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- W2027694906 abstract "(3R)-3-[N-(tert-Butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid 7a has been synthesized by an asymmetric hydrogenation of enamine ester 3 using chiral ferrocenyl ligands I and II in conjunction with [Rh(COD)Cl]2. The direct reduction of 3 provides amino ester 1b in 93% ee, which was isolated as an (S)-camphorsulfonic acid salt to upgrade the enantiomeric excess to >99%. A more concise approach was developed involving the in situ protection of 1b using di-tert-butyldicarbonate. This approach provided the desired N-Boc amino ester 7b directly from the hydrogenation with 97% ee, which was upgraded to >99% ee upon crystallization." @default.
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- W2027694906 date "2006-01-01" @default.
- W2027694906 modified "2023-10-18" @default.
- W2027694906 title "Application of the asymmetric hydrogenation of enamines to the preparation of a beta-amino acid pharmacophore" @default.
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- W2027694906 doi "https://doi.org/10.1016/j.tetasy.2005.12.016" @default.
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