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• W2027681403 abstract "Lymphoplasmacytic neoplasms cause a wide range of injuries to the kidney exemplified by light chain cast nephropathy and amyloidosis. Filtered paraproteins can also accumulate within kidney cells and cause direct cytotoxic injury. Rarely, paraproteins that are resistant to proteolysis can crystallize within proximal tubules and cause acute tubular injury. In contrast, accumulation of crystallized paraproteins in other kidney cells, especially podocytes, is exceptional. Here, we report the finding of crystalline inclusions within podocytes and proximal tubules in a patient who presented with a combined nephrotic syndrome and Fanconi syndrome. Further workup revealed previously unsuspected multiple myeloma and elevated serum free light chains, highlighting the protean presentation of paraprotein-mediated injuries to the kidney." @default.
• W2027681403 created "2016-06-24" @default.
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• W2027681403 date "2014-04-01" @default.
• W2027681403 modified "2023-10-03" @default.
• W2027681403 title "Combined crystalline podocytopathy and tubulopathy associated with multiple myeloma" @default.
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• W2027681403 doi "https://doi.org/10.1016/j.humpath.2013.10.007" @default.
• W2027681403 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24439928" @default.
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