FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027802566> ?p ?o ?g. }

• W2027802566 endingPage "545" @default.
• W2027802566 startingPage "541" @default.
• W2027802566 abstract "Background and Aims: Long-term interferon (IFN) therapy is effective in eliminating hepatitis C virus (HCV). However, it carries the risk of adverse effects and reduced quality of life. To assess whether short-term IFN therapy effectively eliminates HCV, we performed a prospective pilot study of pegylated (peg)IFN-α-2a therapy for 8 or 24 weeks. Methods: After excluding patients with high titers of genotype-1, 55 HCV patients received pegIFN-α-2a. Patients who became negative for HCV-RNA at week 2 were allocated to either an 8-week (n = 19) or 24-week (n = 15) course of IFN. We evaluated the efficacy of and tolerance to IFN therapy. Results: The sustained virological response rate was excellent in the two groups (8 weeks, 89.5% [17/19]; 24 weeks, 100% [15/15], respectively,). IFN dose reduction was required in one patient of the 8-week group, but in six patients of the 24-week group (P = 0.028). Treatment was completed by all patients of the 8-week group, but discontinued in five patients of the 24-week group (P = 0.011). Conclusions: The 8-week IFN therapy is more tolerable than the 24-week therapy and had similar outcomes. Excluding the patients with high titers of genotype-1, we recommend switching to an 8-week course of pegIFN-α monotherapy once patients show an ultra rapid virological response at week 2 from the start of IFN therapy." @default.
• W2027802566 created "2016-06-24" @default.
• W2027802566 creator A5016882648 @default.
• W2027802566 creator A5019195799 @default.
• W2027802566 creator A5019763674 @default.
• W2027802566 creator A5021748063 @default.
• W2027802566 creator A5022256896 @default.
• W2027802566 creator A5022484621 @default.
• W2027802566 creator A5023958825 @default.
• W2027802566 creator A5026178160 @default.
• W2027802566 creator A5031365119 @default.
• W2027802566 creator A5034077858 @default.
• W2027802566 creator A5037963685 @default.
• W2027802566 creator A5041506585 @default.
• W2027802566 creator A5073894165 @default.
• W2027802566 creator A5084015574 @default.
• W2027802566 creator A5087512403 @default.
• W2027802566 date "2008-04-01" @default.
• W2027802566 modified "2023-09-23" @default.
• W2027802566 title "Prospective study of short-term peginterferon-α-2a monotherapy in patients who had a virological response at 2 weeks after initiation of interferon therapy" @default.
• W2027802566 cites W1970053808 @default.
• W2027802566 cites W1978339383 @default.
• W2027802566 cites W1985882441 @default.
• W2027802566 cites W1990238774 @default.
• W2027802566 cites W1998901422 @default.
• W2027802566 cites W2015533723 @default.
• W2027802566 cites W2016685244 @default.
• W2027802566 cites W2026613864 @default.
• W2027802566 cites W2027545702 @default.
• W2027802566 cites W2052343877 @default.
• W2027802566 cites W2053831785 @default.
• W2027802566 cites W2077589807 @default.
• W2027802566 cites W2077757909 @default.
• W2027802566 cites W2079377965 @default.
• W2027802566 cites W2081773608 @default.
• W2027802566 cites W2087523275 @default.
• W2027802566 cites W2088053309 @default.
• W2027802566 cites W2112876622 @default.
• W2027802566 cites W2127685726 @default.
• W2027802566 cites W2132290252 @default.
• W2027802566 cites W2147029378 @default.
• W2027802566 cites W2165298960 @default.
• W2027802566 cites W2332630894 @default.
• W2027802566 cites W2334978547 @default.
• W2027802566 cites W4232907328 @default.
• W2027802566 cites W4235441957 @default.
• W2027802566 cites W4237048735 @default.
• W2027802566 cites W4242105639 @default.
• W2027802566 cites W4249456542 @default.
• W2027802566 cites W4254772901 @default.
• W2027802566 doi "https://doi.org/10.1111/j.1440-1746.2008.05356.x" @default.
• W2027802566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18397484" @default.
• W2027802566 hasPublicationYear "2008" @default.
• W2027802566 type Work @default.
• W2027802566 sameAs 2027802566 @default.
• W2027802566 citedByCount "7" @default.
• W2027802566 countsByYear W20278025662012 @default.
• W2027802566 countsByYear W20278025662016 @default.
• W2027802566 crossrefType "journal-article" @default.
• W2027802566 hasAuthorship W2027802566A5016882648 @default.
• W2027802566 hasAuthorship W2027802566A5019195799 @default.
• W2027802566 hasAuthorship W2027802566A5019763674 @default.
• W2027802566 hasAuthorship W2027802566A5021748063 @default.
• W2027802566 hasAuthorship W2027802566A5022256896 @default.
• W2027802566 hasAuthorship W2027802566A5022484621 @default.
• W2027802566 hasAuthorship W2027802566A5023958825 @default.
• W2027802566 hasAuthorship W2027802566A5026178160 @default.
• W2027802566 hasAuthorship W2027802566A5031365119 @default.
• W2027802566 hasAuthorship W2027802566A5034077858 @default.
• W2027802566 hasAuthorship W2027802566A5037963685 @default.
• W2027802566 hasAuthorship W2027802566A5041506585 @default.
• W2027802566 hasAuthorship W2027802566A5073894165 @default.
• W2027802566 hasAuthorship W2027802566A5084015574 @default.
• W2027802566 hasAuthorship W2027802566A5087512403 @default.
• W2027802566 hasConcept C126322002 @default.
• W2027802566 hasConcept C141071460 @default.
• W2027802566 hasConcept C188816634 @default.
• W2027802566 hasConcept C197934379 @default.
• W2027802566 hasConcept C203014093 @default.
• W2027802566 hasConcept C2522874641 @default.
• W2027802566 hasConcept C2776178377 @default.
• W2027802566 hasConcept C2776408679 @default.
• W2027802566 hasConcept C2776461080 @default.
• W2027802566 hasConcept C2776999253 @default.
• W2027802566 hasConcept C2780040827 @default.
• W2027802566 hasConcept C32611913 @default.
• W2027802566 hasConcept C71924100 @default.
• W2027802566 hasConcept C90924648 @default.
• W2027802566 hasConceptScore W2027802566C126322002 @default.
• W2027802566 hasConceptScore W2027802566C141071460 @default.
• W2027802566 hasConceptScore W2027802566C188816634 @default.
• W2027802566 hasConceptScore W2027802566C197934379 @default.
• W2027802566 hasConceptScore W2027802566C203014093 @default.
• W2027802566 hasConceptScore W2027802566C2522874641 @default.
• W2027802566 hasConceptScore W2027802566C2776178377 @default.
• W2027802566 hasConceptScore W2027802566C2776408679 @default.
• W2027802566 hasConceptScore W2027802566C2776461080 @default.
• W2027802566 hasConceptScore W2027802566C2776999253 @default.

• next