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- W2027761572 abstract "The cysteine-dependent aspartate-specific protease 8 (CASP8) is a key enzyme in the apoptosis and genetic polymorphisms in this gene have been reported to affect the gene expression and its enzymatic activity. A six-nucleotide insertion-deletion polymorphism (-652 6N ins/del, rs3834129) in the CASP8 promoter has been shown to be associated with susceptibility to multiple cancers in the Asian populations. Here we report results of genotyping the CASP8 ins/del polymorphism in non-small cell lung cancer (NSCLC) cases and controls from Norway, all of which are of Caucasian origin. The overall odds ratio for NSCLC was 1.40 (95% CI, 0.95-2.06). When subjects were grouped according to gender, males carrying del/del genotype had an increased odds ratio for developing NSCLC with an OR of 1.61 (95% CI, 1.02-2.53, P=0.039). Somatic mutations of the TP53 gene in tumors were also analyzed and the results showed no interaction between alterations in TP53 and the CASP8 polymorphism. These results contradict a protective effect of this polymorphism on lung cancer as it has been reported in the Asian populations. The results are discussed in relation to population and exposure specific effects of this polymorphism." @default.
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- W2027761572 date "2010-04-01" @default.
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- W2027761572 title "The CASPASE-8 Insertion/Deletion Polymorphism and Risk of Non-small Cell Lung Cancer" @default.
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- W2027761572 doi "https://doi.org/10.5099/aj100200121" @default.
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