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- W2027864771 endingPage "4432" @default.
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- W2027864771 abstract "Abstract Protein phosphorylation is the most important type of reversible post‐translational modification involved in the regulation of cellular signal‐transduction processes. In addition to controlling normal cellular physiology on the molecular level, perturbations of phosphorylation‐based signaling networks and cascades have been implicated in the onset and progression of various human diseases. Recent advances in mass spectrometry‐based proteomics helped to overcome many of the previous limitations in protein phosphorylation analysis. Improved isotope labeling and phosphopeptide enrichment strategies in conjunction with more powerful mass spectrometers and advances in data analysis have been integrated in highly efficient phosphoproteomics workflows, which are capable of monitoring up to several thousands of site‐specific phosphorylation events within one large‐scale analysis. Combined with ongoing efforts to define kinase‐substrate relationships in intact cells, these major achievements have considerable potential to assess phosphorylation‐based signaling networks on a system‐wide scale. Here, we provide an overview of these exciting developments and their potential to transform signal‐transduction research into a technology‐driven, high‐throughput science." @default.
- W2027864771 created "2016-06-24" @default.
- W2027864771 creator A5047949872 @default.
- W2027864771 creator A5048562857 @default.
- W2027864771 creator A5053972254 @default.
- W2027864771 creator A5054876740 @default.
- W2027864771 creator A5068086960 @default.
- W2027864771 date "2008-10-28" @default.
- W2027864771 modified "2023-09-25" @default.
- W2027864771 title "Quantitative phosphoproteomics - an emerging key technology in signal-transduction research" @default.
- W2027864771 cites W1484096248 @default.
- W2027864771 cites W1520738779 @default.
- W2027864771 cites W1639582946 @default.
- W2027864771 cites W1647597862 @default.
- W2027864771 cites W1965155369 @default.
- W2027864771 cites W1965807926 @default.
- W2027864771 cites W1968214151 @default.
- W2027864771 cites W1970213655 @default.
- W2027864771 cites W1970843851 @default.
- W2027864771 cites W1974024530 @default.
- W2027864771 cites W1974973994 @default.
- W2027864771 cites W1975414887 @default.
- W2027864771 cites W1975558168 @default.
- W2027864771 cites W1978254752 @default.
- W2027864771 cites W1982717121 @default.
- W2027864771 cites W1983836332 @default.
- W2027864771 cites W1984871500 @default.
- W2027864771 cites W1985625499 @default.
- W2027864771 cites W1985911638 @default.
- W2027864771 cites W1991989394 @default.
- W2027864771 cites W1992244448 @default.
- W2027864771 cites W1992848590 @default.
- W2027864771 cites W1993450321 @default.
- W2027864771 cites W1995454576 @default.
- W2027864771 cites W1995912930 @default.
- W2027864771 cites W1996063525 @default.
- W2027864771 cites W1996369227 @default.
- W2027864771 cites W1996693787 @default.
- W2027864771 cites W1996810566 @default.
- W2027864771 cites W1997634470 @default.
- W2027864771 cites W1999450178 @default.
- W2027864771 cites W1999811798 @default.
- W2027864771 cites W2000042427 @default.
- W2027864771 cites W2004331701 @default.
- W2027864771 cites W2004704197 @default.
- W2027864771 cites W2005126769 @default.
- W2027864771 cites W2009412756 @default.
- W2027864771 cites W2010161321 @default.
- W2027864771 cites W2010636476 @default.
- W2027864771 cites W2011147958 @default.
- W2027864771 cites W2012634952 @default.
- W2027864771 cites W2019858779 @default.
- W2027864771 cites W2021528276 @default.
- W2027864771 cites W2021682413 @default.
- W2027864771 cites W2023389323 @default.
- W2027864771 cites W2024923641 @default.
- W2027864771 cites W2026542427 @default.
- W2027864771 cites W2030205108 @default.
- W2027864771 cites W2030397967 @default.
- W2027864771 cites W2031955549 @default.
- W2027864771 cites W2033199777 @default.
- W2027864771 cites W2033889320 @default.
- W2027864771 cites W2034138130 @default.
- W2027864771 cites W2036264431 @default.
- W2027864771 cites W2037512713 @default.
- W2027864771 cites W2038163496 @default.
- W2027864771 cites W2039155298 @default.
- W2027864771 cites W2042044881 @default.
- W2027864771 cites W2042412160 @default.
- W2027864771 cites W2043794217 @default.
- W2027864771 cites W2046515690 @default.
- W2027864771 cites W2046602608 @default.
- W2027864771 cites W2048527293 @default.
- W2027864771 cites W2048666997 @default.
- W2027864771 cites W2052141890 @default.
- W2027864771 cites W2055152749 @default.
- W2027864771 cites W2055396579 @default.
- W2027864771 cites W2056655737 @default.
- W2027864771 cites W2060369427 @default.
- W2027864771 cites W2062049401 @default.
- W2027864771 cites W2065237499 @default.
- W2027864771 cites W2068481474 @default.
- W2027864771 cites W2069743555 @default.
- W2027864771 cites W2070391349 @default.
- W2027864771 cites W2071555141 @default.
- W2027864771 cites W2073179024 @default.
- W2027864771 cites W2074173825 @default.
- W2027864771 cites W2076718655 @default.
- W2027864771 cites W2078598194 @default.
- W2027864771 cites W2083731894 @default.
- W2027864771 cites W2085037886 @default.
- W2027864771 cites W2090079322 @default.
- W2027864771 cites W2090715627 @default.
- W2027864771 cites W2090806203 @default.
- W2027864771 cites W2091787667 @default.
- W2027864771 cites W2092817365 @default.
- W2027864771 cites W2093509030 @default.
- W2027864771 cites W2093913323 @default.