FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027794920> ?p ?o ?g. }

• W2027794920 endingPage "1090" @default.
• W2027794920 startingPage "1081" @default.
• W2027794920 abstract "Prostaglandin synthesis by rat testicular tissue was observed to be gonadotrophin and adrenal dependent, and to have the same distribution in the gonad as the steroidogenic enzymes. The synthesis was increased by 5-HT, but decreased by melatonin. Lipid peroxidation increases with age, FSH treament, linoleic and arachidonic acid and melatonin, but was decreased by serotonin, c-AMP, LH, prolactin and ephinephrine. Testicular lysosomes were labilized by LH, adrenal demedullation, testosterone, Vit. A and acetylcholine, but were stabilized by c-AMP, epinephrine and cortisol. Contractility of rat seminiferous tubules was observed to be prostaglandin dependent, stimulated by 5-HT, and inhibited by melatonin and c-AMP. Evidence was obtained indicating that a phospholipase A2 is present in rat testicular lysosomes, and that it is liberated by radiation, heat or certain chemicals. This enzyme hydrolyses PUFA from membrane phospholipids, the former of which are converted into prostaglandins. The prostaglandins appear to initially stimulate contractility of seminiferous tubules, but at higher concentrations they stimulate adenyl cyclase, which increases c-AMP levels in the tubules thereby inhibiting contractility and cellular division. The process of prostaglandin synthesis also produced malonaldehyde, and endoperoxides that contribute to alterations in steroidogenesis by Schiff's base formation and to cellular lysis by membrane permeability changes. Prostaglandins appear to be synthesized physiologically from PUFA derived from cholesterol esters, but pathologically in much larger quantities from membrane phospholipids. Prostaglandins apparently inhibit androgen synthesis by their effects on cholesterol esterase and other steroidogenic enzymes rather than by changing blood flow." @default.
• W2027794920 created "2016-06-24" @default.
• W2027794920 creator A5039494831 @default.
• W2027794920 creator A5040469327 @default.
• W2027794920 creator A5080805866 @default.
• W2027794920 date "1975-06-01" @default.
• W2027794920 modified "2023-10-16" @default.
• W2027794920 title "Mechanisms and interactions in testicular steroidogenesis and prostaglandin synthesis" @default.
• W2027794920 cites W1534185110 @default.
• W2027794920 cites W1548153124 @default.
• W2027794920 cites W1561824493 @default.
• W2027794920 cites W1576901354 @default.
• W2027794920 cites W1960171229 @default.
• W2027794920 cites W1964423926 @default.
• W2027794920 cites W1965815495 @default.
• W2027794920 cites W1967799268 @default.
• W2027794920 cites W1968371092 @default.
• W2027794920 cites W1975309679 @default.
• W2027794920 cites W1977583862 @default.
• W2027794920 cites W1979065558 @default.
• W2027794920 cites W1987056712 @default.
• W2027794920 cites W1988948537 @default.
• W2027794920 cites W1996632666 @default.
• W2027794920 cites W1999875578 @default.
• W2027794920 cites W2001336242 @default.
• W2027794920 cites W2006564336 @default.
• W2027794920 cites W2010559779 @default.
• W2027794920 cites W2011295612 @default.
• W2027794920 cites W2013699950 @default.
• W2027794920 cites W2018693327 @default.
• W2027794920 cites W2021107978 @default.
• W2027794920 cites W2022157661 @default.
• W2027794920 cites W2022303402 @default.
• W2027794920 cites W2027606314 @default.
• W2027794920 cites W2031019445 @default.
• W2027794920 cites W2037301810 @default.
• W2027794920 cites W2037954544 @default.
• W2027794920 cites W2041903250 @default.
• W2027794920 cites W2043708427 @default.
• W2027794920 cites W2044035028 @default.
• W2027794920 cites W2045792216 @default.
• W2027794920 cites W2050018275 @default.
• W2027794920 cites W2054563644 @default.
• W2027794920 cites W2057850047 @default.
• W2027794920 cites W2060081825 @default.
• W2027794920 cites W2063724190 @default.
• W2027794920 cites W2064307579 @default.
• W2027794920 cites W2064722185 @default.
• W2027794920 cites W2067588713 @default.
• W2027794920 cites W2068720507 @default.
• W2027794920 cites W2071403699 @default.
• W2027794920 cites W2072740613 @default.
• W2027794920 cites W2073669343 @default.
• W2027794920 cites W2074377675 @default.
• W2027794920 cites W2076384435 @default.
• W2027794920 cites W2077395798 @default.
• W2027794920 cites W2081167418 @default.
• W2027794920 cites W2088214175 @default.
• W2027794920 cites W2092227042 @default.
• W2027794920 cites W2098614991 @default.
• W2027794920 cites W2154655378 @default.
• W2027794920 cites W2165938024 @default.
• W2027794920 cites W2318515585 @default.
• W2027794920 cites W2347203071 @default.
• W2027794920 cites W2404971165 @default.
• W2027794920 cites W2415843937 @default.
• W2027794920 cites W2470768457 @default.
• W2027794920 cites W305496687 @default.
• W2027794920 cites W31481347 @default.
• W2027794920 doi "https://doi.org/10.1016/0022-4731(75)90353-2" @default.
• W2027794920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/170458" @default.
• W2027794920 hasPublicationYear "1975" @default.
• W2027794920 type Work @default.
• W2027794920 sameAs 2027794920 @default.
• W2027794920 citedByCount "17" @default.
• W2027794920 countsByYear W20277949202021 @default.
• W2027794920 crossrefType "journal-article" @default.
• W2027794920 hasAuthorship W2027794920A5039494831 @default.
• W2027794920 hasAuthorship W2027794920A5040469327 @default.
• W2027794920 hasAuthorship W2027794920A5080805866 @default.
• W2027794920 hasConcept C126322002 @default.
• W2027794920 hasConcept C134018914 @default.
• W2027794920 hasConcept C181199279 @default.
• W2027794920 hasConcept C185592680 @default.
• W2027794920 hasConcept C2778078955 @default.
• W2027794920 hasConcept C2778163477 @default.
• W2027794920 hasConcept C2780664492 @default.
• W2027794920 hasConcept C39133596 @default.
• W2027794920 hasConcept C55493867 @default.
• W2027794920 hasConcept C61322309 @default.
• W2027794920 hasConcept C71924100 @default.
• W2027794920 hasConcept C86803240 @default.
• W2027794920 hasConceptScore W2027794920C126322002 @default.
• W2027794920 hasConceptScore W2027794920C134018914 @default.
• W2027794920 hasConceptScore W2027794920C181199279 @default.
• W2027794920 hasConceptScore W2027794920C185592680 @default.
• W2027794920 hasConceptScore W2027794920C2778078955 @default.
• W2027794920 hasConceptScore W2027794920C2778163477 @default.

• next