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• W2027831189 startingPage "48" @default.
• W2027831189 abstract "An increasing number of studies implicate the GABAAergic system in the pathophysiology of the fragile X syndrome, a frequent cause of intellectual disability and autism. Animal models have proven invaluable in unravelling the molecular mechanisms underlying the disorder. Multiple defects in this inhibitory system have been identified in Fmr1 knockout mice, including altered expression of various components, aberrant GABAA receptor-mediated signalling, altered GABA concentrations and anatomical defects in GABAergic neurons. Aberrations compatible with those described in the mouse model were detected in dfmr1 deficient Drosophila melanogaster, a validated fly model for the fragile X syndrome. Treatment with drugs that ameliorate the GABAAergic deficiency in both animal models have demonstrated that the GABAA receptor is a promising target for the treatment of fragile X patients. Based on these preclinical studies, clinical trials in patients have been initiated. This article is part of the Special Issue entitled ‘GABAergic Signaling in Health and Disease’." @default.
• W2027831189 created "2016-06-24" @default.
• W2027831189 creator A5061806634 @default.
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• W2027831189 date "2015-01-01" @default.
• W2027831189 modified "2023-10-10" @default.
• W2027831189 title "Insights into GABAAergic system deficits in fragile X syndrome lead to clinical trials" @default.
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• W2027831189 doi "https://doi.org/10.1016/j.neuropharm.2014.06.028" @default.
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