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- W2027899657 abstract "In this study, high intensity focused ultrasound (HIFU) and PPAA (poly-propyl-acrylic acid) were combined at sublethal doses to achieve hemolysis of human erythrocytes. In a series of experiments, a suspension of erythrocytes (1A passive cavitation detection system) was utilized to monitor the acoustic emissions from the cell suspension during exposure to ultrasound. In the presence of PPAA, there is a significant increase in cavitation and hemolysis during ultrasound exposure at a pH of 6.1, but not at a pH of 7.4. PPAA is a pH-sensitive polymer, changing its conformation and its activity as the solution becomes more acidic, achieving its optimal active state at a pH of 6.1. The acoustic data and the activity of PPAA suggest that the polymer, in its active state, provides nucleation sites to the cell suspension and that cell/bubble interaction is the primary mechanism for cell damage." @default.
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- W2027899657 date "1999-02-01" @default.
- W2027899657 modified "2023-09-24" @default.
- W2027899657 title "Effect of tone burst ultrasound in combination with PPAA (poly‐propyl acrylic acid) on hemolysis of erythrocytes" @default.
- W2027899657 doi "https://doi.org/10.1121/1.425223" @default.
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