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- W2027753003 abstract "Guanine riboswitches are structural elements in the 5′- untranslated region of certain mRNAs. These RNA receptors specifically bind guanine and other closely related purines to regulate gene expression. While the basis of ligand-binding and molecular discrimination has been studied to atomic details, the associated structural rearrangements upon ligand-binding are poorly understood. Using a high resolution optical-tweezers that can measure forces at +/− 0.15 pN, distances at 1 nm accuracy with temporal resolution of sub-milliseconds (< 0.25 msec), we followed the structural rearrangements that follows immediately upon guanine-binding at < 1 sec. Our results from the equilibrium sampling and the mutational analysis provide mechanistic insights into the folding of kissing loop interactions that are crucial for the compaction of the riboswitch core leading to the receptor conformation." @default.
- W2027753003 created "2016-06-24" @default.
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- W2027753003 date "2015-01-01" @default.
- W2027753003 modified "2023-09-29" @default.
- W2027753003 title "Single-Molecule Studies of Kissing Loop Interactions in Guanine Riboswitch" @default.
- W2027753003 doi "https://doi.org/10.1016/j.bpj.2014.11.175" @default.
- W2027753003 hasPublicationYear "2015" @default.
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