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- W2027779917 endingPage "1006" @default.
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- W2027779917 abstract "Significance: Mitochondrial ion channels/transporters and the electron transport chain (ETC) serve as key sensors and regulators for cellular redox signaling, the production of reactive oxygen species (ROS) and nitrogen species (RNS) in mitochondria, and balancing cell survival and death. Although the functional and pharmacological characteristics of mitochondrial ion transport mechanisms have been extensively studied for several decades, the majority of the molecular identities that are responsible for these channels/transporters have remained a mystery until very recently. Recent Advances: Recent breakthrough studies uncovered the molecular identities of the diverse array of major mitochondrial ion channels/transporters, including the mitochondrial Ca2+ uniporter pore, mitochondrial permeability transition pore, and mitochondrial ATP-sensitive K+ channel. This new information enables us to form detailed molecular and functional characterizations of mitochondrial ion channels/transporters and their roles in mitochondrial redox signaling. Critical Issues: Redox-mediated post-translational modifications of mitochondrial ion channels/transporters and ETC serve as key mechanisms for the spatiotemporal control of mitochondrial ROS/RNS generation. Future Directions: Identification of detailed molecular mechanisms for redox-mediated regulation of mitochondrial ion channels will enable us to find novel therapeutic targets for many diseases that are associated with cellular redox signaling and mitochondrial ion channels/transporters. Antioxid. Redox Signal. 21, 987–1006." @default.
- W2027779917 created "2016-06-24" @default.
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- W2027779917 creator A5084620328 @default.
- W2027779917 date "2014-08-20" @default.
- W2027779917 modified "2023-10-09" @default.
- W2027779917 title "Mitochondrial Ion Channels/Transporters as Sensors and Regulators of Cellular Redox Signaling" @default.
- W2027779917 cites W1497458285 @default.
- W2027779917 cites W1500939659 @default.
- W2027779917 cites W1559795048 @default.
- W2027779917 cites W1563772752 @default.
- W2027779917 cites W1575028275 @default.
- W2027779917 cites W1601281079 @default.
- W2027779917 cites W1607531254 @default.
- W2027779917 cites W1821824803 @default.
- W2027779917 cites W1850791929 @default.
- W2027779917 cites W193759809 @default.
- W2027779917 cites W1940436875 @default.
- W2027779917 cites W1964483580 @default.
- W2027779917 cites W1967727543 @default.
- W2027779917 cites W1969554005 @default.
- W2027779917 cites W1969940696 @default.
- W2027779917 cites W1970554352 @default.
- W2027779917 cites W1971363580 @default.
- W2027779917 cites W1972718661 @default.
- W2027779917 cites W1974560134 @default.
- W2027779917 cites W1975090760 @default.
- W2027779917 cites W1975268362 @default.
- W2027779917 cites W1976708727 @default.
- W2027779917 cites W1978042419 @default.
- W2027779917 cites W1978631786 @default.
- W2027779917 cites W1980959570 @default.
- W2027779917 cites W1982662455 @default.
- W2027779917 cites W1983521522 @default.
- W2027779917 cites W1984661543 @default.
- W2027779917 cites W1986213783 @default.
- W2027779917 cites W1986760146 @default.
- W2027779917 cites W1988751970 @default.
- W2027779917 cites W1988942619 @default.
- W2027779917 cites W1990299268 @default.
- W2027779917 cites W1991055482 @default.
- W2027779917 cites W1991436274 @default.
- W2027779917 cites W1992718978 @default.
- W2027779917 cites W1993039541 @default.
- W2027779917 cites W1993418135 @default.
- W2027779917 cites W1993851979 @default.
- W2027779917 cites W1993969966 @default.
- W2027779917 cites W1994270731 @default.
- W2027779917 cites W1994442108 @default.
- W2027779917 cites W1995168386 @default.
- W2027779917 cites W1996439971 @default.
- W2027779917 cites W1996738096 @default.
- W2027779917 cites W1997759034 @default.
- W2027779917 cites W2000075945 @default.
- W2027779917 cites W2002475003 @default.
- W2027779917 cites W2002791298 @default.
- W2027779917 cites W2004351789 @default.
- W2027779917 cites W2005248412 @default.
- W2027779917 cites W2005573382 @default.
- W2027779917 cites W2005861308 @default.
- W2027779917 cites W2005880659 @default.
- W2027779917 cites W2007737411 @default.
- W2027779917 cites W2008613466 @default.
- W2027779917 cites W2008624998 @default.
- W2027779917 cites W2009461852 @default.
- W2027779917 cites W2010572143 @default.
- W2027779917 cites W2012868446 @default.
- W2027779917 cites W2015221597 @default.
- W2027779917 cites W2015225154 @default.
- W2027779917 cites W2016894809 @default.
- W2027779917 cites W2016936426 @default.
- W2027779917 cites W2017275974 @default.
- W2027779917 cites W2017567300 @default.
- W2027779917 cites W2018089300 @default.
- W2027779917 cites W2018207304 @default.
- W2027779917 cites W2021639791 @default.
- W2027779917 cites W2022101585 @default.
- W2027779917 cites W2024870847 @default.
- W2027779917 cites W2026071204 @default.
- W2027779917 cites W2027393096 @default.
- W2027779917 cites W2029038770 @default.
- W2027779917 cites W2030099878 @default.
- W2027779917 cites W2030142800 @default.
- W2027779917 cites W2030496404 @default.
- W2027779917 cites W2031615792 @default.
- W2027779917 cites W2033107215 @default.
- W2027779917 cites W2035968737 @default.
- W2027779917 cites W2036697787 @default.
- W2027779917 cites W2037676584 @default.
- W2027779917 cites W2037864697 @default.
- W2027779917 cites W2038468721 @default.
- W2027779917 cites W2041000089 @default.
- W2027779917 cites W2042959152 @default.
- W2027779917 cites W2043364216 @default.
- W2027779917 cites W2045408001 @default.