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• W2027795919 endingPage "475" @default.
• W2027795919 startingPage "470" @default.
• W2027795919 abstract "Distal airways are believed to be a major site of disease in cystic fibrosis. The product of the CF gene, CFTR, is expressed in non-ciliated bronchiolar epithelial (Clara) cells. Clara cells in primary culture are capable of Cl- secretion which can be stimulated by cAMP and extracellular nucleotides. We used the patch clamp technique to look for Cl- channels in the apical membrane of rabbit Clara cells. In cell-attached patches, we recorded Cl- channels with a conductance for outward currents of 7.5 +/- 0.4 pS (n = 10) and for inward currents of 3.2 +/- 0.5 pS (n = 10); these channels typically exhibited slow kinetics and were not inhibited by the Cl- channel blockers NPPB and DIDS. Channel activity was not noticeably dependent on pipette potential. Addition of chlorophenylthio-cyclic AMP (cpt-cAMP) to the bath increased the percentage of cell-attached patches with active channels (33.8% vs 56.7%; p< 0.05) and the channel open probability (0.49 +/- 0.03 vs 0.84 +/- 0.02; p< 0.05). Extracellular ATP increased the percentage of cell-attached patches with active channels (28.7% to 50.0%; p< 0.05) but had no significant effect on the channel open probability (0.62 +/- 0.07 vs 0.60 +/- 0.06). In conclusion, rabbit non-ciliated bronchiolar epithelial cells express low-conductance Cl- channels that share many similarities with the CFTR-related Cl- channel and are regulated by cAMP and extracellular ATP." @default.
• W2027795919 created "2016-06-24" @default.
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• W2027795919 date "1997-01-01" @default.
• W2027795919 modified "2023-10-02" @default.
• W2027795919 title "CFTR-like Chloride Channels in Non-ciliated Bronchiolar Epithelial (Clara) Cells" @default.
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• W2027795919 doi "https://doi.org/10.1006/bbrc.1996.5939" @default.
• W2027795919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9016805" @default.
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