-10-01" @default.
- W2027624313 title "The role of prostaglandins in the inhibition of cultured carcinoma cell growth produced by gamma-linolenic acid" @default.
- W2027624313 cites W1775749144 @default.
- W2027624313 cites W1970069185 @default.
- W2027624313 cites W1970345513 @default.
- W2027624313 cites W1975840582 @default.
- W2027624313 cites W1976720728 @default.
- W2027624313 cites W2011233116 @default.
- W2027624313 cites W2016336822 @default.
- W2027624313 cites W2026338350 @default.
- W2027624313 cites W2031141021 @default.
- W2027624313 cites W2039084196 @default.
- W2027624313 cites W2091163869 @default.
- W2027624313 doi "https://doi.org/10.1016/0952-3278(89)90175-0" @default.
- W2027624313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2541450" @default.
- W2027624313 hasPublicationYear "1989" @default.
- W2027624313 type Work @default.
- W2027624313 sameAs 2027624313 @default.
- W2027624313 citedByCount "11" @default.
- W2027624313 countsByYear W20276243132014 @default.
- W2027624313 countsByYear W20276243132015 @default.
- W2027624313 countsByYear W20276243132018 @default.
- W2027624313 countsByYear W20276243132020 @default.
- W2027624313 crossrefType "journal-article" @default.
- W2027624313 hasAuthorship W2027624313A5031195173 @default.
- W2027624313 hasAuthorship W2027624313A5042578537 @default.
- W2027624313 hasAuthorship W2027624313A5047480968 @default.
- W2027624313 hasAuthorship W2027624313A5070544441 @default.
- W2027624313 hasConcept C126322002 @default.
- W2027624313 hasConcept C134018914 @default.
- W2027624313 hasConcept C1491633281 @default.
- W2027624313 hasConcept C181199279 @default.
- W2027624313 hasConcept C19038510 @default.
- W2027624313 hasConcept C2776352991 @default.
- W2027624313 hasConcept C2777198256 @default.
- W2027624313 hasConcept C2777477808 @default.
- W2027624313 hasConcept C2778078955 @default.
- W2027624313 hasConcept C2779311130 @default.
- W2027624313 hasConcept C2779707156 @default.
- W2027624313 hasConcept C2780664492 @default.
- W2027624313 hasConcept C543025807 @default.
- W2027624313 hasConcept C54355233 @default.
- W2027624313 hasConcept C55493867 @default.
- W2027624313 hasConcept C62112901 @default.
- W2027624313 hasConcept C71924100 @default.
- W2027624313 hasConcept C81885089 @default.
- W2027624313 hasConcept C86803240 @default.
- W2027624313 hasConceptScore W2027624313C126322002 @default.
- W2027624313 hasConceptScore W2027624313C134018914 @default.
- W2027624313 hasConceptScore W2027624313C1491633281 @default.
- W2027624313 hasConceptScore W2027624313C181199279 @default.
- W2027624313 hasConceptScore W2027624313C19038510 @default.
- W2027624313 hasConceptScore W2027624313C2776352991 @default.
- W2027624313 hasConceptScore W2027624313C2777198256 @default.
- W2027624313 hasConceptScore W2027624313C2777477808 @default.
- W2027624313 hasConceptScore W2027624313C2778078955 @default.
- W2027624313 hasConceptScore W2027624313C2779311130 @default.
- W2027624313 hasConceptScore W2027624313C2779707156 @default.
- W2027624313 hasConceptScore W2027624313C2780664492 @default.
- W2027624313 hasConceptScore W2027624313C543025807 @default.
- W2027624313 hasConceptScore W2027624313C54355233 @default.
- W2027624313 hasConceptScore W2027624313C55493867 @default.
- W2027624313 hasConceptScore W2027624313C62112901 @default.
- W2027624313 hasConceptScore W2027624313C71924100 @default.
- W2027624313 hasConceptScore W2027624313C81885089 @default.
- W2027624313 hasConceptScore W2027624313C86803240 @default.
- W2027624313 hasIssue "2" @default.
- W2027624313 hasLocation W20276243131 @default.
- W2027624313 hasLocation W20276243132 @default.
- W2027624313 hasOpenAccess W2027624313 @default.
- W2027624313 hasPrimaryLocation W20276243131 @default.
- W2027624313 hasRelatedWork W118088385 @default.
- W2027624313 hasRelatedWork W2016034363 @default.
- W2027624313 hasRelatedWork W2027624313 @default.
- W2027624313 hasRelatedWork W2049319221 @default.
- W2027624313 hasRelatedWork W2053995479 @default.
- W2027624313 hasRelatedWork W2056100207 @default.
- W2027624313 hasRelatedWork W2060195701 @default.
- W2027624313 hasRelatedWork W2086410927 @default.
- W2027624313 hasRelatedWork W2094030766 @default.
- W2027624313 hasRelatedWork W2402918231 @default.
- W2027624313 hasVolume "35" @default.
- W2027624313 isParatext "false" @default.
- W2027624313 isRetracted "false" @default.
- W2027624313 magId "2027624313" @default.
- W2027624313 workType "article" @default.