Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027881211> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2027881211 endingPage "1869" @default.
- W2027881211 startingPage "1860" @default.
- W2027881211 abstract "Not every postmenopausal woman with a low level of estrogen suffers from osteoporosis, and no correlation of bone density with serum estrogen level, but a significant correlation with adrenal androgens is often noted. Vitamin D3 has been reported to be osteoclastic in vitro, whereas the effectiveness of vitamin D3 for the treatment of osteoporosis is clinically relevant. To study the roles of these factors in the development of osteoporosis, we characterized aromatase activity converting androgens to estrogens in human osteoblasts, because postmenopausal women maintain considerable levels of adrenal androgens. Glucocorticoids at 10(-9)-10(-7) M transiently induced the expression and enzymatic activity of aromatase cytochrome P450 (P450AROM) in primary cultured osteoblasts, and the Km value for androstenedione (4.7 +/- 2.9 nM) was lower than that in adipose tissue and skin. Human osteoblasts showed a promoter specificity different from that found in other tissues. 1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3] alone did not induce aromatase activity, but enhanced and maintained glucocorticoid-induced P450AROM gene expression. This synergistic effect was not observed by other sex steroids or retinoic acids. The enhancement of P450AROM activity by 1,25-(OH)2D3 varied from 0.94-fold (no enhancement) to 2.40-fold (maximal enhancement) among the individual human osteoblasts examined, but the magnitude of the enhancement was significantly correlated with the level of vitamin D receptor messenger RNA (P < 0.05). Cycloheximide did not abolish the synergistic effect of 1,25-(OH)2D3, suggesting that de novo protein synthesis is not required for the synergism with 1,25-(OH)2D3. These results suggest that bone tissue can synthesize estrogen from adrenal androgens by a unique aromatase activity depending on the level of vitamin D receptor expressed." @default.
- W2027881211 created "2016-06-24" @default.
- W2027881211 creator A5050447556 @default.
- W2027881211 creator A5056329462 @default.
- W2027881211 creator A5072944049 @default.
- W2027881211 creator A5082846066 @default.
- W2027881211 creator A5083352188 @default.
- W2027881211 date "1996-05-01" @default.
- W2027881211 modified "2023-10-14" @default.
- W2027881211 title "1,25-Dihydroxyvitamin D3 enhances the enzymatic activity and expression of the messenger ribonucleic acid for aromatase cytochrome P450 synergistically with dexamethasone depending on the vitamin D receptor level in cultured human osteoblasts." @default.
- W2027881211 cites W1984544785 @default.
- W2027881211 cites W1996758205 @default.
- W2027881211 cites W2005091530 @default.
- W2027881211 cites W2009180025 @default.
- W2027881211 cites W2010880221 @default.
- W2027881211 cites W2011467252 @default.
- W2027881211 cites W2063115908 @default.
- W2027881211 cites W2073740870 @default.
- W2027881211 cites W2092547974 @default.
- W2027881211 cites W2117263637 @default.
- W2027881211 cites W2155683206 @default.
- W2027881211 cites W2314110838 @default.
- W2027881211 doi "https://doi.org/10.1210/endo.137.5.8612525" @default.
- W2027881211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8612525" @default.
- W2027881211 hasPublicationYear "1996" @default.
- W2027881211 type Work @default.
- W2027881211 sameAs 2027881211 @default.
- W2027881211 citedByCount "62" @default.
- W2027881211 countsByYear W20278812112012 @default.
- W2027881211 countsByYear W20278812112013 @default.
- W2027881211 countsByYear W20278812112014 @default.
- W2027881211 countsByYear W20278812112015 @default.
- W2027881211 countsByYear W20278812112016 @default.
- W2027881211 countsByYear W20278812112017 @default.
- W2027881211 countsByYear W20278812112018 @default.
- W2027881211 countsByYear W20278812112019 @default.
- W2027881211 countsByYear W20278812112020 @default.
- W2027881211 countsByYear W20278812112021 @default.
- W2027881211 crossrefType "journal-article" @default.
- W2027881211 hasAuthorship W2027881211A5050447556 @default.
- W2027881211 hasAuthorship W2027881211A5056329462 @default.
- W2027881211 hasAuthorship W2027881211A5072944049 @default.
- W2027881211 hasAuthorship W2027881211A5082846066 @default.
- W2027881211 hasAuthorship W2027881211A5083352188 @default.
- W2027881211 hasBestOaLocation W20278812111 @default.
- W2027881211 hasConcept C121608353 @default.
- W2027881211 hasConcept C124490489 @default.
- W2027881211 hasConcept C126322002 @default.
- W2027881211 hasConcept C134018914 @default.
- W2027881211 hasConcept C179639408 @default.
- W2027881211 hasConcept C185592680 @default.
- W2027881211 hasConcept C2776166826 @default.
- W2027881211 hasConcept C2776940978 @default.
- W2027881211 hasConcept C2777164284 @default.
- W2027881211 hasConcept C526171541 @default.
- W2027881211 hasConcept C530470458 @default.
- W2027881211 hasConcept C62231903 @default.
- W2027881211 hasConcept C71924100 @default.
- W2027881211 hasConcept C86803240 @default.
- W2027881211 hasConceptScore W2027881211C121608353 @default.
- W2027881211 hasConceptScore W2027881211C124490489 @default.
- W2027881211 hasConceptScore W2027881211C126322002 @default.
- W2027881211 hasConceptScore W2027881211C134018914 @default.
- W2027881211 hasConceptScore W2027881211C179639408 @default.
- W2027881211 hasConceptScore W2027881211C185592680 @default.
- W2027881211 hasConceptScore W2027881211C2776166826 @default.
- W2027881211 hasConceptScore W2027881211C2776940978 @default.
- W2027881211 hasConceptScore W2027881211C2777164284 @default.
- W2027881211 hasConceptScore W2027881211C526171541 @default.
- W2027881211 hasConceptScore W2027881211C530470458 @default.
- W2027881211 hasConceptScore W2027881211C62231903 @default.
- W2027881211 hasConceptScore W2027881211C71924100 @default.
- W2027881211 hasConceptScore W2027881211C86803240 @default.
- W2027881211 hasIssue "5" @default.
- W2027881211 hasLocation W20278812111 @default.
- W2027881211 hasLocation W20278812112 @default.
- W2027881211 hasOpenAccess W2027881211 @default.
- W2027881211 hasPrimaryLocation W20278812111 @default.
- W2027881211 hasRelatedWork W2009015955 @default.
- W2027881211 hasRelatedWork W2037727994 @default.
- W2027881211 hasRelatedWork W2054700953 @default.
- W2027881211 hasRelatedWork W2057515305 @default.
- W2027881211 hasRelatedWork W2086243145 @default.
- W2027881211 hasRelatedWork W2110010322 @default.
- W2027881211 hasRelatedWork W2146007589 @default.
- W2027881211 hasRelatedWork W2151426978 @default.
- W2027881211 hasRelatedWork W2926335606 @default.
- W2027881211 hasRelatedWork W4232275671 @default.
- W2027881211 hasVolume "137" @default.
- W2027881211 isParatext "false" @default.
- W2027881211 isRetracted "false" @default.
- W2027881211 magId "2027881211" @default.
- W2027881211 workType "article" @default.