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- W2027664694 abstract "Background Lipoprotein(a) (Lp[a]) is known to inhibit the fibrinolysis system and promote thrombus formation. Hypothesis We retrospectively investigated the influences of Lp(a) on infarct-related artery patency in the early phase of acute myocardial infarction (AMI). Methods In 144 patients with ST-segment elevation, myocardial, coronary angiography (CAG) was performed within 12 h of the onset of symptoms. Subjects were divided into 2 groups according to the thrombolysis in myocardial infaction (TIMI) grade, Group I (TIMI 0–1, n = 94) versus Group II (TIMI 2–3, n = 50). The Gensini score and 0- to 3-vessel disease score estimated the severity and extent of coronary artery disease (CAD), respectively. Lp(a), lipid profile and c-reactive protein (CRP) were measured before any medications including thrombolytics were given. Results The Lp(a) level was higher in Group I than in Group II. There was a weak correlation between Lp(a) level and Gensini score. By multivariate logistic regression analysis, a Lp(a) level was a predictor of infarct-related artery patency in the early phase of AMI. There were no significant differences in the location of the infarct-related arteries, extent of CAD, time from pain to CAG, number of risk factors, and hs-CRP values between the 2 groups. Conclusion The Lp(a) level was significantly higher in patients with persistent occlusion compared with those with spontaneous recanalization of infarct-related arteries in the early phase of AMI. Copyright © 2008 Wiley Periodicals, Inc." @default.
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- W2027664694 date "2008-01-01" @default.
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- W2027664694 title "Relationship Between Lipoprotein(a) and Spontaneous Recanalization of Infarct-related Arteries in the Early Phase of Acute Myocardial Infarction" @default.
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- W2027664694 doi "https://doi.org/10.1002/clc.20143" @default.
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