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• W2027829168 abstract "Human LCAT-like lysophospholipase (LLPL), or lysophospholipase 3, was first identified in vitro, in foam cells derived from THP-1 cells. We demonstrated that LLPL was present in foam cells in the severe atherosclerotic lesions that develop in apolipoprotein E-null (apoE−/−) mice. This indicated that LLPL might affect lipid metabolisms in foam cells and, therefore, atherogenesis. Accordingly, we created LLPL-knockout mice by gene targeting and crossed them with apoE−/− mice. We showed that the absence of LLPL increased lesion formation markedly in apoE−/− mice but had little effect on the plasma-lipid profile. In addition, LLPL-deficient peritoneal macrophages were more sensitive to apoptosis induced by exposure to oxidized low-density lipoprotein. LLPL might provide a link between apoptosis in macrophages and atherogenesis. Our data demonstrate that LLPL activity is anti-atherogenic and indicate that the regulation of this enzyme might be a novel drug target for the treatment of atherosclerosis." @default.
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• W2027829168 date "2005-04-01" @default.
• W2027829168 modified "2023-10-16" @default.
• W2027829168 title "Loss of lysophospholipase 3 increases atherosclerosis in apolipoprotein E-deficient mice" @default.
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• W2027829168 doi "https://doi.org/10.1016/j.bbrc.2005.02.126" @default.
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