FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027755763> ?p ?o ?g. }

• W2027755763 endingPage "844" @default.
• W2027755763 startingPage "837" @default.
• W2027755763 abstract "Abstract Context: Abnormal plasma nonesterified fatty acid (NEFA) metabolism may play a role in the development of type 2 diabetes. Objectives: Our objectives were to demonstrate whether there is a defect in insulin-mediated suppression of plasma NEFA appearance (RaNEFA) and oxidation (OxNEFA) during enhanced intravascular triacylglycerol lipolysis early in the natural history of type 2 diabetes, and if so, to determine whether other mechanisms than reduced insulin-mediated suppression of intracellular lipolysis are involved. Design: These are cross-sectional studies. Setting: The studies were performed at an academic clinical research center. Participants: Nine healthy subjects with both parents with type 2 diabetes (FH+) and nine healthy subjects with no first-degree relatives with type 2 diabetes (FH−) with similar anthropometric features were included in the studies. Interventions: Pancreatic clamps and iv infusion of stable isotopic tracers ([1,1,2,3,3-2H5]-glycerol and [U-13C]-palmitate or [1,2-13C]-acetate) were performed while intravascular triacylglycerol lipolysis was simultaneously clamped by iv infusion of heparin plus Intralipid at low (fasting) and high insulin levels. Oral nicotinic acid (NA) was used to inhibit intracellular lipolysis. Main Outcome Measures: RaNEFA and OxNEFA were determined. Results: During heparin plus Intralipid infusion at high plasma insulin levels, and despite similar intravascular lipolytic rates, FH+ had higher RaNEFA and OxNEFA than FH− (RaNEFA: 17.4 ± 6.3 vs. 9.2 ± 4.2; OxNEFA: 4.5 ± 1.8 vs. 2.3 ± 1.5 μmol/kg lean body mass/min), independent of NA intake, gender, age, and body composition. In the presence of NA, insulin-mediated suppression of RaNEFA was still observed in FH−, but not in FH+. Conclusions: Increased RaNEFA and OxNEFA during intravascular lipolysis at high insulin levels occur early in the natural history of type 2 diabetes." @default.
• W2027755763 created "2016-06-24" @default.
• W2027755763 creator A5021200148 @default.
• W2027755763 creator A5029941147 @default.
• W2027755763 creator A5038741757 @default.
• W2027755763 creator A5043146616 @default.
• W2027755763 creator A5049861022 @default.
• W2027755763 creator A5060031678 @default.
• W2027755763 creator A5071022757 @default.
• W2027755763 creator A5085813678 @default.
• W2027755763 creator A5088681787 @default.
• W2027755763 creator A5090608934 @default.
• W2027755763 date "2008-03-01" @default.
• W2027755763 modified "2023-10-15" @default.
• W2027755763 title "Impaired Plasma Nonesterified Fatty Acid Tolerance Is an Early Defect in the Natural History of Type 2 Diabetes" @default.
• W2027755763 cites W1824808911 @default.
• W2027755763 cites W1972230452 @default.
• W2027755763 cites W1990630374 @default.
• W2027755763 cites W1999881074 @default.
• W2027755763 cites W2003950656 @default.
• W2027755763 cites W2004120544 @default.
• W2027755763 cites W2014823116 @default.
• W2027755763 cites W2022294953 @default.
• W2027755763 cites W2023346162 @default.
• W2027755763 cites W2027670788 @default.
• W2027755763 cites W2035231077 @default.
• W2027755763 cites W2042637405 @default.
• W2027755763 cites W2051313176 @default.
• W2027755763 cites W2056054976 @default.
• W2027755763 cites W2066736958 @default.
• W2027755763 cites W2081546325 @default.
• W2027755763 cites W2090600090 @default.
• W2027755763 cites W2100625395 @default.
• W2027755763 cites W2104680343 @default.
• W2027755763 cites W2112236821 @default.
• W2027755763 cites W2112375566 @default.
• W2027755763 cites W2122984833 @default.
• W2027755763 cites W2123261567 @default.
• W2027755763 cites W2123521914 @default.
• W2027755763 cites W2127301790 @default.
• W2027755763 cites W2128189374 @default.
• W2027755763 cites W2131501155 @default.
• W2027755763 cites W2138509626 @default.
• W2027755763 cites W2141377753 @default.
• W2027755763 cites W2148562280 @default.
• W2027755763 cites W2152386173 @default.
• W2027755763 cites W2154606744 @default.
• W2027755763 cites W2156690149 @default.
• W2027755763 cites W2159896083 @default.
• W2027755763 cites W2181817569 @default.
• W2027755763 cites W2422651944 @default.
• W2027755763 cites W4205718468 @default.
• W2027755763 doi "https://doi.org/10.1210/jc.2007-1670" @default.
• W2027755763 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2266943" @default.
• W2027755763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18182453" @default.
• W2027755763 hasPublicationYear "2008" @default.
• W2027755763 type Work @default.
• W2027755763 sameAs 2027755763 @default.
• W2027755763 citedByCount "51" @default.
• W2027755763 countsByYear W20277557632012 @default.
• W2027755763 countsByYear W20277557632013 @default.
• W2027755763 countsByYear W20277557632014 @default.
• W2027755763 countsByYear W20277557632015 @default.
• W2027755763 countsByYear W20277557632016 @default.
• W2027755763 countsByYear W20277557632017 @default.
• W2027755763 countsByYear W20277557632018 @default.
• W2027755763 countsByYear W20277557632020 @default.
• W2027755763 countsByYear W20277557632021 @default.
• W2027755763 countsByYear W20277557632022 @default.
• W2027755763 countsByYear W20277557632023 @default.
• W2027755763 crossrefType "journal-article" @default.
• W2027755763 hasAuthorship W2027755763A5021200148 @default.
• W2027755763 hasAuthorship W2027755763A5029941147 @default.
• W2027755763 hasAuthorship W2027755763A5038741757 @default.
• W2027755763 hasAuthorship W2027755763A5043146616 @default.
• W2027755763 hasAuthorship W2027755763A5049861022 @default.
• W2027755763 hasAuthorship W2027755763A5060031678 @default.
• W2027755763 hasAuthorship W2027755763A5071022757 @default.
• W2027755763 hasAuthorship W2027755763A5085813678 @default.
• W2027755763 hasAuthorship W2027755763A5088681787 @default.
• W2027755763 hasAuthorship W2027755763A5090608934 @default.
• W2027755763 hasBestOaLocation W20277557632 @default.
• W2027755763 hasConcept C126322002 @default.
• W2027755763 hasConcept C134018914 @default.
• W2027755763 hasConcept C140985366 @default.
• W2027755763 hasConcept C151730666 @default.
• W2027755763 hasConcept C171089720 @default.
• W2027755763 hasConcept C185592680 @default.
• W2027755763 hasConcept C2777180221 @default.
• W2027755763 hasConcept C2777391703 @default.
• W2027755763 hasConcept C2778808658 @default.
• W2027755763 hasConcept C2779306644 @default.
• W2027755763 hasConcept C2779343474 @default.
• W2027755763 hasConcept C2779772378 @default.
• W2027755763 hasConcept C2780352109 @default.
• W2027755763 hasConcept C543025807 @default.
• W2027755763 hasConcept C55493867 @default.
• W2027755763 hasConcept C555293320 @default.

• next