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- W2027771429 abstract "Seventeen N,N′-benzene-1,3-dimethane and nine N,N′,N″-benzene-1,3,5-trimethane derivatives with fluorescent properties have been synthesized. Three of them show antiplatelet activities (inducer collagen, IC50 Born-test) in concentrations < 10 μmol/L. They are suitable for interaction studies with biological macromolecules and synthetical and biological membranes. Structure activity relationships demonstrate that heteropolycyclic fluorophores i.e. quinoline, dibenzofurane, or carbazole are favorable substituents for this purpose. Antiaggregatorische und anticoagulante Eigenschaften von Oligoaminen, 18. Mitt.: Fluoreszierende Oligoamine, Teil B: Fluorophore in der Molekülperipherie Siebzehn N,N″-Benzol-1,3-dimethanamine und neun N,N′,N″-Benzol-1,3,5-trimethanamine mit fluoreszierenden Eigenschaften wurden dargestellt. Hiervon hemmten drei Verbindungen die Thrombocytenaggregation in Konzentration < 10 μmol/L halbmaximal (Born-Test, Aggregationsauslöser Collagen). Sie sind damit für Interaktionsstudien an biologischen Makromolekülen sowie an synthetischen und natürlichen Membranen geeignet. Die Untersuchungen ergaben, daß mehrkernige Heterocyclen wie Chinolin, Dibenzofuran oder Carbazol besonders geeignete fluorophore Substituenten sind." @default.
- W2027771429 created "2016-06-24" @default.
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- W2027771429 date "1994-01-01" @default.
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- W2027771429 title "Platelet Aggregation Inhibiting and Anticoagulant Effects of Oligoamines, XVIII: Oligoamines with Fluorescent Properties, Part B: Fluorophores in the Molecular Periphery" @default.
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- W2027771429 doi "https://doi.org/10.1002/ardp.19943270611" @default.
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