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• W2027834425 abstract "Polycyclic terpenoid lipids such as hopanes and steranes have been widely used to understand ancient biology, Earth history, and the oxygenation of the ocean-atmosphere system. Some of these lipids are believed to be produced only by aerobic organisms, whereas others actually require molecular oxygen for their biosynthesis. A persistent question remains: Did some polycyclic lipids initially evolve in response to certain environmental or metabolic stresses, including the presence of oxygen? Here, we identify tetracyclic isoprenoids in spores of the bacterium Bacillus subtilis. We call them sporulenes. They are produced by cyclization of regular polyprenes, a reaction that is more favorable chemically than the formation of terpenoids such as hopanoids and steroids from squalene. The simplicity of the reaction suggests that the B. subtilis cyclase may be analogous to evolutionarily ancient cyclases. We show that these molecules increase the resistance of spores to a reactive oxygen species, demonstrating a specific physiological role for a nonpigment bacterial lipid biomarker. Geostable derivatives of these compounds in sediments could thus be used as direct indicators of oxidative stress and aerobic environments." @default.
• W2027834425 created "2016-06-24" @default.
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• W2027834425 date "2008-05-06" @default.
• W2027834425 modified "2023-10-09" @default.
• W2027834425 title "A polycyclic terpenoid that alleviates oxidative stress" @default.
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• W2027834425 doi "https://doi.org/10.1073/pnas.0800199105" @default.
• W2027834425 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2373358" @default.
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