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- W2027801574 abstract "The histamine H2-receptor antagonist metiamide was evaluated in in vitro and in vivo canine models of immediate-type hypersensitivity reactions. At concentrations of 2 and 4 × 10−4,M, the antagonist significantly increased the amount of histamine present in the medium surrounding passsively sensitized canine lung fragments which had been challenged with ascaris antigen. In contrast, the compound was without effect on the release of a slow reacting substance of anaphylaxis. On the baiis of these observations metiamide was investigated in an in vivo canine model of allergic asthma. At doses of 10, 30 and 50 μmoles/kg, the antagonist did not enhance the ascaris antigen-induced pulmonary pathophysiology. Similarly, at 10 and 50 μmoles/kg metiamide did not alter histamine-induced increases in pulmonary resistance or decreases in dynamic lung compliance. Insofar as the canine model of allergic asthma may be predictive of the human disease, it could be anticipated that the use of histamine H2-receptor antagonistsmay not be deleterious to allergic asthatics." @default.
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- W2027801574 date "1977-07-01" @default.
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- W2027801574 title "The effect of metiamide in in vitro and in vivo canine models of type I hypersensitivity reactions" @default.
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- W2027801574 doi "https://doi.org/10.1016/0014-2999(77)90113-3" @default.
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