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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027760571> ?p ?o ?g. }

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• W2027760571 abstract "Guided by structure-based drug design, modification of the 1,4-benzodiazepin-2,5-dione lead compound 1 resulted in the discovery of 19, a potent and orally bioavailable antagonist of the HDM2-p53 protein–protein interaction (FP IC50 = 0.7 μM, F ≈ 100%)." @default.
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• W2027760571 date "2006-06-01" @default.
• W2027760571 modified "2023-09-27" @default.
• W2027760571 title "Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein–protein interaction through structure-based drug design" @default.
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• W2027760571 doi "https://doi.org/10.1016/j.bmcl.2006.03.055" @default.
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