FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027702949> ?p ?o ?g. }

• W2027702949 endingPage "1098" @default.
• W2027702949 startingPage "1090" @default.
• W2027702949 abstract "Prior research has suggested reductions in the density of serotonin transporter (SERT) binding sites in blood platelets and post-mortem brain tissue of depressed patients. We sought to determine whether patients with unipolar major depression have diminished SERT availability as assessed by both brainstem [123I] beta-CIT SPECT and platelet [3H]paroxetine binding.Drug-free depressed and healthy subjects were injected with 211 +/- 22 MBq [123I] beta-CIT and imaged 24 +/- 2 h later under equilibrium conditions. A ratio of specific to nonspecific brain uptake (V3 = (brainstem-occipital)/occipital), a measure proportional to the binding potential (Bmax/Kd), was used for all comparisons.Results showed a statistically significant reduction in brainstem V3 values in depressed as compared to healthy subjects (3.1 +/- .9 vs. 3.8 +/- .8, p = .02). Platelet [3H]paroxetine binding was not altered (Bmax = 2389 +/- 484 vs. 2415 +/- 538 fmol/mg protein, p = .91) and was not significantly correlated with brainstem [123I] beta-CIT binding (r = -0.14, p = .48).These data are the first to suggest reductions in the density of brain SERT binding sites in living depressed patients. These findings provide further support for a preeminent role for alterations in serotonergic neurons in the pathophysiology of depression." @default.
• W2027702949 created "2016-06-24" @default.
• W2027702949 creator A5012699156 @default.
• W2027702949 creator A5029861832 @default.
• W2027702949 creator A5030853392 @default.
• W2027702949 creator A5031601763 @default.
• W2027702949 creator A5033012813 @default.
• W2027702949 creator A5037185919 @default.
• W2027702949 creator A5037210460 @default.
• W2027702949 creator A5037230816 @default.
• W2027702949 creator A5037791361 @default.
• W2027702949 creator A5057146350 @default.
• W2027702949 creator A5064797758 @default.
• W2027702949 creator A5065813510 @default.
• W2027702949 creator A5079125204 @default.
• W2027702949 creator A5081621207 @default.
• W2027702949 date "1998-12-01" @default.
• W2027702949 modified "2023-09-27" @default.
• W2027702949 title "Reduced brain serotonin transporter availability in major depression as measured by [123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane and single photon emission computed tomography" @default.
• W2027702949 cites W1775749144 @default.
• W2027702949 cites W1894736765 @default.
• W2027702949 cites W1962934739 @default.
• W2027702949 cites W1974081542 @default.
• W2027702949 cites W1975902833 @default.
• W2027702949 cites W1977358254 @default.
• W2027702949 cites W1983066926 @default.
• W2027702949 cites W1987473614 @default.
• W2027702949 cites W1990147030 @default.
• W2027702949 cites W1993675061 @default.
• W2027702949 cites W1996797606 @default.
• W2027702949 cites W2003817082 @default.
• W2027702949 cites W2005534453 @default.
• W2027702949 cites W2006441699 @default.
• W2027702949 cites W2006715508 @default.
• W2027702949 cites W2007510516 @default.
• W2027702949 cites W2010928495 @default.
• W2027702949 cites W2013778485 @default.
• W2027702949 cites W2014166296 @default.
• W2027702949 cites W2016762802 @default.
• W2027702949 cites W2017284729 @default.
• W2027702949 cites W2019924051 @default.
• W2027702949 cites W2023574802 @default.
• W2027702949 cites W2034460244 @default.
• W2027702949 cites W2045722213 @default.
• W2027702949 cites W2046942790 @default.
• W2027702949 cites W2055779291 @default.
• W2027702949 cites W2060724489 @default.
• W2027702949 cites W2067495470 @default.
• W2027702949 cites W2079477007 @default.
• W2027702949 cites W2093102512 @default.
• W2027702949 cites W2106095564 @default.
• W2027702949 cites W2114613490 @default.
• W2027702949 cites W2115045018 @default.
• W2027702949 cites W2121887890 @default.
• W2027702949 cites W2132072846 @default.
• W2027702949 cites W2133746049 @default.
• W2027702949 cites W2134705697 @default.
• W2027702949 cites W2136619214 @default.
• W2027702949 cites W2160874664 @default.
• W2027702949 cites W2409700012 @default.
• W2027702949 doi "https://doi.org/10.1016/s0006-3223(98)00272-8" @default.
• W2027702949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9836013" @default.
• W2027702949 hasPublicationYear "1998" @default.
• W2027702949 type Work @default.
• W2027702949 sameAs 2027702949 @default.
• W2027702949 citedByCount "461" @default.
• W2027702949 countsByYear W20277029492012 @default.
• W2027702949 countsByYear W20277029492013 @default.
• W2027702949 countsByYear W20277029492014 @default.
• W2027702949 countsByYear W20277029492015 @default.
• W2027702949 countsByYear W20277029492016 @default.
• W2027702949 countsByYear W20277029492017 @default.
• W2027702949 countsByYear W20277029492018 @default.
• W2027702949 countsByYear W20277029492019 @default.
• W2027702949 countsByYear W20277029492020 @default.
• W2027702949 countsByYear W20277029492021 @default.
• W2027702949 countsByYear W20277029492022 @default.
• W2027702949 countsByYear W20277029492023 @default.
• W2027702949 crossrefType "journal-article" @default.
• W2027702949 hasAuthorship W2027702949A5012699156 @default.
• W2027702949 hasAuthorship W2027702949A5029861832 @default.
• W2027702949 hasAuthorship W2027702949A5030853392 @default.
• W2027702949 hasAuthorship W2027702949A5031601763 @default.
• W2027702949 hasAuthorship W2027702949A5033012813 @default.
• W2027702949 hasAuthorship W2027702949A5037185919 @default.
• W2027702949 hasAuthorship W2027702949A5037210460 @default.
• W2027702949 hasAuthorship W2027702949A5037230816 @default.
• W2027702949 hasAuthorship W2027702949A5037791361 @default.
• W2027702949 hasAuthorship W2027702949A5057146350 @default.
• W2027702949 hasAuthorship W2027702949A5064797758 @default.
• W2027702949 hasAuthorship W2027702949A5065813510 @default.
• W2027702949 hasAuthorship W2027702949A5079125204 @default.
• W2027702949 hasAuthorship W2027702949A5081621207 @default.
• W2027702949 hasBestOaLocation W20277029491 @default.
• W2027702949 hasConcept C126322002 @default.
• W2027702949 hasConcept C134018914 @default.
• W2027702949 hasConcept C139719470 @default.
• W2027702949 hasConcept C15744967 @default.

• next