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• W2027824469 abstract "The structure-activity relationships for a series of pyrazine-based A2B adenosine receptor antagonists are described. From this work, LAS101057 (17), a potent, selective, and orally efficacious A2B receptor antagonist, was identified as a clinical development candidate. LAS101057 inhibits agonist-induced IL-6 production in human fibroblasts and is active in an ovalbumin (OVA)-sensitized mouse model after oral administration, reducing airway hyperresponsiveness to methacholine, Th2 cytokine production, and OVA-specific IgE levels." @default.
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• W2027824469 date "2010-12-20" @default.
• W2027824469 modified "2023-10-18" @default.
• W2027824469 title "Discovery of LAS101057: A Potent, Selective, and Orally Efficacious A2B Adenosine Receptor Antagonist" @default.
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• W2027824469 doi "https://doi.org/10.1021/ml100249e" @default.
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