FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027805446> ?p ?o ?g. }

• W2027805446 endingPage "1939" @default.
• W2027805446 startingPage "1931" @default.
• W2027805446 abstract "Complement C4b-binding protein (C4BP) is a plasma protein synthesized in the liver and plays a regulatory role in the host defense complement system. We have previously reported that mRNAs of the C4BP alpha chain (C4BPalpha) are expressed at significant levels in the guinea pig and mouse epididymis in an androgen-dependent manner. Here, we analyze the murine C4bpa gene and show that epididymal and liver C4BPalpha mRNAs are generated from a single-copy gene and that the epididymal C4BPalpha mRNAs are transcribed from novel transcription start sites located approximately 100 base pairs downstream from those used in the liver. Furthermore, in an immunohistochemical study using rabbit anti-mouse C4BP antiserum, we demonstrated that C4BP is localized in the stereocilia and Golgi apparatus of the epididymal epithelial cells and the surfaces of spermatozoa in the lumen in the region from the distal caput to the cauda but not in the proximal caput region. Indirect immunofluorescence of the isolated spermatozoa demonstrated that C4BP is localized preferentially on the head region of the spermatozoa, and immunoelectron microscopy located C4BP on the plasma membrane and the outer acrosomal membrane. These results indicate that epididymal C4BP is synthesized in the epithelial cells and secreted into the lumen in a region-restricted manner and is taken up to the sperm membranes on passage through the epididymis. Many epididymal proteins are secreted from the epithelial cells in a region-specific and androgen-dependent manner and are considered to contribute to sperm maturation. Our findings suggest a novel function of C4BP as one such epididymal secretory protein." @default.
• W2027805446 created "2016-06-24" @default.
• W2027805446 creator A5022635956 @default.
• W2027805446 creator A5024081838 @default.
• W2027805446 creator A5031040915 @default.
• W2027805446 creator A5042028765 @default.
• W2027805446 creator A5044108856 @default.
• W2027805446 creator A5069038207 @default.
• W2027805446 creator A5070873839 @default.
• W2027805446 creator A5089568887 @default.
• W2027805446 date "2003-12-01" @default.
• W2027805446 modified "2023-10-14" @default.
• W2027805446 title "Complement C4b-Binding Protein as a Novel Murine Epididymal Secretory Protein" @default.
• W2027805446 cites W1491891405 @default.
• W2027805446 cites W1498492115 @default.
• W2027805446 cites W1500833770 @default.
• W2027805446 cites W1506067219 @default.
• W2027805446 cites W1514303750 @default.
• W2027805446 cites W1542346752 @default.
• W2027805446 cites W1542378870 @default.
• W2027805446 cites W1547117143 @default.
• W2027805446 cites W1557276078 @default.
• W2027805446 cites W1571928728 @default.
• W2027805446 cites W1641276090 @default.
• W2027805446 cites W167480335 @default.
• W2027805446 cites W1792025947 @default.
• W2027805446 cites W1829121251 @default.
• W2027805446 cites W1837186493 @default.
• W2027805446 cites W1909911857 @default.
• W2027805446 cites W1925362145 @default.
• W2027805446 cites W1963610024 @default.
• W2027805446 cites W1972174938 @default.
• W2027805446 cites W1974305168 @default.
• W2027805446 cites W1976815808 @default.
• W2027805446 cites W1978308641 @default.
• W2027805446 cites W2006289565 @default.
• W2027805446 cites W2007642085 @default.
• W2027805446 cites W2008069172 @default.
• W2027805446 cites W2020729765 @default.
• W2027805446 cites W2027986001 @default.
• W2027805446 cites W2028082143 @default.
• W2027805446 cites W2028501275 @default.
• W2027805446 cites W2034281339 @default.
• W2027805446 cites W2035447276 @default.
• W2027805446 cites W2041599294 @default.
• W2027805446 cites W2044605080 @default.
• W2027805446 cites W2053613707 @default.
• W2027805446 cites W2068461647 @default.
• W2027805446 cites W2076353777 @default.
• W2027805446 cites W2077320485 @default.
• W2027805446 cites W2080663504 @default.
• W2027805446 cites W2104994844 @default.
• W2027805446 cites W2116545788 @default.
• W2027805446 cites W2116559065 @default.
• W2027805446 cites W2120980915 @default.
• W2027805446 cites W2123190818 @default.
• W2027805446 cites W2127025222 @default.
• W2027805446 cites W2131595245 @default.
• W2027805446 cites W2140596011 @default.
• W2027805446 cites W2149952970 @default.
• W2027805446 cites W2153551973 @default.
• W2027805446 cites W2336513514 @default.
• W2027805446 doi "https://doi.org/10.1095/biolreprod.103.020289" @default.
• W2027805446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12930719" @default.
• W2027805446 hasPublicationYear "2003" @default.
• W2027805446 type Work @default.
• W2027805446 sameAs 2027805446 @default.
• W2027805446 citedByCount "6" @default.
• W2027805446 countsByYear W20278054462015 @default.
• W2027805446 crossrefType "journal-article" @default.
• W2027805446 hasAuthorship W2027805446A5022635956 @default.
• W2027805446 hasAuthorship W2027805446A5024081838 @default.
• W2027805446 hasAuthorship W2027805446A5031040915 @default.
• W2027805446 hasAuthorship W2027805446A5042028765 @default.
• W2027805446 hasAuthorship W2027805446A5044108856 @default.
• W2027805446 hasAuthorship W2027805446A5069038207 @default.
• W2027805446 hasAuthorship W2027805446A5070873839 @default.
• W2027805446 hasAuthorship W2027805446A5089568887 @default.
• W2027805446 hasConcept C104317684 @default.
• W2027805446 hasConcept C111684460 @default.
• W2027805446 hasConcept C153911025 @default.
• W2027805446 hasConcept C156399914 @default.
• W2027805446 hasConcept C159654299 @default.
• W2027805446 hasConcept C203014093 @default.
• W2027805446 hasConcept C2781087480 @default.
• W2027805446 hasConcept C2781254305 @default.
• W2027805446 hasConcept C2993140218 @default.
• W2027805446 hasConcept C55493867 @default.
• W2027805446 hasConcept C59822182 @default.
• W2027805446 hasConcept C86803240 @default.
• W2027805446 hasConcept C95444343 @default.
• W2027805446 hasConceptScore W2027805446C104317684 @default.
• W2027805446 hasConceptScore W2027805446C111684460 @default.
• W2027805446 hasConceptScore W2027805446C153911025 @default.
• W2027805446 hasConceptScore W2027805446C156399914 @default.
• W2027805446 hasConceptScore W2027805446C159654299 @default.
• W2027805446 hasConceptScore W2027805446C203014093 @default.
• W2027805446 hasConceptScore W2027805446C2781087480 @default.

• next