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- W2027736900 abstract "Agonist-induced internalization of metabotropic glutamate receptors (mGluRs) plays an important role in neuronal signaling. Although internalization of mGluRs has been reported to be mediated by clathrin-dependent pathway, studies describing clathrin-independent pathways are emerging. Here, we report that agonist-induced internalization of mGluR1alpha is mediated by caveolin. We show that two caveolin-binding motifs of mGluR1alpha interact with caveolin1/2. Using cell surface-immunoprecipitation and total internal reflection fluorescence imaging, we found that agonist-induced internalization of mGluR1alpha is regulated by caveolin-binding motifs of the receptor in heterologous cells. Moreover, in the cerebellum, group I mGluR agonist dihydroxyphenylglycol increased the interaction of phosphorylated caveolin with mGluR1alpha. This interaction was blocked by methyl-beta-cyclodextrin, known to disrupt caveolin/caveolae-dependent signaling by cholesterol depletion. Methyl-beta-cyclodextrin also blocked the agonist-induced internalization of mGluR1alpha. Thus, these findings represent the evidence for agonist-induced internalization of mGluR1alpha via caveolin and suggest that caveolin might play a role in synaptic metaplasticity by regulating internalization of mGluR1alpha in the cerebellum." @default.
- W2027736900 created "2016-06-24" @default.
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- W2027736900 date "2009-09-14" @default.
- W2027736900 modified "2023-10-14" @default.
- W2027736900 title "Agonist-induced internalization of mGluR1α is mediated by caveolin" @default.
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- W2027736900 doi "https://doi.org/10.1111/j.1471-4159.2009.06289.x" @default.
- W2027736900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19627451" @default.
- W2027736900 hasPublicationYear "2009" @default.
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