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- W2027831911 abstract "Partially purified populations of mouse spleen cells have been previously separated by equilibrium centrifugation on bovine serum albumin gradients and it has been suggested that separate fractions which are unique by several criteria contain precursors of plaque-forming cells (PFC) at different stages of differentiation. One of the unique features of these populations was the medium requirements. By making use of permissive and nonpermissive culture conditions, differentiation stages were demonstrable and a mechanism by which cultures regulate the amount of immunogen was detectable. These result are interpreted as being consistent with normal spleen cells having precursors at different stages of differentiation. It is also suggested that there is competition between the triggering of cells by antigen and the sequestration of antigen, presumably by macrophages." @default.
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- W2027831911 date "1973-04-01" @default.
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- W2027831911 title "In vitro immune response of partially purified spleen cells: Nutritionally distinct stages in differentiation" @default.
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- W2027831911 doi "https://doi.org/10.1016/0008-8749(73)90179-2" @default.
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