Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027776872> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2027776872 abstract "Summary Therapeutic principles in the conventional medical treatment of myocardial ischemia in clinically stable coronary artery disease e.g. nitrates, beta-blockers, and calcium antagonists are mainly guided by a reduction of cardiac work load, hence a reduction of cardiac pre- and afterload, as well as by a decrease of vasomotor tone in epicardial conductance vessels and changes of myocardial metabolism. Even though they enhance exercise-limited myocardial perfusion and improve the quality of life, they influence the actual pathogenesis of coronary atherosclerosis only marginally, probably a major reason for the lacking therapeutic effect of these agents on major cardiovascular events. In contrast, antithrombotic and lipid lowering therapy not only reduce acute events like cardiovascular death, myocardial infarction, and unstable angina but can also contribute to a preservation and an enhancement of coronary blood flow in the chronic state of the disease. It has been shown that anti-platelet agents may reduce new coronary lesion formation and probably have an impact on actual regression of atherosclerotic carotid plaques in a higher dosage, as presently used. Anticoagulants like low-molecular weight heparin have been shown to improve subjective and objective signs of exercise-induced myocardial ischemia. In addition to an enhancement of collateral function, antithrombotic effects on subclinical coronary thrombus formation seem likely. Long-term intermittent urokinase therapy, which has been developed for patients with refractory angina pectoris in end-stage coronary artery disease, reduces myocardial ischemia by an improvement of rheological blood properties mediated by a decrease of fibrinogen. In addition, thrombolytic properties of this regimen as well as actual plaque regression may contribute substantially to clinical effectiveness." @default.
- W2027776872 created "2016-06-24" @default.
- W2027776872 creator A5001160860 @default.
- W2027776872 creator A5018774735 @default.
- W2027776872 creator A5047719615 @default.
- W2027776872 creator A5080492527 @default.
- W2027776872 date "1997-04-01" @default.
- W2027776872 modified "2023-09-27" @default.
- W2027776872 title "Antithrombotic treatment for the preservation and enhancement of myocardial perfusion in chronic coronary artery disease" @default.
- W2027776872 cites W1961781761 @default.
- W2027776872 cites W1987839981 @default.
- W2027776872 cites W1997448265 @default.
- W2027776872 cites W2000839693 @default.
- W2027776872 cites W2009784171 @default.
- W2027776872 cites W2010545674 @default.
- W2027776872 cites W2013418886 @default.
- W2027776872 cites W2018153873 @default.
- W2027776872 cites W2027827558 @default.
- W2027776872 cites W2028249918 @default.
- W2027776872 cites W2038782636 @default.
- W2027776872 cites W2081013776 @default.
- W2027776872 cites W2089900480 @default.
- W2027776872 cites W2091767169 @default.
- W2027776872 cites W2139505048 @default.
- W2027776872 cites W2162766410 @default.
- W2027776872 cites W2401461220 @default.
- W2027776872 cites W2406670960 @default.
- W2027776872 cites W3112270648 @default.
- W2027776872 cites W629258600 @default.
- W2027776872 cites W1512144932 @default.
- W2027776872 cites W2019463117 @default.
- W2027776872 cites W2073346843 @default.
- W2027776872 cites W2119899834 @default.
- W2027776872 doi "https://doi.org/10.1016/s0268-9499(97)80035-5" @default.
- W2027776872 hasPublicationYear "1997" @default.
- W2027776872 type Work @default.
- W2027776872 sameAs 2027776872 @default.
- W2027776872 citedByCount "1" @default.
- W2027776872 crossrefType "journal-article" @default.
- W2027776872 hasAuthorship W2027776872A5001160860 @default.
- W2027776872 hasAuthorship W2027776872A5018774735 @default.
- W2027776872 hasAuthorship W2027776872A5047719615 @default.
- W2027776872 hasAuthorship W2027776872A5080492527 @default.
- W2027776872 hasConcept C126322002 @default.
- W2027776872 hasConcept C164705383 @default.
- W2027776872 hasConcept C2777015399 @default.
- W2027776872 hasConcept C2778213512 @default.
- W2027776872 hasConcept C2778425758 @default.
- W2027776872 hasConcept C2781362458 @default.
- W2027776872 hasConcept C500558357 @default.
- W2027776872 hasConcept C541997718 @default.
- W2027776872 hasConcept C71924100 @default.
- W2027776872 hasConceptScore W2027776872C126322002 @default.
- W2027776872 hasConceptScore W2027776872C164705383 @default.
- W2027776872 hasConceptScore W2027776872C2777015399 @default.
- W2027776872 hasConceptScore W2027776872C2778213512 @default.
- W2027776872 hasConceptScore W2027776872C2778425758 @default.
- W2027776872 hasConceptScore W2027776872C2781362458 @default.
- W2027776872 hasConceptScore W2027776872C500558357 @default.
- W2027776872 hasConceptScore W2027776872C541997718 @default.
- W2027776872 hasConceptScore W2027776872C71924100 @default.
- W2027776872 hasLocation W20277768721 @default.
- W2027776872 hasOpenAccess W2027776872 @default.
- W2027776872 hasPrimaryLocation W20277768721 @default.
- W2027776872 hasRelatedWork W1535922880 @default.
- W2027776872 hasRelatedWork W1985068723 @default.
- W2027776872 hasRelatedWork W2017415062 @default.
- W2027776872 hasRelatedWork W2027415925 @default.
- W2027776872 hasRelatedWork W2074660570 @default.
- W2027776872 hasRelatedWork W2076938668 @default.
- W2027776872 hasRelatedWork W2076958602 @default.
- W2027776872 hasRelatedWork W2080375596 @default.
- W2027776872 hasRelatedWork W2162163033 @default.
- W2027776872 hasRelatedWork W2219251076 @default.
- W2027776872 hasRelatedWork W2259202595 @default.
- W2027776872 hasRelatedWork W2397122059 @default.
- W2027776872 hasRelatedWork W2403088920 @default.
- W2027776872 hasRelatedWork W2415743100 @default.
- W2027776872 hasRelatedWork W2415941590 @default.
- W2027776872 hasRelatedWork W2416369272 @default.
- W2027776872 hasRelatedWork W3189085093 @default.
- W2027776872 hasRelatedWork W348357617 @default.
- W2027776872 hasRelatedWork W42679069 @default.
- W2027776872 hasRelatedWork W587608438 @default.
- W2027776872 isParatext "false" @default.
- W2027776872 isRetracted "false" @default.
- W2027776872 magId "2027776872" @default.
- W2027776872 workType "article" @default.