FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027833096> ?p ?o ?g. }

• W2027833096 endingPage "198" @default.
• W2027833096 startingPage "188" @default.
• W2027833096 abstract "Fyn tyrosine kinase is thought to be involved in the control of neuronal intracellular signal transduction elicited by neurotransmitter stimulation. Emotional disorders, such as fearfulness in Fyn-deficient mice, prompted us to investigate the neural mechanisms that lead to defective emotional expression by using functional neuroanatomical methods. In order to examine the reactivity of a specific neural network to excitatory neurotransmitter administration, we mapped the distribution of c-Fos-immunoreactive neurons after administering N-methyl-D-aspartate (NMDA) to control and mutant mice at the subthreshold dose for seizure induction. The induction of neuronal c-Fos-immunoreactivity by NMDA was enhanced in the Fyn-deficient mice, and there was a much greater increase in immunopositive neurons in certain well-defined areas, such as the amygdaloid medial nuclear subdivisions, hypothalamic paraventricular nucleus, and midbrain periaqueductal gray, of the mutant. NMDA-induced c-Fos expression was attenuated by pretreatment with D-(-)-2-amino-5-phosphonovaleric acid, a competitive NMDA antagonist, both in the control and the mutant mice. These findings suggest that the excitability of the projection system from the amygdala to the hypothalamus and midbrain, the main pathways of emotional expression, is enhanced in Fyn-deficient mice." @default.
• W2027833096 created "2016-06-24" @default.
• W2027833096 creator A5057142349 @default.
• W2027833096 creator A5059541604 @default.
• W2027833096 creator A5060262806 @default.
• W2027833096 creator A5067009952 @default.
• W2027833096 creator A5090753623 @default.
• W2027833096 date "2001-06-01" @default.
• W2027833096 modified "2023-10-10" @default.
• W2027833096 title "N-Methyl-d-aspartate-induced c-Fos expression is enhanced in the forebrain structures related to emotion in Fyn-deficient mice" @default.
• W2027833096 cites W1524996824 @default.
• W2027833096 cites W1618945825 @default.
• W2027833096 cites W1859114794 @default.
• W2027833096 cites W1964048868 @default.
• W2027833096 cites W1967318820 @default.
• W2027833096 cites W1975944686 @default.
• W2027833096 cites W1978329946 @default.
• W2027833096 cites W1982128763 @default.
• W2027833096 cites W1984057909 @default.
• W2027833096 cites W1990015622 @default.
• W2027833096 cites W1990625157 @default.
• W2027833096 cites W1999438189 @default.
• W2027833096 cites W2003102216 @default.
• W2027833096 cites W2004192630 @default.
• W2027833096 cites W2009999305 @default.
• W2027833096 cites W2011934699 @default.
• W2027833096 cites W2021207961 @default.
• W2027833096 cites W2024431713 @default.
• W2027833096 cites W2031039443 @default.
• W2027833096 cites W2035071372 @default.
• W2027833096 cites W2038424162 @default.
• W2027833096 cites W2039844097 @default.
• W2027833096 cites W2040367183 @default.
• W2027833096 cites W2047517404 @default.
• W2027833096 cites W2050251142 @default.
• W2027833096 cites W2054760165 @default.
• W2027833096 cites W2055368017 @default.
• W2027833096 cites W2057823315 @default.
• W2027833096 cites W2058601367 @default.
• W2027833096 cites W2067286606 @default.
• W2027833096 cites W2090501101 @default.
• W2027833096 cites W2091497325 @default.
• W2027833096 cites W2094873905 @default.
• W2027833096 cites W2122155768 @default.
• W2027833096 cites W2125517953 @default.
• W2027833096 cites W2155683150 @default.
• W2027833096 cites W2396366075 @default.
• W2027833096 cites W2416825797 @default.
• W2027833096 cites W4232573973 @default.
• W2027833096 cites W4323284022 @default.
• W2027833096 doi "https://doi.org/10.1016/s0006-8993(01)02534-3" @default.
• W2027833096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11423094" @default.
• W2027833096 hasPublicationYear "2001" @default.
• W2027833096 type Work @default.
• W2027833096 sameAs 2027833096 @default.
• W2027833096 citedByCount "10" @default.
• W2027833096 crossrefType "journal-article" @default.
• W2027833096 hasAuthorship W2027833096A5057142349 @default.
• W2027833096 hasAuthorship W2027833096A5059541604 @default.
• W2027833096 hasAuthorship W2027833096A5060262806 @default.
• W2027833096 hasAuthorship W2027833096A5067009952 @default.
• W2027833096 hasAuthorship W2027833096A5090753623 @default.
• W2027833096 hasConcept C126322002 @default.
• W2027833096 hasConcept C134018914 @default.
• W2027833096 hasConcept C169760540 @default.
• W2027833096 hasConcept C170493617 @default.
• W2027833096 hasConcept C185592680 @default.
• W2027833096 hasConcept C2776219046 @default.
• W2027833096 hasConcept C2776552330 @default.
• W2027833096 hasConcept C2779144063 @default.
• W2027833096 hasConcept C2779715522 @default.
• W2027833096 hasConcept C37686147 @default.
• W2027833096 hasConcept C42362537 @default.
• W2027833096 hasConcept C529278444 @default.
• W2027833096 hasConcept C55493867 @default.
• W2027833096 hasConcept C62478195 @default.
• W2027833096 hasConcept C67018056 @default.
• W2027833096 hasConcept C71924100 @default.
• W2027833096 hasConcept C86803240 @default.
• W2027833096 hasConcept C95444343 @default.
• W2027833096 hasConceptScore W2027833096C126322002 @default.
• W2027833096 hasConceptScore W2027833096C134018914 @default.
• W2027833096 hasConceptScore W2027833096C169760540 @default.
• W2027833096 hasConceptScore W2027833096C170493617 @default.
• W2027833096 hasConceptScore W2027833096C185592680 @default.
• W2027833096 hasConceptScore W2027833096C2776219046 @default.
• W2027833096 hasConceptScore W2027833096C2776552330 @default.
• W2027833096 hasConceptScore W2027833096C2779144063 @default.
• W2027833096 hasConceptScore W2027833096C2779715522 @default.
• W2027833096 hasConceptScore W2027833096C37686147 @default.
• W2027833096 hasConceptScore W2027833096C42362537 @default.
• W2027833096 hasConceptScore W2027833096C529278444 @default.
• W2027833096 hasConceptScore W2027833096C55493867 @default.
• W2027833096 hasConceptScore W2027833096C62478195 @default.
• W2027833096 hasConceptScore W2027833096C67018056 @default.
• W2027833096 hasConceptScore W2027833096C71924100 @default.
• W2027833096 hasConceptScore W2027833096C86803240 @default.
• W2027833096 hasConceptScore W2027833096C95444343 @default.

• next