FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027672602> ?p ?o ?g. }

• W2027672602 endingPage "165" @default.
• W2027672602 startingPage "153" @default.
• W2027672602 abstract "A major problem after clinical autologous islet transplantation (AIT) is the difficulty in achieving insulin independence. To follow up on our demonstration in a murine model that high-mobility group box 1 (HMGB1) was released from islets and involved in early loss of transplanted islets, we tested the role of HMGB1 in clinical AIT. Serum HMGB1 levels from 15 AIT patients were significantly elevated during islet infusion (7.6 ± 1.2 ng/ml) and 24 h after infusion (8.0 ± 1.4 ng/ml) compared to admission levels (2.4 ± 0.6 ng/ml). The first elevation of HMGB1 was associated with islet damage, but the later elevation was not. The change in the HMGB1 level from admission to first peak (ΔHMGB1) was significantly higher in the AIT group (8.1 ± 1.1 ng/ml) than in the pancreatectomy-only control (2.2 ± 0.5 ng/ml) (p < 0.05). Circulating serum levels of soluble receptor for advanced glycation end products (sRAGE) were also elevated during islet infusion. In vitro studies demonstrated that damaged human islets released HMGB1 but not sRAGE. In terms of outcomes, the insulin-free group showed significantly lower ΔHMGB1 (5.2 ± 0.6 ng/ml) and higher ΔsRAGE (2.3 ± 0.6 ng/ml) than the insulin-dependent group (10.6 ± 1.9 ng/ml and 0.7 ± 0.2 ng/ml, respectively). The ΔHMGB1 correlated with the number of white blood cell, IP-10, EGF, and eotaxin. In conclusion, serum HMGB1 was elevated in AIT and could be associated with inflammatory reactions that deteriorate islet engraftment. Therefore, anti-HMGB1 therapy might be a candidate for further improving the outcomes of clinical AIT." @default.
• W2027672602 created "2016-06-24" @default.
• W2027672602 creator A5003816957 @default.
• W2027672602 creator A5006946051 @default.
• W2027672602 creator A5009641276 @default.
• W2027672602 creator A5010934625 @default.
• W2027672602 creator A5012957428 @default.
• W2027672602 creator A5013965216 @default.
• W2027672602 creator A5017433482 @default.
• W2027672602 creator A5018023752 @default.
• W2027672602 creator A5019865591 @default.
• W2027672602 creator A5040899091 @default.
• W2027672602 creator A5056116849 @default.
• W2027672602 creator A5058185889 @default.
• W2027672602 creator A5073576456 @default.
• W2027672602 creator A5078861466 @default.
• W2027672602 creator A5086978977 @default.
• W2027672602 date "2014-03-01" @default.
• W2027672602 modified "2023-09-28" @default.
• W2027672602 title "Evation of High-Mobility Group Box 1 after Clinical Autologous Islet Transplantation and Its Inverse Correlation with Outcomes" @default.
• W2027672602 cites W1207740807 @default.
• W2027672602 cites W1482230619 @default.
• W2027672602 cites W1552445206 @default.
• W2027672602 cites W1967434989 @default.
• W2027672602 cites W1969925621 @default.
• W2027672602 cites W1974238448 @default.
• W2027672602 cites W1983701023 @default.
• W2027672602 cites W1985236743 @default.
• W2027672602 cites W1986180590 @default.
• W2027672602 cites W1990814244 @default.
• W2027672602 cites W1992484293 @default.
• W2027672602 cites W1996423906 @default.
• W2027672602 cites W2013327244 @default.
• W2027672602 cites W2018653121 @default.
• W2027672602 cites W2022798707 @default.
• W2027672602 cites W2026428131 @default.
• W2027672602 cites W2042204493 @default.
• W2027672602 cites W2046290067 @default.
• W2027672602 cites W2047233152 @default.
• W2027672602 cites W2094724346 @default.
• W2027672602 cites W2097391811 @default.
• W2027672602 cites W2106949373 @default.
• W2027672602 cites W2108380410 @default.
• W2027672602 cites W2112407769 @default.
• W2027672602 cites W2123637649 @default.
• W2027672602 cites W2129902595 @default.
• W2027672602 cites W2138067618 @default.
• W2027672602 cites W2141544811 @default.
• W2027672602 cites W2143998429 @default.
• W2027672602 cites W2147259348 @default.
• W2027672602 cites W2148715056 @default.
• W2027672602 cites W2149036744 @default.
• W2027672602 cites W2164714222 @default.
• W2027672602 cites W2321023578 @default.
• W2027672602 cites W274927353 @default.
• W2027672602 cites W4211115676 @default.
• W2027672602 doi "https://doi.org/10.3727/096368912x658980" @default.
• W2027672602 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4096134" @default.
• W2027672602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23211332" @default.
• W2027672602 hasPublicationYear "2014" @default.
• W2027672602 type Work @default.
• W2027672602 sameAs 2027672602 @default.
• W2027672602 citedByCount "39" @default.
• W2027672602 countsByYear W20276726022013 @default.
• W2027672602 countsByYear W20276726022014 @default.
• W2027672602 countsByYear W20276726022015 @default.
• W2027672602 countsByYear W20276726022016 @default.
• W2027672602 countsByYear W20276726022017 @default.
• W2027672602 countsByYear W20276726022018 @default.
• W2027672602 countsByYear W20276726022019 @default.
• W2027672602 countsByYear W20276726022020 @default.
• W2027672602 countsByYear W20276726022021 @default.
• W2027672602 countsByYear W20276726022022 @default.
• W2027672602 countsByYear W20276726022023 @default.
• W2027672602 crossrefType "journal-article" @default.
• W2027672602 hasAuthorship W2027672602A5003816957 @default.
• W2027672602 hasAuthorship W2027672602A5006946051 @default.
• W2027672602 hasAuthorship W2027672602A5009641276 @default.
• W2027672602 hasAuthorship W2027672602A5010934625 @default.
• W2027672602 hasAuthorship W2027672602A5012957428 @default.
• W2027672602 hasAuthorship W2027672602A5013965216 @default.
• W2027672602 hasAuthorship W2027672602A5017433482 @default.
• W2027672602 hasAuthorship W2027672602A5018023752 @default.
• W2027672602 hasAuthorship W2027672602A5019865591 @default.
• W2027672602 hasAuthorship W2027672602A5040899091 @default.
• W2027672602 hasAuthorship W2027672602A5056116849 @default.
• W2027672602 hasAuthorship W2027672602A5058185889 @default.
• W2027672602 hasAuthorship W2027672602A5073576456 @default.
• W2027672602 hasAuthorship W2027672602A5078861466 @default.
• W2027672602 hasAuthorship W2027672602A5086978977 @default.
• W2027672602 hasBestOaLocation W20276726023 @default.
• W2027672602 hasConcept C104317684 @default.
• W2027672602 hasConcept C126322002 @default.
• W2027672602 hasConcept C134018914 @default.
• W2027672602 hasConcept C147990577 @default.
• W2027672602 hasConcept C165220095 @default.
• W2027672602 hasConcept C16685009 @default.
• W2027672602 hasConcept C170493617 @default.

• next