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• W2027694075 abstract "1 The effects of acetylcholine (ACh) on membrane potential, relaxation and cyclic GMP levels were compared to the NO donor l-nitrosocysteine (Cys-NO) in segments of guinea-pig coronary artery. 2 ACh and Cys-NO produced concentration-dependent relaxations of muscles contracted with the H1 receptor agonist, 2-(2-aminoethyl)pyridine (AEP, 0.35 mm). The relaxation to ACh was unchanged in the presence of NG-monomethyl-l-arginine (l-NMMA; 350 μm) or indomethacin (3 μm). 3 Oxyhaemoglobin (HbO; 20 μm) alone or in combination with l-NMMA increased the EC50 for ACh-induced relaxation whereas relaxation with Cys-NO was almost completely abolished with HbO. 4 Scorpion venom (SV; 8.7 μg ml−1) increased the EC50 for relaxation with ACh but not Cys-NO. Combined l-NMMA, HbO and SV produced nearly complete abolition of ACh-induced relaxations. 5 Basal cyclic GMP levels (i.e., 20 pmol mg−1protein) were significantly increased following addition of either ACh (190 pmol mg−1protein) or Cys-NO (240 pmol mg−1protein). l-NMMA significantly reduced the rise of cyclic GMP with ACh but not Cys-NO. In contrast, SV did not significantly reduce the rise in cyclic GMP produced with ACh. In the combined presence of l-NMMA and HbO neither ACh nor Cys-NO produced a significant increase in cyclic GMP levels. 6 ACh gave rise to significantly greater membrane hyperpolarization than Cys-NO both in the presence and absence of AEP. Combined l-NMMA and HbO did not reduce the amplitude of hyperpolarization with ACh. 7 These data indicate that some but not all of the actions of ACh in the coronary artery can be mimicked by the NO donor, Cys-NO, suggesting that ACh releases NO as well as a second hyperpolarizing factor (i.e., EDHF). Release of NO results in a large increase in tissue cyclic GMP levels and minimal change in membrane potential whereas release of EDHF results in a large membrane hyperpolarization which is independent of changes in tissue cyclic GMP levels. Both of these pathways appear to contribute to relaxation throughout the entire ACh concentration-relaxation relationship." @default.
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• W2027694075 date "1994-04-01" @default.
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• W2027694075 title "Cyclic GMP-independent relaxation and hyperpolarization with acetylcholine in guinea-pig coronary artery" @default.
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• W2027694075 doi "https://doi.org/10.1111/j.1476-5381.1994.tb14851.x" @default.
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