FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027748124> ?p ?o ?g. }

• W2027748124 abstract "This issue of Journal of Thoracic Oncology includes two separate articles that have a lot of similarities.1,2 Both address the issue of what to do with patients that present with the synchronous finding of a primary lung cancer and an additional separate, yet similar lesion. The article by Finley et al.1 restricts its analysis to patients who were proven to have synchronous primary lung cancers, whereas the article by Kim et al.2 addresses patients who have one or more additional ground glass opacities (GGO), and the task of determining which of these additional lesions is malignant. These articles present a good opportunity to discuss the topic of how we should think of synchronous, separate nodules in patients with lung cancer. The article by Finley et al.1 has several unique features, starting with a new definition of what should be considered a second primary lung cancer. The widely used criteria proposed by Martini and Melamed3 in 1975 were empirically derived and have never been validated. An analysis of data suggests that for metachronous second primary lung cancers, a 4-year interval is better than the traditional 2-year interval.4,5 Finley et al. have added definitions to distinguish synchronous tumors, accepting them as second primary cancers if they are either of a different histologic type or subtype of adenocarcinoma. Because most of adenocarcinomas are of mixed subtypes, distinct tumors are defined by differing proportions of the subtypes. This distinction has been shown to correlate with genetic differences but has the advantage of being apparent by light microscopy.6 I believe that this definition will become the new standard, at least for synchronous tumors. Distinguishing tumors on the basis of genomic signatures remains costly, available only in research laboratories, is sometimes plagued by conflicting results,7–9 and, in fact, genetic features correlate quite well with details apparent by light microscopy.6,10 The study by Finley et al. also used careful staging of the patients to avoid considering patients as having synchronous second primary cancers if in fact they had evidence of metastases to distant sites or mediastinal nodes although full details are not explicit. Not all centers reporting on second primary lung cancers have used such a thorough evaluation, although this is recommended in the American College of Chest Physicians Lung Cancer guidelines.4,5 The survival observed in this study (5-year overall survival 55%) is better than most series of synchronous primary lung cancers (average 5-year survival 30%).11 Is this because of better patient selection (e.g., more careful staging)? Is this due to a changing spectrum of disease, with a greater proportion of more indolent tumors (e.g., due to computed tomography screening, increasing proportion of women or nonsmokers)? Or is this because we are seeing more of a different kind of non-small cell lung cancer that has a propensity for multifocal disease? Unfortunately, there is no information on recurrence patterns. This could shed light on whether we are dealing with “regular” lung cancers that have been carefully selected, in which case we should see primarily distant metastases among those patients that develop recurrent disease. However, if we are dealing with tumors that have a propensity to multifocal disease in the lungs, we would expect a high proportion of “local recur-" @default.
• W2027748124 created "2016-06-24" @default.
• W2027748124 creator A5019635887 @default.
• W2027748124 date "2010-02-01" @default.
• W2027748124 modified "2023-09-30" @default.
• W2027748124 title "Synchronous, Separate, and Similar" @default.
• W2027748124 cites W1158033259 @default.
• W2027748124 cites W1710915557 @default.
• W2027748124 cites W1977995498 @default.
• W2027748124 cites W1978408088 @default.
• W2027748124 cites W2008955969 @default.
• W2027748124 cites W2014546505 @default.
• W2027748124 cites W2021791101 @default.
• W2027748124 cites W2046902166 @default.
• W2027748124 cites W2052693403 @default.
• W2027748124 cites W2054678952 @default.
• W2027748124 cites W2056625156 @default.
• W2027748124 cites W2063759711 @default.
• W2027748124 cites W2076734146 @default.
• W2027748124 cites W2088720324 @default.
• W2027748124 cites W2092444137 @default.
• W2027748124 cites W2100976527 @default.
• W2027748124 cites W2105494983 @default.
• W2027748124 cites W2107017134 @default.
• W2027748124 cites W2118782779 @default.
• W2027748124 cites W2143410956 @default.
• W2027748124 cites W2156075862 @default.
• W2027748124 cites W2169174541 @default.
• W2027748124 cites W2525561873 @default.
• W2027748124 cites W3201353165 @default.
• W2027748124 doi "https://doi.org/10.1097/jto.0b013e3181c81500" @default.
• W2027748124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20101142" @default.
• W2027748124 hasPublicationYear "2010" @default.
• W2027748124 type Work @default.
• W2027748124 sameAs 2027748124 @default.
• W2027748124 citedByCount "3" @default.
• W2027748124 countsByYear W20277481242015 @default.
• W2027748124 crossrefType "journal-article" @default.
• W2027748124 hasAuthorship W2027748124A5019635887 @default.
• W2027748124 hasBestOaLocation W20277481241 @default.
• W2027748124 hasConcept C121608353 @default.
• W2027748124 hasConcept C126322002 @default.
• W2027748124 hasConcept C126838900 @default.
• W2027748124 hasConcept C142724271 @default.
• W2027748124 hasConcept C143998085 @default.
• W2027748124 hasConcept C2776256026 @default.
• W2027748124 hasConcept C2777714996 @default.
• W2027748124 hasConcept C2781182431 @default.
• W2027748124 hasConcept C71924100 @default.
• W2027748124 hasConceptScore W2027748124C121608353 @default.
• W2027748124 hasConceptScore W2027748124C126322002 @default.
• W2027748124 hasConceptScore W2027748124C126838900 @default.
• W2027748124 hasConceptScore W2027748124C142724271 @default.
• W2027748124 hasConceptScore W2027748124C143998085 @default.
• W2027748124 hasConceptScore W2027748124C2776256026 @default.
• W2027748124 hasConceptScore W2027748124C2777714996 @default.
• W2027748124 hasConceptScore W2027748124C2781182431 @default.
• W2027748124 hasConceptScore W2027748124C71924100 @default.
• W2027748124 hasLocation W20277481241 @default.
• W2027748124 hasLocation W20277481242 @default.
• W2027748124 hasOpenAccess W2027748124 @default.
• W2027748124 hasPrimaryLocation W20277481241 @default.
• W2027748124 hasRelatedWork W1969686908 @default.
• W2027748124 hasRelatedWork W1974875585 @default.
• W2027748124 hasRelatedWork W2020416181 @default.
• W2027748124 hasRelatedWork W2043288537 @default.
• W2027748124 hasRelatedWork W2047448215 @default.
• W2027748124 hasRelatedWork W2059680335 @default.
• W2027748124 hasRelatedWork W2061985697 @default.
• W2027748124 hasRelatedWork W2080073877 @default.
• W2027748124 hasRelatedWork W2102322509 @default.
• W2027748124 hasRelatedWork W2124254751 @default.
• W2027748124 hasRelatedWork W2149740591 @default.
• W2027748124 hasRelatedWork W2171744168 @default.
• W2027748124 hasRelatedWork W2325335085 @default.
• W2027748124 hasRelatedWork W23308814 @default.
• W2027748124 hasRelatedWork W2395694487 @default.
• W2027748124 hasRelatedWork W2412067274 @default.
• W2027748124 hasRelatedWork W2789867747 @default.
• W2027748124 hasRelatedWork W2883289134 @default.
• W2027748124 hasRelatedWork W57161562 @default.
• W2027748124 hasRelatedWork W2059296935 @default.
• W2027748124 isParatext "false" @default.
• W2027748124 isRetracted "false" @default.
• W2027748124 magId "2027748124" @default.
• W2027748124 workType "article" @default.