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• W2027699993 abstract "CD4 T cells potentiate the inflammatory or humoral immune response through the action of Th1 and Th2 cells, respectively. The molecular basis of the differentiation of these cells from naive T cell precursors is, however, unclear. We found that GATA-3 was selectively expressed in Th2 cells. GATA-3 is expressed at a high level in naive, freshly activated T cells and Th2 lineage cells, but subsides to a minimal level in Th1 lineage cells as naive cells commit to their Th subset. Antisense GATA-3 inhibited the expression of all Th2 cytokine genes in the Th2 clone D10. GATA-3 directly activated an IL-4 promoter-luciferase reporter gene in M12 cells. In transgenic mice, elevated GATA-3 in CD4 T cells caused Th2 cytokine gene expression in developing Th1 cells. Thus, GATA-3 is necessary and sufficient for Th2 cytokine gene expression." @default.
• W2027699993 created "2016-06-24" @default.
• W2027699993 creator A5013890373 @default.
• W2027699993 creator A5064443404 @default.
• W2027699993 date "1997-05-01" @default.
• W2027699993 modified "2023-10-14" @default.
• W2027699993 title "The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells" @default.
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• W2027699993 doi "https://doi.org/10.1016/s0092-8674(00)80240-8" @default.
• W2027699993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9160750" @default.
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