Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027662007> ?p ?o ?g. }
- W2027662007 endingPage "769" @default.
- W2027662007 startingPage "746" @default.
- W2027662007 abstract "Abstract Innovation in basic and applied science has brought radiotracers to fruition as diagnostics. Non‐invasive, longitudinal, and quantifiable molecular imaging is the key to diagnosing and monitoring numerous illnesses, with more to come from characterization of the clinical relevance of findings from genomics research. Radiotracers enable real‐time in vivo studies of the effects of drug candidates on receptors, pathways, pharmacodynamics, and clinically relevant endpoints, thereby providing both early detection of pathophysiology to enable early intervention, and then monitoring of treatment responses to enable individualization of treatment regimens. We review developments which have translated imaging from ‘bench to bedside’, or ‘biomarkers to diagnostics’. Notable developments include (1) synthesis methods for rapid 11 C labeling of biomolecules to high specific radioactivity; (2) ligand‐binding assays for screening molecular imaging agents rather than drugs; (3) in vivo imaging of radiotracers in animals; (4) discovering the imaging advantages of 99m Tc, 11 C, and 18 F; (5) co‐registration and automated quantitative assessment of high spatial resolution CT and MR images with molecular images from PET for longitudinal studies of treatment effect. Copyright © 2007 John Wiley & Sons, Ltd." @default.
- W2027662007 created "2016-06-24" @default.
- W2027662007 creator A5010315360 @default.
- W2027662007 creator A5036175913 @default.
- W2027662007 creator A5050853855 @default.
- W2027662007 creator A5060773099 @default.
- W2027662007 creator A5061049141 @default.
- W2027662007 creator A5073114803 @default.
- W2027662007 creator A5078923324 @default.
- W2027662007 creator A5079058585 @default.
- W2027662007 date "2007-08-01" @default.
- W2027662007 modified "2023-09-27" @default.
- W2027662007 title "The imaging continuum: bench to biomarkers to diagnostics" @default.
- W2027662007 cites W123458585 @default.
- W2027662007 cites W1493302394 @default.
- W2027662007 cites W1587689095 @default.
- W2027662007 cites W1601897860 @default.
- W2027662007 cites W182669748 @default.
- W2027662007 cites W1963642506 @default.
- W2027662007 cites W1964790283 @default.
- W2027662007 cites W1968910136 @default.
- W2027662007 cites W1969519961 @default.
- W2027662007 cites W1969878437 @default.
- W2027662007 cites W1970648991 @default.
- W2027662007 cites W1971411080 @default.
- W2027662007 cites W1972816877 @default.
- W2027662007 cites W1973243290 @default.
- W2027662007 cites W1973600768 @default.
- W2027662007 cites W1975174668 @default.
- W2027662007 cites W1975383146 @default.
- W2027662007 cites W1976630512 @default.
- W2027662007 cites W1978465883 @default.
- W2027662007 cites W1979060895 @default.
- W2027662007 cites W1979525257 @default.
- W2027662007 cites W1980260496 @default.
- W2027662007 cites W1981542177 @default.
- W2027662007 cites W1982474740 @default.
- W2027662007 cites W1985651705 @default.
- W2027662007 cites W1988290043 @default.
- W2027662007 cites W1988705707 @default.
- W2027662007 cites W1989790390 @default.
- W2027662007 cites W1992270670 @default.
- W2027662007 cites W1992768671 @default.
- W2027662007 cites W1995655436 @default.
- W2027662007 cites W1999404237 @default.
- W2027662007 cites W1999560679 @default.
- W2027662007 cites W2000149891 @default.
- W2027662007 cites W2000278109 @default.
- W2027662007 cites W2000980666 @default.
- W2027662007 cites W2007964603 @default.
- W2027662007 cites W2011338237 @default.
- W2027662007 cites W2015343479 @default.
- W2027662007 cites W2015390581 @default.
- W2027662007 cites W2019388537 @default.
- W2027662007 cites W2023344575 @default.
- W2027662007 cites W2025937906 @default.
- W2027662007 cites W2029342376 @default.
- W2027662007 cites W2031943657 @default.
- W2027662007 cites W2032646226 @default.
- W2027662007 cites W2034576007 @default.
- W2027662007 cites W2035787884 @default.
- W2027662007 cites W2037728152 @default.
- W2027662007 cites W2041339548 @default.
- W2027662007 cites W2042963060 @default.
- W2027662007 cites W2044786521 @default.
- W2027662007 cites W2049128343 @default.
- W2027662007 cites W2052309056 @default.
- W2027662007 cites W2054765812 @default.
- W2027662007 cites W2055934965 @default.
- W2027662007 cites W2056823516 @default.
- W2027662007 cites W2057126679 @default.
- W2027662007 cites W2058980733 @default.
- W2027662007 cites W2059176396 @default.
- W2027662007 cites W2059469137 @default.
- W2027662007 cites W2059976248 @default.
- W2027662007 cites W2060781907 @default.
- W2027662007 cites W2062555445 @default.
- W2027662007 cites W2066119033 @default.
- W2027662007 cites W2067194146 @default.
- W2027662007 cites W2068812502 @default.
- W2027662007 cites W2068855820 @default.
- W2027662007 cites W2069464864 @default.
- W2027662007 cites W2073200751 @default.
- W2027662007 cites W2077013183 @default.
- W2027662007 cites W2081996276 @default.
- W2027662007 cites W2082298563 @default.
- W2027662007 cites W2083206079 @default.
- W2027662007 cites W2083971412 @default.
- W2027662007 cites W2084347011 @default.
- W2027662007 cites W2086367721 @default.
- W2027662007 cites W2088402933 @default.
- W2027662007 cites W2088556738 @default.
- W2027662007 cites W2090203522 @default.
- W2027662007 cites W2090306035 @default.
- W2027662007 cites W2090816585 @default.
- W2027662007 cites W2091243484 @default.
- W2027662007 cites W2091850265 @default.
- W2027662007 cites W2091980265 @default.