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• W2027667214 abstract "No AccessJournal of UrologyAdult Urology: Urolithiasis/Endourology1 Jan 2005EFFECTS OF URINARY PROTHROMBIN FRAGMENT 1 IN THE FORMATION OF CALCIUM OXALATE CALCULUS JIHONG LIU, JUNHUI CHEN, TAO WANG, SHAOGANG WANG, and ZHANGQUN YE JIHONG LIUJIHONG LIU More articles by this author , JUNHUI CHENJUNHUI CHEN More articles by this author , TAO WANGTAO WANG More articles by this author , SHAOGANG WANGSHAOGANG WANG More articles by this author , and ZHANGQUN YEZHANGQUN YE More articles by this author View All Author Informationhttps://doi.org/10.1097/01.ju.0000146847.24571.c8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We investigated the effects of urinary prothrombin fragment 1 in the formation of calcium oxalate urolithiasis. Materials and Methods: Fresh urine and renal parenchyma from patients with calcium oxalate calculus and normal controls were collected. Urinary prothrombin fragment 1 was isolated and purified from urine. It was identified by sodium dodecyl sulfide-polyacrylamide gel electrophoresis and analysis of its first 13 N-amino acids. The inhibitory activity of urinary prothrombin fragment 1 on calcium oxalate crystal growth was tested by the seeded crystallization technique. Meanwhile, the γ-carboxyglutamic acid composition of urinary prothrombin fragment 1 was analyzed by a previously described method and genetic mutation of the γ-carboxyglutamic acid domain of urinary prothrombin fragment 1 from renal parenchyma was detected by polymerase chain reaction-single strand conformational polymorphism sequencing. Results: The γ-carboxyglutamic acid composition of urinary prothrombin fragment 1 was significantly decreased from normal (24.4 to 1.7 mol/1,000 amino acids) in patients with calcium oxalate calculus. The mean growth index ± SD of urinary prothrombin fragment 1 to calcium oxalate crystals was 42.3 ± 4.2 compared with the normal index of 19.2 ± 2.8 (p <0.01). The polymerase chain reaction-single strand conformational polymorphism sequencing technique revealed no genetic mutation of the γ-carboxyglutamic acid domain of urinary prothrombin fragment 1 in patients with calcium oxalate calculus. Conclusions: The γ-carboxyglutamic acid composition of urinary prothrombin fragment 1 as well as its ability to inhibit calcium oxalate crystal growth was significantly decreased in patients with calcium oxalate calculus. This was not caused by genetic mutation of the γ-carboxyglutamic acid domain of urinary prothrombin fragment 1. It is important to elucidate the mechanisms of calcium oxalate stones in view of urinary prothrombin fragment 1. References 1 : Analysis of renal calculous matrix compared with some other matrix materials and with uromucoid. Arch Biochem Biophys1959; 82: 455. Google Scholar 2 : Blood coagulation proteins and urolithiasis are linked: crystal matrix protein is the F1 activation peptide of human prothrombin. Br J Urol1995; 75: 712. Google Scholar 3 : Inhibition of calcium oxalate crystal growth and aggregation by prothrombin and its fragments in vitro: relationship between protein structure and inhibitory activity. Eur J Biochem1999; 263: 50. Google Scholar 4 : Inhibition of growth and aggregation of calcium oxalate crystals in vitro—a comparison of four human proteins. Eur J Biochem1998; 253: 637. Google Scholar 5 : Localization of renal vitamin K-dependent gamma-glutamyl carboxylase to tubule cells. J Biol Chem1982; 257: 11037. Google Scholar 6 : Gene expression of prothrombin in the human kidney and its potential relevance to kidney stone disease. Br J Urol1998; 81: 666. Google Scholar 7 : Determination of protein-bound urinary gamma-carboxyglutamic acid in calcium nephrolithiasis. Clin Chim Acta1991; 204: 43. Google Scholar 8 : Quantitative determination of gamma-carboxyglutamic acid in proteins. Anal Biochem1977; 80: 212. Google Scholar 9 : Growth of calcium oxalate crystals. I. A model for urinary stone growth. Invest Urol1975; 13: 31. Google Scholar 10 : Nucleotide sequence of the gene for human prothrombin. Biochemistry1987; 26: 6165. Google Scholar 11 : Isolation and partial characterization of crystal matrix protein as a potent inhibitor of calcium oxalate crystal aggregation: evidence of activation peptide of human prothrombin. Urol Res1994; 22: 45. Google Scholar 12 : The urinary F1 activation peptide of human prothrombin is a potent inhibitor of calcium oxalate crystallization in undiluted human urine in vitro. Clin Sci1995; 89: 533. Google Scholar 13 : Inclusion of proteins into calcium oxalate crystals precipitated from human urine: a highly selective phenomenon. Clin Chem1991; 37: 1589. Google Scholar 14 : Further evidence linking urolithiasis and blood coagulation: urinary prothrombin fragment 1 is present in stone matrix. Kidney Int1996; 49: 880. Google Scholar 15 : Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid. Blood1999; 93: 1798. Google Scholar 16 : Molecular basis of vitamin K-dependent gamma-carboxylation. Blood1990; 75: 1753. Google Scholar From the Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China© 2005 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 173Issue 1January 2005Page: 113-116 Advertisement Copyright & Permissions© 2005 by American Urological Association, Inc.Keywordscalcium oxalatecalculusprothrombin fragment 1kidney1-carboxyglutamic acidMetricsAuthor Information JIHONG LIU More articles by this author JUNHUI CHEN More articles by this author TAO WANG More articles by this author SHAOGANG WANG More articles by this author ZHANGQUN YE More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2027667214 title "EFFECTS OF URINARY PROTHROMBIN FRAGMENT 1 IN THE FORMATION OF CALCIUM OXALATE CALCULUS" @default.
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