FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027834534> ?p ?o ?g. }

• W2027834534 abstract "Insulin-like growth factor-I (IGF-I) mediates many of the effects of growth hormone (GH). The regulation of IGF-I, independent of GH, is methodologically difficult to assess in vivo, as hypophysectomy results in derangement of many pituitary hormone axes in addition to GH, and a gene knockout model is not available. The recessive sex-linked dwarfing (SLD) gene (dw) in chickens results in a lack of functional target tissue GH receptors due to a variety of molecular defects, which provides a unique model for evaluating GH-independent regulation of IGF-I. In the present study, the impact of 3,3', 5-triiodo-l-thyronine (T3) on circulating and tissue IGF-I was determined in normal versus SLD birds. Adult, nonovulatory female normal and SLD chickens were restrict-fed 40 g of feed/kg bw/day containing 0, 0.5, or 1.0 ppm T3, resulting in supplementation levels of 0 (control), 20 (low dose), or 40 (high dose) microg T3/kg bw/day for 10 days. Samples of GH target tissues including liver, abdominal fat pad, skeletal muscle (pectoralis major), and spleen were extracted and assayed for IGF-I. Plasma T3, T4, GH, and IGF-I were determined by homologous RIA. Tissue GH binding was determined for hepatic membranes by radioreceptor assay. Under control conditions, dwarf chickens were markedly hypersomatotropic (33.3 +/- 4.1 ng GH/ml plasma; mean +/- SEM) compared to normals (2.4 +/- 3.9 ng/ml), and T3 supplementation reduced this to normal levels. Despite the high circulating level of GH in dwarfs, plasma IGF-I was low compared to normal controls (dwarfs 1.5 +/- .9 ng/ml; normals 5. 3 +/- .9 ng/ml; P = 0.004), but this difference was eliminated with low-dose T3. In this study, tissue IGF-I was undetectable in liver and pectoralis muscle in adults (55 weeks of age) of both genotypes, under all treatments. In contrast, adipose tissue IGF-I was relatively high and did not differ (P = 0.84) between genotypes under control conditions (normals 776.5 +/- 236.7; dwarfs 844.6 +/- 236.7 pg/mg protein), but was increased in normals and decreased in dwarfs, resulting in higher levels (P = 0.02) in the normal (1249.9 +/- 200.0 pg/mg protein) than in the dwarf genotype (558.4 +/- 200.0 pg/mg protein) at the higher level of T3 supplementation. This relationship was somewhat reversed in spleen, where T3 tended to decrease tissue IGF-I concentration in normals and increase it in dwarfs. The low level of plasma IGF-I despite nonmeasureable hepatic IGF-I tissue concentrations suggests that IGF-I synthesis by extrahepatic tissues contributes to the circulating pool of IGF-I. The relatively high control levels of adipose tissue IGF-I in the dwarf genotype further suggest that considerable IGF-I synthesis exists that is GH-independent in this extrahepatic tissue. The presence of GH action, however, may mediate the effects of other hormones that can influence local IGF-I production in this tissue, as reflected by the differential response to T3 supplementation between genotypes. The tissue-specific nature of the effect of T3 on IGF-I production supports an additional point of regulation of hormone action at the target tissue level." @default.
• W2027834534 created "2016-06-24" @default.
• W2027834534 creator A5013767235 @default.
• W2027834534 creator A5058123951 @default.
• W2027834534 creator A5064883394 @default.
• W2027834534 creator A5078443574 @default.
• W2027834534 date "1997-01-01" @default.
• W2027834534 modified "2023-09-24" @default.
• W2027834534 title "Tissue-Specific Alterations in Insulin-like Growth Factor-I Concentrations in Response to 3,3′,5-Triiodo-l-thyronine Supplementation in the Growth Hormone Receptor-Deficient Sex-Linked Dwarf Chicken" @default.
• W2027834534 doi "https://doi.org/10.1006/gcen.1996.6795" @default.
• W2027834534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9000465" @default.
• W2027834534 hasPublicationYear "1997" @default.
• W2027834534 type Work @default.
• W2027834534 sameAs 2027834534 @default.
• W2027834534 citedByCount "19" @default.
• W2027834534 countsByYear W20278345342012 @default.
• W2027834534 countsByYear W20278345342013 @default.
• W2027834534 countsByYear W20278345342019 @default.
• W2027834534 countsByYear W20278345342021 @default.
• W2027834534 countsByYear W20278345342022 @default.
• W2027834534 crossrefType "journal-article" @default.
• W2027834534 hasAuthorship W2027834534A5013767235 @default.
• W2027834534 hasAuthorship W2027834534A5058123951 @default.
• W2027834534 hasAuthorship W2027834534A5064883394 @default.
• W2027834534 hasAuthorship W2027834534A5078443574 @default.
• W2027834534 hasConcept C104317684 @default.
• W2027834534 hasConcept C113675107 @default.
• W2027834534 hasConcept C126322002 @default.
• W2027834534 hasConcept C134018914 @default.
• W2027834534 hasConcept C16896131 @default.
• W2027834534 hasConcept C170493617 @default.
• W2027834534 hasConcept C2775960820 @default.
• W2027834534 hasConcept C2778111144 @default.
• W2027834534 hasConcept C2778288131 @default.
• W2027834534 hasConcept C2779306644 @default.
• W2027834534 hasConcept C2780104272 @default.
• W2027834534 hasConcept C2780689927 @default.
• W2027834534 hasConcept C2984496839 @default.
• W2027834534 hasConcept C55493867 @default.
• W2027834534 hasConcept C71315377 @default.
• W2027834534 hasConcept C71924100 @default.
• W2027834534 hasConcept C86803240 @default.
• W2027834534 hasConceptScore W2027834534C104317684 @default.
• W2027834534 hasConceptScore W2027834534C113675107 @default.
• W2027834534 hasConceptScore W2027834534C126322002 @default.
• W2027834534 hasConceptScore W2027834534C134018914 @default.
• W2027834534 hasConceptScore W2027834534C16896131 @default.
• W2027834534 hasConceptScore W2027834534C170493617 @default.
• W2027834534 hasConceptScore W2027834534C2775960820 @default.
• W2027834534 hasConceptScore W2027834534C2778111144 @default.
• W2027834534 hasConceptScore W2027834534C2778288131 @default.
• W2027834534 hasConceptScore W2027834534C2779306644 @default.
• W2027834534 hasConceptScore W2027834534C2780104272 @default.
• W2027834534 hasConceptScore W2027834534C2780689927 @default.
• W2027834534 hasConceptScore W2027834534C2984496839 @default.
• W2027834534 hasConceptScore W2027834534C55493867 @default.
• W2027834534 hasConceptScore W2027834534C71315377 @default.
• W2027834534 hasConceptScore W2027834534C71924100 @default.
• W2027834534 hasConceptScore W2027834534C86803240 @default.
• W2027834534 hasLocation W20278345341 @default.
• W2027834534 hasLocation W20278345342 @default.
• W2027834534 hasOpenAccess W2027834534 @default.
• W2027834534 hasPrimaryLocation W20278345341 @default.
• W2027834534 hasRelatedWork W1984571782 @default.
• W2027834534 hasRelatedWork W2003738309 @default.
• W2027834534 hasRelatedWork W2012394330 @default.
• W2027834534 hasRelatedWork W2014956999 @default.
• W2027834534 hasRelatedWork W2027834534 @default.
• W2027834534 hasRelatedWork W2080815888 @default.
• W2027834534 hasRelatedWork W2087751406 @default.
• W2027834534 hasRelatedWork W2156844778 @default.
• W2027834534 hasRelatedWork W2370888491 @default.
• W2027834534 hasRelatedWork W2411461027 @default.
• W2027834534 isParatext "false" @default.
• W2027834534 isRetracted "false" @default.
• W2027834534 magId "2027834534" @default.
• W2027834534 workType "article" @default.