FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027831415> ?p ?o ?g. }

• W2027831415 endingPage "1025" @default.
• W2027831415 startingPage "1019" @default.
• W2027831415 abstract "In patients with primary immunodeficiencies the role of natural killer (NK)- and lymphokine (IL-2)-activated killer (LAK)-cells is not yet satisfactorily established. Using a clonogenic assay with K562 leukemia target cells, we studied their NK- and LAK-cell activity in vitro. Moreover, the effect of thymosin alpha 1 (T alpha 1) on LAK-cell activity was studied in 11 patients with different immunodeficiencies. The results were compared with data of healthy controls (n = 11) and cord blood samples (n = 6). Common variable immunodeficiency patients demonstrated a mean LAK-cell activity of about 65% of normal controls and cord blood samples. The moderately reduced LAK-cell activity was not affected by T alpha 1. In the immunodeficient other patients, low levels of LAK-cell activity with a mean value of 10% of normal controls were seen. The mean LAK-cell activity could be improved by T alpha 1: three patients showed an improvement of their LAK-cell activity up to 25-30% after T alpha 1 administration in vitro, but in one case T alpha 1 was without any effect. Analysis of the expression of the surface markers CD8, CD16, CD57 and CD8/CD57 revealed that only CD16 positive lymphocytes were significantly less in immunodeficient patients. We found a linear correlation between LAK-cell activity and CD8/CD57 double positive lymphocytes in all patients. Our results demonstrate that suppressed LAK-cell activity from immunodeficient patients can be individually improved by T alpha 1. Further in vivo studies should evaluate thymic peptide immunotherapy for individual immunodeficient patients." @default.
• W2027831415 created "2016-06-24" @default.
• W2027831415 creator A5017514499 @default.
• W2027831415 creator A5029253754 @default.
• W2027831415 creator A5041372912 @default.
• W2027831415 creator A5072344485 @default.
• W2027831415 creator A5083725831 @default.
• W2027831415 date "1994-12-01" @default.
• W2027831415 modified "2023-10-10" @default.
• W2027831415 title "Thymosin α1 effects, in vitro, on lymphokine-activated killer cells from patients with primary immunodeficiencies: Preliminary results" @default.
• W2027831415 cites W135613135 @default.
• W2027831415 cites W1595482840 @default.
• W2027831415 cites W1968235443 @default.
• W2027831415 cites W1971436729 @default.
• W2027831415 cites W1973365837 @default.
• W2027831415 cites W1985279776 @default.
• W2027831415 cites W1991375564 @default.
• W2027831415 cites W1996478245 @default.
• W2027831415 cites W2019134681 @default.
• W2027831415 cites W2026495947 @default.
• W2027831415 cites W2040199964 @default.
• W2027831415 cites W2052747235 @default.
• W2027831415 cites W2060216665 @default.
• W2027831415 cites W2063209691 @default.
• W2027831415 cites W2078089070 @default.
• W2027831415 cites W2146814362 @default.
• W2027831415 cites W4245326899 @default.
• W2027831415 doi "https://doi.org/10.1016/0192-0561(94)90081-7" @default.
• W2027831415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7705963" @default.
• W2027831415 hasPublicationYear "1994" @default.
• W2027831415 type Work @default.
• W2027831415 sameAs 2027831415 @default.
• W2027831415 citedByCount "16" @default.
• W2027831415 countsByYear W20278314152015 @default.
• W2027831415 countsByYear W20278314152020 @default.
• W2027831415 countsByYear W20278314152023 @default.
• W2027831415 crossrefType "journal-article" @default.
• W2027831415 hasAuthorship W2027831415A5017514499 @default.
• W2027831415 hasAuthorship W2027831415A5029253754 @default.
• W2027831415 hasAuthorship W2027831415A5041372912 @default.
• W2027831415 hasAuthorship W2027831415A5072344485 @default.
• W2027831415 hasAuthorship W2027831415A5083725831 @default.
• W2027831415 hasConcept C114684123 @default.
• W2027831415 hasConcept C129374314 @default.
• W2027831415 hasConcept C154317977 @default.
• W2027831415 hasConcept C167672396 @default.
• W2027831415 hasConcept C171122931 @default.
• W2027831415 hasConcept C202751555 @default.
• W2027831415 hasConcept C203014093 @default.
• W2027831415 hasConcept C2776451592 @default.
• W2027831415 hasConcept C2777371288 @default.
• W2027831415 hasConcept C2778102761 @default.
• W2027831415 hasConcept C2778461978 @default.
• W2027831415 hasConcept C2780914630 @default.
• W2027831415 hasConcept C2781462264 @default.
• W2027831415 hasConcept C28651165 @default.
• W2027831415 hasConcept C49382859 @default.
• W2027831415 hasConcept C55493867 @default.
• W2027831415 hasConcept C71924100 @default.
• W2027831415 hasConcept C86803240 @default.
• W2027831415 hasConcept C8891405 @default.
• W2027831415 hasConceptScore W2027831415C114684123 @default.
• W2027831415 hasConceptScore W2027831415C129374314 @default.
• W2027831415 hasConceptScore W2027831415C154317977 @default.
• W2027831415 hasConceptScore W2027831415C167672396 @default.
• W2027831415 hasConceptScore W2027831415C171122931 @default.
• W2027831415 hasConceptScore W2027831415C202751555 @default.
• W2027831415 hasConceptScore W2027831415C203014093 @default.
• W2027831415 hasConceptScore W2027831415C2776451592 @default.
• W2027831415 hasConceptScore W2027831415C2777371288 @default.
• W2027831415 hasConceptScore W2027831415C2778102761 @default.
• W2027831415 hasConceptScore W2027831415C2778461978 @default.
• W2027831415 hasConceptScore W2027831415C2780914630 @default.
• W2027831415 hasConceptScore W2027831415C2781462264 @default.
• W2027831415 hasConceptScore W2027831415C28651165 @default.
• W2027831415 hasConceptScore W2027831415C49382859 @default.
• W2027831415 hasConceptScore W2027831415C55493867 @default.
• W2027831415 hasConceptScore W2027831415C71924100 @default.
• W2027831415 hasConceptScore W2027831415C86803240 @default.
• W2027831415 hasConceptScore W2027831415C8891405 @default.
• W2027831415 hasIssue "12" @default.
• W2027831415 hasLocation W20278314151 @default.
• W2027831415 hasLocation W20278314152 @default.
• W2027831415 hasOpenAccess W2027831415 @default.
• W2027831415 hasPrimaryLocation W20278314151 @default.
• W2027831415 hasRelatedWork W1540489232 @default.
• W2027831415 hasRelatedWork W187585909 @default.
• W2027831415 hasRelatedWork W1932211409 @default.
• W2027831415 hasRelatedWork W1967360579 @default.
• W2027831415 hasRelatedWork W1978551452 @default.
• W2027831415 hasRelatedWork W1999186358 @default.
• W2027831415 hasRelatedWork W2008172615 @default.
• W2027831415 hasRelatedWork W2096574716 @default.
• W2027831415 hasRelatedWork W2133759650 @default.
• W2027831415 hasRelatedWork W2166826644 @default.
• W2027831415 hasVolume "16" @default.
• W2027831415 isParatext "false" @default.
• W2027831415 isRetracted "false" @default.

• next