FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027647961> ?p ?o ?g. }

• W2027647961 endingPage "752" @default.
• W2027647961 startingPage "745" @default.
• W2027647961 abstract "Adiponectin is an adipose-derived protein which has anti-inflammatory and anti-atherogenic properties in addition to insulin-sensitizing effects. To date, the role of adiponectin in the pathogenesis of diabetic nephropathy remains unclear. The aim of the present study was to explore the relationship between adiponectin and renal tubular injury in diabetic nephropathy. We determined serum and urinary adiponectin levels in type 2 diabetic patients with normoalbuminuria (n = 19), microalbuminuria (n = 18), and overt diabetic nephropathy (n = 16), and then analyzed the correlations between serum and urinary adiponectin, urinary N-acetylglucosaminidase (NAG) as a clinical marker of renal tubular injury, urinary monocyte chemoattractant protein-1 (MCP-1) as an inflammatory marker in renal tubulointerstitium, and clinical markers of renal disease. Notably, serum and urinary adiponectin levels were significantly increased in patients with overt diabetic nephropathy compared to those with normoalbuminuria and microalbuminuria. In univariate linear regression analysis, serum adiponectin levels were positively correlated with serum creatinine (r = 0.648, P<0.0001), urinary albumin (r = 0.583, P<0.0001), urinary NAG (r = 0.406, P<0.01), urinary MCP-1 (r = 0.514, P<0.0001), and urinary adiponectin (r = 0.691, P<0.0001) levels in all diabetic patients. Urinary adiponectin levels were also positively correlated with serum creatinine (r = 0.729, P<0.0001), urinary albumin (r = 0.799, P<0.0001), urinary NAG (r = 0.701, P<0.0001), and urinary MCP-1 (r = 0.801, P<0.0001) levels in all diabetic patients. Multiple linear regression analysis showed that serum creatinine and urinary adiponectin levels were independently associated with serum adiponectin levels (r2 = 0.522), and that serum creatinine, urinary NAG, urinary MCP-1, and serum adiponectin levels were independent determinants of urinary adiponectin levels (r2 = 0.851). These results collectively indicate that renal insufficiency and tubular injury possibly play a contributory role in increases in serum and urinary adiponectin levels in overt diabetic nephropathy. We presume that an increase in circulating adiponectin in overt diabetic nephropathy might be a physiological response to mitigate renal tubular injury and to prevent the further progression of diabetic nephropathy through its anti-inflammatory and anti-atherogenic effects." @default.
• W2027647961 created "2016-06-24" @default.
• W2027647961 creator A5006308493 @default.
• W2027647961 creator A5016507641 @default.
• W2027647961 creator A5023757160 @default.
• W2027647961 creator A5041218978 @default.
• W2027647961 creator A5043285114 @default.
• W2027647961 creator A5044499778 @default.
• W2027647961 creator A5055016294 @default.
• W2027647961 creator A5060279300 @default.
• W2027647961 creator A5061623209 @default.
• W2027647961 creator A5066952889 @default.
• W2027647961 date "2006-01-01" @default.
• W2027647961 modified "2023-10-15" @default.
• W2027647961 title "Possible Relationship between Adiponectin and Renal Tubular Injury in Diabetic Nephropathy" @default.
• W2027647961 cites W1524321743 @default.
• W2027647961 cites W1587875569 @default.
• W2027647961 cites W1974485274 @default.
• W2027647961 cites W1981261500 @default.
• W2027647961 cites W1982375410 @default.
• W2027647961 cites W1997037052 @default.
• W2027647961 cites W2001727439 @default.
• W2027647961 cites W2007098380 @default.
• W2027647961 cites W2021500058 @default.
• W2027647961 cites W2028404765 @default.
• W2027647961 cites W2060168906 @default.
• W2027647961 cites W2060986496 @default.
• W2027647961 cites W2080139689 @default.
• W2027647961 cites W2095726149 @default.
• W2027647961 cites W2097794068 @default.
• W2027647961 cites W2105617463 @default.
• W2027647961 cites W2108872143 @default.
• W2027647961 cites W2108931588 @default.
• W2027647961 cites W2138750223 @default.
• W2027647961 cites W2139801418 @default.
• W2027647961 cites W2142831736 @default.
• W2027647961 cites W2143437118 @default.
• W2027647961 cites W2144702900 @default.
• W2027647961 cites W2146438603 @default.
• W2027647961 cites W2153366902 @default.
• W2027647961 cites W2165391345 @default.
• W2027647961 cites W4235391466 @default.
• W2027647961 cites W4242152781 @default.
• W2027647961 doi "https://doi.org/10.1507/endocrj.k06-016" @default.
• W2027647961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16966829" @default.
• W2027647961 hasPublicationYear "2006" @default.
• W2027647961 type Work @default.
• W2027647961 sameAs 2027647961 @default.
• W2027647961 citedByCount "59" @default.
• W2027647961 countsByYear W20276479612012 @default.
• W2027647961 countsByYear W20276479612013 @default.
• W2027647961 countsByYear W20276479612014 @default.
• W2027647961 countsByYear W20276479612015 @default.
• W2027647961 countsByYear W20276479612016 @default.
• W2027647961 countsByYear W20276479612017 @default.
• W2027647961 countsByYear W20276479612018 @default.
• W2027647961 countsByYear W20276479612019 @default.
• W2027647961 countsByYear W20276479612020 @default.
• W2027647961 countsByYear W20276479612021 @default.
• W2027647961 countsByYear W20276479612022 @default.
• W2027647961 crossrefType "journal-article" @default.
• W2027647961 hasAuthorship W2027647961A5006308493 @default.
• W2027647961 hasAuthorship W2027647961A5016507641 @default.
• W2027647961 hasAuthorship W2027647961A5023757160 @default.
• W2027647961 hasAuthorship W2027647961A5041218978 @default.
• W2027647961 hasAuthorship W2027647961A5043285114 @default.
• W2027647961 hasAuthorship W2027647961A5044499778 @default.
• W2027647961 hasAuthorship W2027647961A5055016294 @default.
• W2027647961 hasAuthorship W2027647961A5060279300 @default.
• W2027647961 hasAuthorship W2027647961A5061623209 @default.
• W2027647961 hasAuthorship W2027647961A5066952889 @default.
• W2027647961 hasBestOaLocation W20276479611 @default.
• W2027647961 hasConcept C126322002 @default.
• W2027647961 hasConcept C134018914 @default.
• W2027647961 hasConcept C2776782570 @default.
• W2027647961 hasConcept C2777391703 @default.
• W2027647961 hasConcept C2779922275 @default.
• W2027647961 hasConcept C2780306776 @default.
• W2027647961 hasConcept C2781184683 @default.
• W2027647961 hasConcept C2781203188 @default.
• W2027647961 hasConcept C555293320 @default.
• W2027647961 hasConcept C71924100 @default.
• W2027647961 hasConcept C77411442 @default.
• W2027647961 hasConceptScore W2027647961C126322002 @default.
• W2027647961 hasConceptScore W2027647961C134018914 @default.
• W2027647961 hasConceptScore W2027647961C2776782570 @default.
• W2027647961 hasConceptScore W2027647961C2777391703 @default.
• W2027647961 hasConceptScore W2027647961C2779922275 @default.
• W2027647961 hasConceptScore W2027647961C2780306776 @default.
• W2027647961 hasConceptScore W2027647961C2781184683 @default.
• W2027647961 hasConceptScore W2027647961C2781203188 @default.
• W2027647961 hasConceptScore W2027647961C555293320 @default.
• W2027647961 hasConceptScore W2027647961C71924100 @default.
• W2027647961 hasConceptScore W2027647961C77411442 @default.
• W2027647961 hasIssue "6" @default.
• W2027647961 hasLocation W20276479611 @default.
• W2027647961 hasLocation W20276479612 @default.
• W2027647961 hasOpenAccess W2027647961 @default.

• next