FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027753376> ?p ?o ?g. }

• W2027753376 endingPage "354" @default.
• W2027753376 startingPage "354" @default.
• W2027753376 abstract "There exists a growing interest in intra-operative radiation therapy as a treatment modality for large bowel cancer. In a previous experimental study we showed that high-dose intra-operative irradiation delays the healing of colonic anastomoses. However, the contribution of proteases is unknown. In the present study, the gelatinolytic and collagenolytic activity in the healing anastomoses is investigated. After a resection of a 1-cm length of colon (uninjured colon), the rats were irradiated with a single dose of 25 Gy, either to the proximal limb, referred to as the proximal group, or to both proximal and distal limbs of the bowel, referred to as the combined group, before anastomotic construction. Both groups were compared to a control group with anastomoses which were sham-irradiated. The animals were killed 1, 3 or 7 days after operation. The gelatinolytic activity in uninjured and anastomotic tissue was quantified by gelatin zymography and the collagenolytic activity by an assay using a fibrillar rat collagen substrate. Compared with resected uninjured colon, most of the gelatinolytic activities were markedly increased in anastomotic tissue of all groups during the first postoperative week, and new additional activities were detected. The additional metalloproteinases (the 95-kDa family) of both irradiated groups were significantly elevated compared to the anastomoses of the sham-irradiated control group at 7 days after operation. In anastomotic tissue of all groups, the collagenolytic activity of the tissue was also significantly increased at 1 and 3 days after construction with respect to the resected, uninjured colon. After 7 days this effect had disappeared for the sham-irradiated anastomoses, but the activity in the anastomoses in both the proximal and combined groups remained significantly elevated. The findings provide evidence that intra-operative irradiation prolongs the presence of elevated gelatinolytic and collagenolytic activities in colon anastomoses. It may contribute to a reduced or delayed accumulation of collagen and other matrix proteins that supply anastomotic strength." @default.
• W2027753376 created "2016-06-24" @default.
• W2027753376 creator A5029598979 @default.
• W2027753376 creator A5048660941 @default.
• W2027753376 creator A5049689151 @default.
• W2027753376 creator A5062019573 @default.
• W2027753376 creator A5080080048 @default.
• W2027753376 date "1997-03-01" @default.
• W2027753376 modified "2023-10-16" @default.
• W2027753376 title "Intra-Operative Irradiation Prolongs the Presence of Matrix Metalloproteinase Activity in Large Bowel Anastomoses of the Rat" @default.
• W2027753376 cites W1546619202 @default.
• W2027753376 cites W1585596487 @default.
• W2027753376 cites W1741255825 @default.
• W2027753376 cites W1977918153 @default.
• W2027753376 cites W1989499593 @default.
• W2027753376 cites W2022302688 @default.
• W2027753376 cites W2056694867 @default.
• W2027753376 cites W2057055923 @default.
• W2027753376 cites W2058815673 @default.
• W2027753376 cites W2067625724 @default.
• W2027753376 cites W2088497174 @default.
• W2027753376 cites W2090117970 @default.
• W2027753376 cites W2095498651 @default.
• W2027753376 cites W2100837269 @default.
• W2027753376 cites W2109658199 @default.
• W2027753376 cites W2125077605 @default.
• W2027753376 cites W2151170471 @default.
• W2027753376 cites W2411775715 @default.
• W2027753376 cites W2887323685 @default.
• W2027753376 doi "https://doi.org/10.2307/3579344" @default.
• W2027753376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9052683" @default.
• W2027753376 hasPublicationYear "1997" @default.
• W2027753376 type Work @default.
• W2027753376 sameAs 2027753376 @default.
• W2027753376 citedByCount "18" @default.
• W2027753376 countsByYear W20277533762014 @default.
• W2027753376 countsByYear W20277533762018 @default.
• W2027753376 countsByYear W20277533762020 @default.
• W2027753376 crossrefType "journal-article" @default.
• W2027753376 hasAuthorship W2027753376A5029598979 @default.
• W2027753376 hasAuthorship W2027753376A5048660941 @default.
• W2027753376 hasAuthorship W2027753376A5049689151 @default.
• W2027753376 hasAuthorship W2027753376A5062019573 @default.
• W2027753376 hasAuthorship W2027753376A5080080048 @default.
• W2027753376 hasConcept C109523444 @default.
• W2027753376 hasConcept C126322002 @default.
• W2027753376 hasConcept C126894567 @default.
• W2027753376 hasConcept C141071460 @default.
• W2027753376 hasConcept C177430391 @default.
• W2027753376 hasConcept C181199279 @default.
• W2027753376 hasConcept C185592680 @default.
• W2027753376 hasConcept C2776232661 @default.
• W2027753376 hasConcept C2778394429 @default.
• W2027753376 hasConcept C2778823387 @default.
• W2027753376 hasConcept C2780269544 @default.
• W2027753376 hasConcept C55493867 @default.
• W2027753376 hasConcept C71924100 @default.
• W2027753376 hasConcept C8443397 @default.
• W2027753376 hasConceptScore W2027753376C109523444 @default.
• W2027753376 hasConceptScore W2027753376C126322002 @default.
• W2027753376 hasConceptScore W2027753376C126894567 @default.
• W2027753376 hasConceptScore W2027753376C141071460 @default.
• W2027753376 hasConceptScore W2027753376C177430391 @default.
• W2027753376 hasConceptScore W2027753376C181199279 @default.
• W2027753376 hasConceptScore W2027753376C185592680 @default.
• W2027753376 hasConceptScore W2027753376C2776232661 @default.
• W2027753376 hasConceptScore W2027753376C2778394429 @default.
• W2027753376 hasConceptScore W2027753376C2778823387 @default.
• W2027753376 hasConceptScore W2027753376C2780269544 @default.
• W2027753376 hasConceptScore W2027753376C55493867 @default.
• W2027753376 hasConceptScore W2027753376C71924100 @default.
• W2027753376 hasConceptScore W2027753376C8443397 @default.
• W2027753376 hasIssue "3" @default.
• W2027753376 hasLocation W20277533761 @default.
• W2027753376 hasLocation W20277533762 @default.
• W2027753376 hasOpenAccess W2027753376 @default.
• W2027753376 hasPrimaryLocation W20277533761 @default.
• W2027753376 hasRelatedWork W1986457921 @default.
• W2027753376 hasRelatedWork W1986890976 @default.
• W2027753376 hasRelatedWork W2017233373 @default.
• W2027753376 hasRelatedWork W2044610509 @default.
• W2027753376 hasRelatedWork W2045399305 @default.
• W2027753376 hasRelatedWork W2088497174 @default.
• W2027753376 hasRelatedWork W2106319388 @default.
• W2027753376 hasRelatedWork W2109973285 @default.
• W2027753376 hasRelatedWork W2411082965 @default.
• W2027753376 hasRelatedWork W2422381800 @default.
• W2027753376 hasVolume "147" @default.
• W2027753376 isParatext "false" @default.
• W2027753376 isRetracted "false" @default.
• W2027753376 magId "2027753376" @default.
• W2027753376 workType "article" @default.