FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027785028> ?p ?o ?g. }

• W2027785028 endingPage "745" @default.
• W2027785028 startingPage "734" @default.
• W2027785028 abstract "UVB radiation is the major carcinogen responsible for skin carcinogenesis, thus elucidation of the molecular pathways altered in skin in response to UVB would reveal novel targets for therapeutic intervention. It is well established that UVB leads to upregulation of cyclooxygenase 2 (COX-2) in the skin which contributes to skin carcinogenesis. Overexpression of COX-2 has been shown to promote colon cancer cell growth through β-catenin signaling, however, little is known about the connection between UVB, COX-2, and β-catenin in the skin. In the present study, we have identified a novel pathway in which UVB induces β-catenin signaling in keratinocytes, which is modulated by COX-2 expression. Exposure of the mouse 308 keratinocyte cell line (308 cells) and primary normal human epidermal keratinocytes (NHEKs) to UVB resulted in increased protein levels of both N-terminally unphosphorylated and total β-catenin. In addition, we found that UVB-enhanced β-catenin-dependent TOPflash reporter activity and expression of a downstream β-catenin target gene. We demonstrated that UVB-induced β-catenin signaling is modulated by COX-2, as treatment of keratinocytes with the specific COX-2 inhibitor NS398 blocked UVB induction of β-catenin. Additionally, β-catenin target gene expression was reduced in UVB-treated COX-2 knockout (KO) MEFs compared to wild-type (WT) MEFs. Furthermore, epidermis from UVB-exposed SKH-1 mice exhibited increased N-terminally unphosphorylated and total β-catenin protein levels and increased staining for total β-catenin, and both responses were reduced in COX-2 heterozygous mice. Taken together, these results suggest a novel pathway in which UVB induces β-catenin signaling in keratinocytes which is enhanced by COX-2 expression." @default.
• W2027785028 created "2016-06-24" @default.
• W2027785028 creator A5003077528 @default.
• W2027785028 creator A5033888217 @default.
• W2027785028 creator A5055806462 @default.
• W2027785028 creator A5056585843 @default.
• W2027785028 creator A5060622890 @default.
• W2027785028 creator A5066656229 @default.
• W2027785028 creator A5070414768 @default.
• W2027785028 date "2011-08-18" @default.
• W2027785028 modified "2023-09-27" @default.
• W2027785028 title "UVB radiation-induced β-catenin signaling is enhanced by COX-2 expression in keratinocytes" @default.
• W2027785028 cites W1541209562 @default.
• W2027785028 cites W1545043863 @default.
• W2027785028 cites W1927414006 @default.
• W2027785028 cites W1964060678 @default.
• W2027785028 cites W1967629365 @default.
• W2027785028 cites W1967803088 @default.
• W2027785028 cites W1989810757 @default.
• W2027785028 cites W2003006686 @default.
• W2027785028 cites W2010230445 @default.
• W2027785028 cites W2011463708 @default.
• W2027785028 cites W2011912935 @default.
• W2027785028 cites W2016266198 @default.
• W2027785028 cites W2020642328 @default.
• W2027785028 cites W2029972069 @default.
• W2027785028 cites W2036041106 @default.
• W2027785028 cites W2040040765 @default.
• W2027785028 cites W2040528315 @default.
• W2027785028 cites W2046464769 @default.
• W2027785028 cites W2060587063 @default.
• W2027785028 cites W2061879991 @default.
• W2027785028 cites W2062096656 @default.
• W2027785028 cites W2072403302 @default.
• W2027785028 cites W2074563859 @default.
• W2027785028 cites W2079285334 @default.
• W2027785028 cites W2098426789 @default.
• W2027785028 cites W2100130506 @default.
• W2027785028 cites W2100735085 @default.
• W2027785028 cites W2101249156 @default.
• W2027785028 cites W2102512718 @default.
• W2027785028 cites W2103797279 @default.
• W2027785028 cites W2109328185 @default.
• W2027785028 cites W2110212421 @default.
• W2027785028 cites W2124921409 @default.
• W2027785028 cites W2135426075 @default.
• W2027785028 cites W2145125577 @default.
• W2027785028 cites W2147471897 @default.
• W2027785028 cites W2148558073 @default.
• W2027785028 cites W2152771783 @default.
• W2027785028 cites W2170888506 @default.
• W2027785028 cites W75138201 @default.
• W2027785028 doi "https://doi.org/10.1002/mc.20840" @default.
• W2027785028 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4440547" @default.
• W2027785028 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21853475" @default.
• W2027785028 hasPublicationYear "2011" @default.
• W2027785028 type Work @default.
• W2027785028 sameAs 2027785028 @default.
• W2027785028 citedByCount "19" @default.
• W2027785028 countsByYear W20277850282013 @default.
• W2027785028 countsByYear W20277850282014 @default.
• W2027785028 countsByYear W20277850282015 @default.
• W2027785028 countsByYear W20277850282017 @default.
• W2027785028 countsByYear W20277850282018 @default.
• W2027785028 countsByYear W20277850282021 @default.
• W2027785028 countsByYear W20277850282022 @default.
• W2027785028 countsByYear W20277850282023 @default.
• W2027785028 crossrefType "journal-article" @default.
• W2027785028 hasAuthorship W2027785028A5003077528 @default.
• W2027785028 hasAuthorship W2027785028A5033888217 @default.
• W2027785028 hasAuthorship W2027785028A5055806462 @default.
• W2027785028 hasAuthorship W2027785028A5056585843 @default.
• W2027785028 hasAuthorship W2027785028A5060622890 @default.
• W2027785028 hasAuthorship W2027785028A5066656229 @default.
• W2027785028 hasAuthorship W2027785028A5070414768 @default.
• W2027785028 hasBestOaLocation W20277850282 @default.
• W2027785028 hasConcept C104317684 @default.
• W2027785028 hasConcept C105702510 @default.
• W2027785028 hasConcept C127561419 @default.
• W2027785028 hasConcept C137620995 @default.
• W2027785028 hasConcept C153911025 @default.
• W2027785028 hasConcept C2776458125 @default.
• W2027785028 hasConcept C2777074287 @default.
• W2027785028 hasConcept C2779324961 @default.
• W2027785028 hasConcept C30145163 @default.
• W2027785028 hasConcept C502942594 @default.
• W2027785028 hasConcept C54355233 @default.
• W2027785028 hasConcept C55493867 @default.
• W2027785028 hasConcept C555283112 @default.
• W2027785028 hasConcept C62478195 @default.
• W2027785028 hasConcept C81885089 @default.
• W2027785028 hasConcept C86803240 @default.
• W2027785028 hasConcept C95444343 @default.
• W2027785028 hasConceptScore W2027785028C104317684 @default.
• W2027785028 hasConceptScore W2027785028C105702510 @default.
• W2027785028 hasConceptScore W2027785028C127561419 @default.
• W2027785028 hasConceptScore W2027785028C137620995 @default.
• W2027785028 hasConceptScore W2027785028C153911025 @default.

• next