FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027655401> ?p ?o ?g. }

• W2027655401 endingPage "326" @default.
• W2027655401 startingPage "320" @default.
• W2027655401 abstract "Abstract: The intercellular tight junctions (TJs) of endothelial cells represent the limiting structure for the permeability of the blood—brain barrier (BBB). Although the BBB has been recognized as being the interface between the bloodstream and the brain, little is known about its regulation. Zonulin and its prokaryotic analogue, zonula occludens toxin (Zot) elaborated by Vibrio cholerae, both modulate intercellular TJs by binding to a specific surface receptor with subsequent activation of an intracellular signaling pathway involving phospholipase C and protein kinase C activation and actin polymerization. Affinity column purification revealed that human brain plasma membrane preparations contain two Zot binding proteins of ∼55 and ∼45 kDa. Structural and kinetic studies, including saturation and competitive assays, identified the 55-kDa protein as tubulin, whereas the 45-kDa protein represents the zonulin/Zot receptor. Biochemical characterization provided evidence that this receptor is a glycoprotein containing multiple sialic acid residues. Comparison of the N-terminal sequence of the zonulin/Zot receptor with other protein sequences by BLAST analysis revealed a striking similarity with MRP-8, a 14-kDa member of the S-100 family of calcium binding proteins. The discovery and characterization of this receptor from human brain may significantly contribute to our knowledge on the pathophysiological regulation of the BBB." @default.
• W2027655401 created "2016-06-24" @default.
• W2027655401 creator A5005895756 @default.
• W2027655401 creator A5046930712 @default.
• W2027655401 creator A5060555082 @default.
• W2027655401 creator A5077216879 @default.
• W2027655401 creator A5079083200 @default.
• W2027655401 creator A5084290832 @default.
• W2027655401 date "2001-12-25" @default.
• W2027655401 modified "2023-10-11" @default.
• W2027655401 title "Affinity Purification and Partial Characterization of the Zonulin/Zonula Occludens Toxin (Zot) Receptor from Human Brain" @default.
• W2027655401 cites W1508137680 @default.
• W2027655401 cites W1568619250 @default.
• W2027655401 cites W1824585754 @default.
• W2027655401 cites W1986887962 @default.
• W2027655401 cites W198810393 @default.
• W2027655401 cites W2023684878 @default.
• W2027655401 cites W2026359714 @default.
• W2027655401 cites W2031503260 @default.
• W2027655401 cites W2037409426 @default.
• W2027655401 cites W2042220177 @default.
• W2027655401 cites W2049803975 @default.
• W2027655401 cites W2056775019 @default.
• W2027655401 cites W2089020335 @default.
• W2027655401 cites W2099729368 @default.
• W2027655401 cites W2102527427 @default.
• W2027655401 cites W2129214779 @default.
• W2027655401 cites W2134625663 @default.
• W2027655401 cites W2154251920 @default.
• W2027655401 cites W2159393409 @default.
• W2027655401 cites W2188983291 @default.
• W2027655401 cites W2339873058 @default.
• W2027655401 cites W2350887166 @default.
• W2027655401 cites W2430484008 @default.
• W2027655401 cites W2476763657 @default.
• W2027655401 cites W2489093650 @default.
• W2027655401 cites W2500778935 @default.
• W2027655401 doi "https://doi.org/10.1046/j.1471-4159.2000.0740320.x" @default.
• W2027655401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10617135" @default.
• W2027655401 hasPublicationYear "2001" @default.
• W2027655401 type Work @default.
• W2027655401 sameAs 2027655401 @default.
• W2027655401 citedByCount "55" @default.
• W2027655401 countsByYear W20276554012012 @default.
• W2027655401 countsByYear W20276554012013 @default.
• W2027655401 countsByYear W20276554012014 @default.
• W2027655401 countsByYear W20276554012015 @default.
• W2027655401 countsByYear W20276554012016 @default.
• W2027655401 countsByYear W20276554012017 @default.
• W2027655401 countsByYear W20276554012020 @default.
• W2027655401 countsByYear W20276554012021 @default.
• W2027655401 countsByYear W20276554012022 @default.
• W2027655401 countsByYear W20276554012023 @default.
• W2027655401 crossrefType "journal-article" @default.
• W2027655401 hasAuthorship W2027655401A5005895756 @default.
• W2027655401 hasAuthorship W2027655401A5046930712 @default.
• W2027655401 hasAuthorship W2027655401A5060555082 @default.
• W2027655401 hasAuthorship W2027655401A5077216879 @default.
• W2027655401 hasAuthorship W2027655401A5079083200 @default.
• W2027655401 hasAuthorship W2027655401A5084290832 @default.
• W2027655401 hasBestOaLocation W20276554011 @default.
• W2027655401 hasConcept C169760540 @default.
• W2027655401 hasConcept C170493617 @default.
• W2027655401 hasConcept C177779419 @default.
• W2027655401 hasConcept C2778402981 @default.
• W2027655401 hasConcept C2778597717 @default.
• W2027655401 hasConcept C529278444 @default.
• W2027655401 hasConcept C55493867 @default.
• W2027655401 hasConcept C79879829 @default.
• W2027655401 hasConcept C86803240 @default.
• W2027655401 hasConcept C95444343 @default.
• W2027655401 hasConceptScore W2027655401C169760540 @default.
• W2027655401 hasConceptScore W2027655401C170493617 @default.
• W2027655401 hasConceptScore W2027655401C177779419 @default.
• W2027655401 hasConceptScore W2027655401C2778402981 @default.
• W2027655401 hasConceptScore W2027655401C2778597717 @default.
• W2027655401 hasConceptScore W2027655401C529278444 @default.
• W2027655401 hasConceptScore W2027655401C55493867 @default.
• W2027655401 hasConceptScore W2027655401C79879829 @default.
• W2027655401 hasConceptScore W2027655401C86803240 @default.
• W2027655401 hasConceptScore W2027655401C95444343 @default.
• W2027655401 hasIssue "1" @default.
• W2027655401 hasLocation W20276554011 @default.
• W2027655401 hasLocation W20276554012 @default.
• W2027655401 hasOpenAccess W2027655401 @default.
• W2027655401 hasPrimaryLocation W20276554011 @default.
• W2027655401 hasRelatedWork W1929386789 @default.
• W2027655401 hasRelatedWork W2017459998 @default.
• W2027655401 hasRelatedWork W2034887716 @default.
• W2027655401 hasRelatedWork W2036400124 @default.
• W2027655401 hasRelatedWork W2100308259 @default.
• W2027655401 hasRelatedWork W2323347584 @default.
• W2027655401 hasRelatedWork W2356872707 @default.
• W2027655401 hasRelatedWork W27662948 @default.
• W2027655401 hasRelatedWork W4205719280 @default.
• W2027655401 hasRelatedWork W53624447 @default.
• W2027655401 hasVolume "74" @default.
• W2027655401 isParatext "false" @default.

• next