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- W2027702999 abstract "Asthma is a hereditary disease associated with IgE-mediated reaction. Whether maternal atopy and paternal atopy have different impacts on perinatal IgE production and asthma development remains unclear. This paper reviews and summarizes the effects of maternal and paternal atopy on the developmental aspects of IgE production and asthma. Maternal atopy affects both pre- and postnatal IgE production, whereas paternal atopy mainly affects the latter. Maternally transmitted genes GSTP1 and FceRI-beta are associated with lung function and allergic sensitization, respectively. In IgE production and asthma development, the maternal influence on gene-environment interaction is greater than paternal influence. Maternal, paternal, and/or postnatal environmental modulation of allergic responses have been linked to epigenetic mechanisms, which may be good targets for early prevention of asthma." @default.
- W2027702999 created "2016-06-24" @default.
- W2027702999 creator A5042978263 @default.
- W2027702999 creator A5070883924 @default.
- W2027702999 creator A5076141316 @default.
- W2027702999 date "2012-01-01" @default.
- W2027702999 modified "2023-10-14" @default.
- W2027702999 title "Different Implications of Paternal and Maternal Atopy for Perinatal IgE Production and Asthma Development" @default.
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